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Local translation of TC10 is required for membrane expansion during axon outgrowth.

Gracias NG, Shirkey-Son NJ, Hengst U.

Nat Commun. 2014 Mar 25;5:3506. doi: 10.1038/ncomms4506.


Axonal elongation triggered by stimulus-induced local translation of a polarity complex protein.

Hengst U, Deglincerti A, Kim HJ, Jeon NL, Jaffrey SR.

Nat Cell Biol. 2009 Aug;11(8):1024-30. doi: 10.1038/ncb1916. Epub 2009 Jul 20.


The TC10-Exo70 complex is essential for membrane expansion and axonal specification in developing neurons.

Dupraz S, Grassi D, Bernis ME, Sosa L, Bisbal M, Gastaldi L, Jausoro I, Cáceres A, Pfenninger KH, Quiroga S.

J Neurosci. 2009 Oct 21;29(42):13292-301. doi: 10.1523/JNEUROSCI.3907-09.2009.


Rheb and mTOR regulate neuronal polarity through Rap1B.

Li YH, Werner H, Püschel AW.

J Biol Chem. 2008 Nov 28;283(48):33784-92. doi: 10.1074/jbc.M802431200. Epub 2008 Oct 8.


GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70.

Fujita A, Koinuma S, Yasuda S, Nagai H, Kamiguchi H, Wada N, Nakamura T.

PLoS One. 2013 Nov 4;8(11):e79689. doi: 10.1371/journal.pone.0079689. eCollection 2013.


Axon growth-stimulus package includes local translation.

Macara IG, Iioka H, Mili S.

Nat Cell Biol. 2009 Aug;11(8):919-21. doi: 10.1038/ncb0809-919.


An NGF-induced Exo70-TC10 complex locally antagonises Cdc42-mediated activation of N-WASP to modulate neurite outgrowth.

Pommereit D, Wouters FS.

J Cell Sci. 2007 Aug 1;120(Pt 15):2694-705. Epub 2007 Jul 17.


Nerve growth factor-induced formation of axonal filopodia and collateral branches involves the intra-axonal synthesis of regulators of the actin-nucleating Arp2/3 complex.

Spillane M, Ketschek A, Donnelly CJ, Pacheco A, Twiss JL, Gallo G.

J Neurosci. 2012 Dec 5;32(49):17671-89. doi: 10.1523/JNEUROSCI.1079-12.2012.


Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons.

Willis D, Li KW, Zheng JQ, Chang JH, Smit AB, Kelly T, Merianda TT, Sylvester J, van Minnen J, Twiss JL.

J Neurosci. 2005 Jan 26;25(4):778-91. Erratum in: J Neurosci. 2010 Nov 10;30(45):np. Smit, August [corrected to Smit, August B].


Pea3 transcription factor family members Etv4 and Etv5 mediate retrograde signaling and axonal growth of DRG sensory neurons in response to NGF.

Fontanet P, Irala D, Alsina FC, Paratcha G, Ledda F.

J Neurosci. 2013 Oct 2;33(40):15940-51. doi: 10.1523/JNEUROSCI.0928-13.2013.


The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord.

Codeluppi S, Svensson CI, Hefferan MP, Valencia F, Silldorff MD, Oshiro M, Marsala M, Pasquale EB.

J Neurosci. 2009 Jan 28;29(4):1093-104. doi: 10.1523/JNEUROSCI.4103-08.2009.


Tsc2-Rheb signaling regulates EphA-mediated axon guidance.

Nie D, Di Nardo A, Han JM, Baharanyi H, Kramvis I, Huynh T, Dabora S, Codeluppi S, Pandolfi PP, Pasquale EB, Sahin M.

Nat Neurosci. 2010 Feb;13(2):163-72. doi: 10.1038/nn.2477. Epub 2010 Jan 10.


Signaling mediated by the closely related mammalian Rho family GTPases TC10 and Cdc42 suggests distinct functional pathways.

Murphy GA, Jillian SA, Michaelson D, Philips MR, D'Eustachio P, Rush MG.

Cell Growth Differ. 2001 Mar;12(3):157-67.


Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration.

Cho Y, Di Liberto V, Carlin D, Abe N, Li KH, Burlingame AL, Guan S, Michaelevski I, Cavalli V.

J Biol Chem. 2014 May 30;289(22):15820-32. doi: 10.1074/jbc.M113.536607. Epub 2014 Apr 15.


Artemin activates axonal growth via SFK and ERK-dependent signalling pathways in mature dorsal root ganglia neurons.

Jeong DG, Park WK, Park S.

Cell Biochem Funct. 2008 Mar-Apr;26(2):210-20.


Rheb, an activator of target of rapamycin, in the blackback land crab, Gecarcinus lateralis: cloning and effects of molting and unweighting on expression in skeletal muscle.

MacLea KS, Abuhagr AM, Pitts NL, Covi JA, Bader BD, Chang ES, Mykles DL.

J Exp Biol. 2012 Feb 15;215(Pt 4):590-604. doi: 10.1242/jeb.062869.


Effects of proinflammatory cytokines on axonal outgrowth from adult rat lumbar dorsal root ganglia using a novel three-dimensional culture system.

Kim H, W Caspar T, Shah SB, Hsieh AH.

Spine J. 2015 Aug 1;15(8):1823-31. doi: 10.1016/j.spinee.2015.03.017. Epub 2015 Mar 20.


PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10.

Neudauer CL, Joberty G, Macara IG.

Biochem Biophys Res Commun. 2001 Jan 19;280(2):541-7.


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