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Items: 1 to 20 of 90

1.

Leptin-promoted cilia assembly is critical for normal energy balance.

Han YM, Kang GM, Byun K, Ko HW, Kim J, Shin MS, Kim HK, Gil SY, Yu JH, Lee B, Kim MS.

J Clin Invest. 2014 May;124(5):2193-7. doi: 10.1172/JCI69395. Epub 2014 Mar 25.

2.

Leptin Elongates Hypothalamic Neuronal Cilia via Transcriptional Regulation and Actin Destabilization.

Kang GM, Han YM, Ko HW, Kim J, Oh BC, Kwon I, Kim MS.

J Biol Chem. 2015 Jul 17;290(29):18146-55. doi: 10.1074/jbc.M115.639468. Epub 2015 Jun 3.

3.

Hypothalamic glycogen synthase kinase 3β has a central role in the regulation of food intake and glucose metabolism.

Benzler J, Ganjam GK, Krüger M, Pinkenburg O, Kutschke M, Stöhr S, Steger J, Koch CE, Ölkrug R, Schwartz MW, Shepherd PR, Grattan DR, Tups A.

Biochem J. 2012 Oct 1;447(1):175-84. doi: 10.1042/BJ20120834.

4.

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.

Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ.

J Clin Invest. 2007 Aug;117(8):2325-36.

5.

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC.

J Clin Invest. 2006 Jul;116(7):1886-901. Epub 2006 Jun 22.

6.

Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice.

Berglund ED, Vianna CR, Donato J Jr, Kim MH, Chuang JC, Lee CE, Lauzon DA, Lin P, Brule LJ, Scott MM, Coppari R, Elmquist JK.

J Clin Invest. 2012 Mar;122(3):1000-9. doi: 10.1172/JCI59816. Epub 2012 Feb 13.

7.

Central glucagon-like peptide 1 receptor-induced anorexia requires glucose metabolism-mediated suppression of AMPK and is impaired by central fructose.

Burmeister MA, Ayala J, Drucker DJ, Ayala JE.

Am J Physiol Endocrinol Metab. 2013 Apr 1;304(7):E677-85. doi: 10.1152/ajpendo.00446.2012. Epub 2013 Jan 22.

8.

Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.

Ren D, Zhou Y, Morris D, Li M, Li Z, Rui L.

J Clin Invest. 2007 Feb;117(2):397-406. Epub 2007 Jan 18.

9.

Primary cilia in energy balance signaling and metabolic disorder.

Lee H, Song J, Jung JH, Ko HW.

BMB Rep. 2015 Dec;48(12):647-54. Review.

10.

Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response.

Quan W, Kim HK, Moon EY, Kim SS, Choi CS, Komatsu M, Jeong YT, Lee MK, Kim KW, Kim MS, Lee MS.

Endocrinology. 2012 Apr;153(4):1817-26. doi: 10.1210/en.2011-1882. Epub 2012 Feb 14.

PMID:
22334718
11.

Hypothalamic carnitine metabolism integrates nutrient and hormonal feedback to regulate energy homeostasis.

Stark R, Reichenbach A, Andrews ZB.

Mol Cell Endocrinol. 2015 Dec 15;418 Pt 1:9-16. doi: 10.1016/j.mce.2015.08.002. Epub 2015 Aug 8. Review.

PMID:
26261054
12.

Nutrient-sensing hypothalamic TXNIP links nutrient excess to energy imbalance in mice.

Blouet C, Schwartz GJ.

J Neurosci. 2011 Apr 20;31(16):6019-27. doi: 10.1523/JNEUROSCI.6498-10.2011.

13.

IKKε is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity.

Weissmann L, Quaresma PG, Santos AC, de Matos AH, Pascoal VD, Zanotto TM, Castro G, Guadagnini D, da Silva JM, Velloso LA, Bittencourt JC, Lopes-Cendes I, Saad MJ, Prada PO.

Diabetes. 2014 Oct;63(10):3334-45. doi: 10.2337/db13-1817. Epub 2014 May 8.

14.

Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight.

Kim HK, Youn BS, Shin MS, Namkoong C, Park KH, Baik JH, Kim JB, Park JY, Lee KU, Kim YB, Kim MS.

Diabetes. 2010 Nov;59(11):2772-80. doi: 10.2337/db10-0145. Epub 2010 Aug 26.

15.

Leptin signalling pathways in hypothalamic neurons.

Kwon O, Kim KW, Kim MS.

Cell Mol Life Sci. 2016 Apr;73(7):1457-77. doi: 10.1007/s00018-016-2133-1. Epub 2016 Jan 19. Review.

PMID:
26786898
16.

Neuropeptide W: an anorectic peptide regulated by leptin and metabolic state.

Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F, Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S, Cone RD, Nakazato M.

Endocrinology. 2010 May;151(5):2200-10. doi: 10.1210/en.2009-1153. Epub 2010 Feb 26.

PMID:
20189998
17.

NF-kappaB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia.

Jang PG, Namkoong C, Kang GM, Hur MW, Kim SW, Kim GH, Kang Y, Jeon MJ, Kim EH, Lee MS, Karin M, Baik JH, Park JY, Lee KU, Kim YB, Kim MS.

J Biol Chem. 2010 Mar 26;285(13):9706-15. doi: 10.1074/jbc.M109.070706. Epub 2010 Jan 22.

18.

Modulation of primary cilia length by melanin-concentrating hormone receptor 1.

Hamamoto A, Yamato S, Katoh Y, Nakayama K, Yoshimura K, Takeda S, Kobayashi Y, Saito Y.

Cell Signal. 2016 Jun;28(6):572-84. doi: 10.1016/j.cellsig.2016.02.018. Epub 2016 Mar 2.

PMID:
26946173
19.

Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance.

Sahu A.

Front Neuroendocrinol. 2003 Dec;24(4):225-53. Review.

PMID:
14726256
20.

Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses.

Thaler JP, Choi SJ, Sajan MP, Ogimoto K, Nguyen HT, Matsen M, Benoit SC, Wisse BE, Farese RV, Schwartz MW.

Endocrinology. 2009 Dec;150(12):5362-72. doi: 10.1210/en.2009-0509. Epub 2009 Oct 9.

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