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The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency.

Nemec AA, Murphy DL, Donigan KA, Sweasy JB.

J Biol Chem. 2014 May 16;289(20):13708-16. doi: 10.1074/jbc.M114.550400.


Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.

Nemec AA, Donigan KA, Murphy DL, Jaeger J, Sweasy JB.

J Biol Chem. 2012 Jul 6;287(28):23840-9. doi: 10.1074/jbc.M112.362111.


DNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation.

Donigan KA, Tuck D, Schulz V, Sweasy JB.

Mutagenesis. 2012 Nov;27(6):683-91. doi: 10.1093/mutage/ges034.


A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation.

Yamtich J, Nemec AA, Keh A, Sweasy JB.

PLoS Genet. 2012;8(11):e1003052. doi: 10.1371/journal.pgen.1003052.


The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator.

Murphy DL, Donigan KA, Jaeger J, Sweasy JB.

Biochemistry. 2012 Jul 3;51(26):5269-75.


Efficiency and fidelity of human DNA polymerases λ and β during gap-filling DNA synthesis.

Brown JA, Pack LR, Sanman LE, Suo Z.

DNA Repair (Amst). 2011 Jan 2;10(1):24-33. doi: 10.1016/j.dnarep.2010.09.005.


The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation.

Donigan KA, Hile SE, Eckert KA, Sweasy JB.

DNA Repair (Amst). 2012 Apr 1;11(4):381-90. doi: 10.1016/j.dnarep.2012.01.004.


Induction of DNA polymerase beta-dependent base excision repair in response to oxidative stress in vivo.

Cabelof DC, Raffoul JJ, Yanamadala S, Guo Z, Heydari AR.

Carcinogenesis. 2002 Sep;23(9):1419-25.


Mammalian DNA beta-polymerase in base excision repair of alkylation damage.

Sobol RW, Wilson SH.

Prog Nucleic Acid Res Mol Biol. 2001;68:57-74. Review.


Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates.

Senejani AG, Dalal S, Liu Y, Nottoli TP, McGrath JM, Clairmont CS, Sweasy JB.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6632-7. doi: 10.1073/pnas.1200800109.


Cellular roles of DNA polymerase beta.

Ray S, Menezes MR, Senejani A, Sweasy JB.

Yale J Biol Med. 2013 Dec 13;86(4):463-9. Review.


Bypass of a 5',8-cyclopurine-2'-deoxynucleoside by DNA polymerase β during DNA replication and base excision repair leads to nucleotide misinsertions and DNA strand breaks.

Jiang Z, Xu M, Lai Y, Laverde EE, Terzidis MA, Masi A, Chatgilialoglu C, Liu Y.

DNA Repair (Amst). 2015 Sep;33:24-34. doi: 10.1016/j.dnarep.2015.06.004.


The K167I variant of DNA polymerase β that is found in Esophageal Carcinoma patients impairs polymerase activity and BER.

Wang Y, Zang W, Du Y, Chen X, Zhao G.

Sci Rep. 2015 Nov 3;5:15986. doi: 10.1038/srep15986.


A novel inhibitor of DNA polymerase beta enhances the ability of temozolomide to impair the growth of colon cancer cells.

Jaiswal AS, Banerjee S, Panda H, Bulkin CD, Izumi T, Sarkar FH, Ostrov DA, Narayan S.

Mol Cancer Res. 2009 Dec;7(12):1973-83. doi: 10.1158/1541-7786.MCR-09-0309.


FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair.

Prasad R, Dianov GL, Bohr VA, Wilson SH.

J Biol Chem. 2000 Feb 11;275(6):4460-6.


Human POLB gene is mutated in high percentage of colorectal tumors.

Donigan KA, Sun KW, Nemec AA, Murphy DL, Cong X, Northrup V, Zelterman D, Sweasy JB.

J Biol Chem. 2012 Jul 6;287(28):23830-9. doi: 10.1074/jbc.M111.324947.


Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses.

Sobol RW, Kartalou M, Almeida KH, Joyce DF, Engelward BP, Horton JK, Prasad R, Samson LD, Wilson SH.

J Biol Chem. 2003 Oct 10;278(41):39951-9.


Role of DNA polymerase beta in the excision step of long patch mammalian base excision repair.

Dianov GL, Prasad R, Wilson SH, Bohr VA.

J Biol Chem. 1999 May 14;274(20):13741-3.


The E295K cancer variant of human polymerase β favors the mismatch conformational pathway during nucleotide selection.

Eckenroth BE, Towle-Weicksel JB, Sweasy JB, Doublié S.

J Biol Chem. 2013 Nov 29;288(48):34850-60. doi: 10.1074/jbc.M113.510891.

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