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Items: 1 to 20 of 199


OVA66 increases cell growth, invasion and survival via regulation of IGF-1R-MAPK signaling in human cancer cells.

Rao W, Li H, Song F, Zhang R, Yin Q, Wang Y, Xi Y, Ge H.

Carcinogenesis. 2014 Jul;35(7):1573-81. doi: 10.1093/carcin/bgu070. Epub 2014 Mar 25.


IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma.

Gao L, Wang X, Wang X, Zhang L, Qiang C, Chang S, Ren W, Li S, Yang Y, Tong D, Chen C, Li Z, Song T, Zhi K, Huang C.

Oncotarget. 2014 May 15;5(9):2562-74.


P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin.

Cheung LW, Mak AS, Cheung AN, Ngan HY, Leung PC, Wong AS.

Oncogene. 2011 Jun 30;30(26):2964-74. doi: 10.1038/onc.2011.7. Epub 2011 Feb 14.


Anticancer effect of genistein on BG-1 ovarian cancer growth induced by 17 β-estradiol or bisphenol A via the suppression of the crosstalk between estrogen receptor α and insulin-like growth factor-1 receptor signaling pathways.

Hwang KA, Park MA, Kang NH, Yi BR, Hyun SH, Jeung EB, Choi KC.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):637-46. doi: 10.1016/j.taap.2013.07.027. Epub 2013 Aug 8.


Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells.

Fang J, Zhou Q, Shi XL, Jiang BH.

Carcinogenesis. 2007 Mar;28(3):713-23. Epub 2006 Oct 25.


A Blockade of IGF Signaling Sensitizes Human Ovarian Cancer Cells to the Anthelmintic Niclosamide-Induced Anti-Proliferative and Anticancer Activities.

Deng Y, Wang Z, Zhang F, Qiao M, Yan Z, Wei Q, Wang J, Liu H, Fan J, Zou Y, Liao J, Hu X, Chen L, Yu X, Haydon RC, Luu HH, Qi H, He TC, Zhang J.

Cell Physiol Biochem. 2016;39(3):871-88. doi: 10.1159/000447797. Epub 2016 Aug 9.


Inhibitory effect of small interfering RNA targeting insulin-like growth factor-I receptor in ovarian cancer OVCAR3 cells.

An Y, Cai Y, Guan Y, Cai L, Yang Y, Feng X, Zheng J.

Cancer Biother Radiopharm. 2010 Oct;25(5):545-52. doi: 10.1089/cbr.2009.0712.


A novel small molecule inhibitor of FAK and IGF-1R protein interactions decreases growth of human esophageal carcinoma.

Ucar DA, Cox A, He DH, Ostrov DA, Kurenova E, Hochwald SN.

Anticancer Agents Med Chem. 2011 Sep;11(7):629-37.


Metformin inhibits the proliferation of human prostate cancer PC-3 cells via the downregulation of insulin-like growth factor 1 receptor.

Kato H, Sekine Y, Furuya Y, Miyazawa Y, Koike H, Suzuki K.

Biochem Biophys Res Commun. 2015 May 22;461(1):115-21. doi: 10.1016/j.bbrc.2015.03.178. Epub 2015 Apr 7.


Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors.

Kim WY, Prudkin L, Feng L, Kim ES, Hennessy B, Lee JS, Lee JJ, Glisson B, Lippman SM, Wistuba II, Hong WK, Lee HY.

Cancer. 2012 Aug 15;118(16):3993-4003. doi: 10.1002/cncr.26656. Epub 2012 Feb 22. Erratum in: Cancer. 2012 Dec 15;118(24):6301.


Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysin.

Adachi Y, Li R, Yamamoto H, Min Y, Piao W, Wang Y, Imsumran A, Li H, Arimura Y, Lee CT, Imai K, Carbone DP, Shinomura Y.

Carcinogenesis. 2009 Aug;30(8):1305-13. doi: 10.1093/carcin/bgp134. Epub 2009 Jun 3.


MicroRNA-320a suppresses in GBM patients and modulates glioma cell functions by targeting IGF-1R.

Guo T, Feng Y, Liu Q, Yang X, Jiang T, Chen Y, Zhang Q.

Tumour Biol. 2014 Nov;35(11):11269-75. doi: 10.1007/s13277-014-2283-4. Epub 2014 Aug 13.


Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and Bax activation.

Wilsbacher JL, Zhang Q, Tucker LA, Hubbard RD, Sheppard GS, Bamaung NY, Fidanze SD, Wang GT, Hu X, Davidsen SK, Bell RL, Wang J.

J Biol Chem. 2008 Aug 29;283(35):23721-30. doi: 10.1074/jbc.M708360200. Epub 2008 Jun 17.


The inhibitory effects of NKX3.1 on IGF-1R expression and its signalling pathway in human prostatic carcinoma PC3 cells.

Zhang PJ, Hu XY, Liu CY, Chen ZB, Ni NN, Yu Y, Yang LN, Huang ZQ, Liu QW, Jiang AL.

Asian J Androl. 2012 May;14(3):493-8. doi: 10.1038/aja.2011.158. Epub 2011 Dec 19.


Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes.

Zhang Y, Moerkens M, Ramaiahgari S, de Bont H, Price L, Meerman J, van de Water B.

Breast Cancer Res. 2011 May 19;13(3):R52. doi: 10.1186/bcr2883.


Picropodophyllin inhibits tumor growth of human nasopharyngeal carcinoma in a mouse model.

Yin SC, Guo W, Tao ZZ.

Biochem Biophys Res Commun. 2013 Sep 13;439(1):1-5. doi: 10.1016/j.bbrc.2013.08.050. Epub 2013 Aug 22.


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