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Items: 1 to 20 of 171

1.

Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3.

Chen CM, Weng YT, Chen WL, Lin TH, Chao CY, Lin CH, Chen IC, Lee LC, Lin HY, Wu YR, Chen YC, Chang KH, Tang HY, Cheng ML, Lee-Chen GJ, Lin JY.

Free Radic Biol Med. 2014 Jun;71:339-50. doi: 10.1016/j.freeradbiomed.2014.03.023. Epub 2014 Mar 25.

PMID:
24675225
2.

Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3.

Chang KH, Chen WL, Wu YR, Lin TH, Wu YC, Chao CY, Lin JY, Lee LC, Chen YC, Lee-Chen GJ, Chen CM.

Neuropharmacology. 2014 Jun;81:166-75. doi: 10.1016/j.neuropharm.2014.01.032. Epub 2014 Jan 31.

PMID:
24486383
3.

Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells: therapeutic relevance to neurodegenerative disease.

Kim SS, Lim J, Bang Y, Gal J, Lee SU, Cho YC, Yoon G, Kang BY, Cheon SH, Choi HJ.

J Nutr Biochem. 2012 Oct;23(10):1314-23. doi: 10.1016/j.jnutbio.2011.07.012. Epub 2012 Jan 5.

PMID:
22227268
4.

FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3.

Araujo J, Breuer P, Dieringer S, Krauss S, Dorn S, Zimmermann K, Pfeifer A, Klockgether T, Wuellner U, Evert BO.

Hum Mol Genet. 2011 Aug 1;20(15):2928-41. doi: 10.1093/hmg/ddr197. Epub 2011 May 2.

PMID:
21536589
5.
6.

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer's disease.

Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM.

Drug Des Devel Ther. 2016 Feb 29;10:885-96. doi: 10.2147/DDDT.S96454. eCollection 2016.

7.

p53 orchestrates the PGC-1α-mediated antioxidant response upon mild redox and metabolic imbalance.

Aquilano K, Baldelli S, Pagliei B, Cannata SM, Rotilio G, Ciriolo MR.

Antioxid Redox Signal. 2013 Feb 1;18(4):386-99. doi: 10.1089/ars.2012.4615. Epub 2012 Sep 20.

8.

Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo.

Kühnl J, Roggenkamp D, Gehrke SA, Stäb F, Wenck H, Kolbe L, Neufang G.

Exp Dermatol. 2015 Jan;24(1):42-7. doi: 10.1111/exd.12588. Epub 2014 Dec 8.

PMID:
25381913
9.

Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice.

Lin Y, Kuang Y, Li K, Wang S, Ji S, Chen K, Song W, Qiao X, Ye M.

Bioorg Med Chem. 2017 Oct 15;25(20):5522-5530. doi: 10.1016/j.bmc.2017.08.018. Epub 2017 Aug 15.

PMID:
28835349
10.
11.

Dehydroglyasperin C isolated from licorice caused Nrf2-mediated induction of detoxifying enzymes.

Seo JY, Lee YS, Kim HJ, Lim SS, Lim JS, Lee IA, Lee CH, Yoon Park JH, Kim JS.

J Agric Food Chem. 2010 Feb 10;58(3):1603-8. doi: 10.1021/jf9036062.

PMID:
20088509
12.

Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3.

Chang KH, Chen WL, Lee LC, Lin CH, Kung PJ, Lin TH, Wu YC, Wu YR, Chen YC, Lee-Chen GJ, Chen CM.

Evid Based Complement Alternat Med. 2013;2013:471659. doi: 10.1155/2013/471659. Epub 2013 Feb 25.

13.

Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis).

Izumi Y, Matsumura A, Wakita S, Akagi K, Fukuda H, Kume T, Irie K, Takada-Takatori Y, Sugimoto H, Hashimoto T, Akaike A.

Free Radic Biol Med. 2012 Aug 15;53(4):669-79. doi: 10.1016/j.freeradbiomed.2012.06.021. Epub 2012 Jun 27.

PMID:
22749808
14.

Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.

Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen SN, Nikolić D, Pauli GF, van Breemen RB, Dietz BM, Bolton JL.

Chem Res Toxicol. 2015 Nov 16;28(11):2130-41. doi: 10.1021/acs.chemrestox.5b00310. Epub 2015 Nov 5.

15.

The potential of indole and a synthetic derivative for polyQ aggregation reduction by enhancement of the chaperone and autophagy systems.

Lin CH, Wu YR, Kung PJ, Chen WL, Lee LC, Lin TH, Chao CY, Chen CM, Chang KH, Janreddy D, Lee-Chen GJ, Yao CF.

ACS Chem Neurosci. 2014 Oct 15;5(10):1063-74. doi: 10.1021/cn500075u. Epub 2014 Sep 19.

PMID:
25197952
16.

Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway.

Furusawa J, Funakoshi-Tago M, Mashino T, Tago K, Inoue H, Sonoda Y, Kasahara T.

Int Immunopharmacol. 2009 Apr;9(4):499-507.

PMID:
19291859
17.

Antispasmodic activity of licochalcone A, a species-specific ingredient of Glycyrrhiza inflata roots.

Nagai H, He JX, Tani T, Akao T.

J Pharm Pharmacol. 2007 Oct;59(10):1421-6.

PMID:
17910818
18.

Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease.

Yu YC, Kuo CL, Cheng WL, Liu CS, Hsieh M.

J Neurosci Res. 2009 Jun;87(8):1884-91. doi: 10.1002/jnr.22011.

PMID:
19185026
19.

Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.

Dunlap TL, Wang S, Simmler C, Chen SN, Pauli GF, Dietz BM, Bolton JL.

Chem Res Toxicol. 2015 Aug 17;28(8):1584-94. doi: 10.1021/acs.chemrestox.5b00157. Epub 2015 Jul 16.

20.

Estrogen Signals Through Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease.

Besse-Patin A, Léveillé M, Oropeza D, Nguyen BN, Prat A, Estall JL.

Gastroenterology. 2017 Jan;152(1):243-256. doi: 10.1053/j.gastro.2016.09.017. Epub 2016 Sep 20.

PMID:
27658772

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