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Direct T cell activation via CD40 ligand generates high avidity CD8+ T cells capable of breaking immunological tolerance for the control of tumors.

Soong RS, Song L, Trieu J, Lee SY, He L, Tsai YC, Wu TC, Hung CF.

PLoS One. 2014 Mar 24;9(3):e93162. doi: 10.1371/journal.pone.0093162. eCollection 2014.


Xenogeneic human p53 DNA vaccination by electroporation breaks immune tolerance to control murine tumors expressing mouse p53.

Soong RS, Trieu J, Lee SY, He L, Tsai YC, Wu TC, Hung CF.

PLoS One. 2013;8(2):e56912. doi: 10.1371/journal.pone.0056912. Epub 2013 Feb 15.


A novel T cell-based vaccine capable of stimulating long-term functional CTL memory against B16 melanoma via CD40L signaling.

Xie Y, Wang L, Freywald A, Qureshi M, Chen Y, Xiang J.

Cell Mol Immunol. 2013 Jan;10(1):72-7. doi: 10.1038/cmi.2012.37. Epub 2012 Oct 8.


Nonreplicating recombinant vaccinia virus expressing CD40 ligand enhances APC capacity to stimulate specific CD4+ and CD8+ T cell responses.

Feder-Mengus C, Schultz-Thater E, Oertli D, Marti WR, Heberer M, Spagnoli GC, Zajac P.

Hum Gene Ther. 2005 Mar;16(3):348-60.


A multi-trimeric fusion of CD40L and gp100 tumor antigen activates dendritic cells and enhances survival in a B16-F10 melanoma DNA vaccine model.

Gupta S, Termini JM, Rivas Y, Otero M, Raffa FN, Bhat V, Farooq A, Stone GW.

Vaccine. 2015 Sep 11;33(38):4798-806. doi: 10.1016/j.vaccine.2015.07.081. Epub 2015 Aug 1.


CD40 ligand promotes priming of fully potent antitumor CD4(+) T cells in draining lymph nodes in the presence of apoptotic tumor cells.

Fujita N, Kagamu H, Yoshizawa H, Itoh K, Kuriyama H, Matsumoto N, Ishiguro T, Tanaka J, Suzuki E, Hamada H, Gejyo F.

J Immunol. 2001 Nov 15;167(10):5678-88.


Activation of tolerogenic dendritic cells in the tumor draining lymph nodes by CD8+ T cells engineered to express CD40 ligand.

Higham EM, Wittrup KD, Chen J.

J Immunol. 2010 Apr 1;184(7):3394-400. doi: 10.4049/jimmunol.0903111. Epub 2010 Mar 3.


Vaccination with a fusion protein that introduces HIV-1 gag antigen into a multitrimer CD40L construct results in enhanced CD8+ T cell responses and protection from viral challenge by vaccinia-gag.

Gupta S, Termini JM, Raffa FN, Williams CA, Kornbluth RS, Stone GW.

J Virol. 2014 Feb;88(3):1492-501. doi: 10.1128/JVI.02229-13. Epub 2013 Nov 13.


Enhanced protective immunity derived from dendritic cells with phagocytosis of CD40 ligand transgene-engineered apoptotic tumor cells via increased dendritic cell maturation.

Parameswaran S, Khalil M, Ahmed KA, Sharma RK, Xiang J.

Tumori. 2015 Nov-Dec;101(6):637-43. doi: 10.5301/tj.5000297. Epub 2015 May 15.


IL-12-mediated STAT4 signaling and TCR signal strength cooperate in the induction of CD40L in human and mouse CD8+ T cells.

Stark R, Hartung A, Zehn D, Frentsch M, Thiel A.

Eur J Immunol. 2013 Jun;43(6):1511-7. doi: 10.1002/eji.201243218.


Lentivector prime and vaccinia virus vector boost generate high-quality CD8 memory T cells and prevent autochthonous mouse melanoma.

Xiao H, Peng Y, Hong Y, Liu Y, Guo ZS, Bartlett DL, Fu N, He Y.

J Immunol. 2011 Aug 15;187(4):1788-96. doi: 10.4049/jimmunol.1101138. Epub 2011 Jul 11.


Antitumor responses induced by transgenic expression of CD40 ligand.

Grossmann ME, Brown MP, Brenner MK.

Hum Gene Ther. 1997 Nov 1;8(16):1935-43.


CD4+ Th-APC with acquired peptide/MHC class I and II complexes stimulate type 1 helper CD4+ and central memory CD8+ T cell responses.

Umeshappa CS, Huang H, Xie Y, Wei Y, Mulligan SJ, Deng Y, Xiang J.

J Immunol. 2009 Jan 1;182(1):193-206.


Molecular requirements for CD8-mediated rejection of a MUC1-expressing pancreatic carcinoma: implications for tumor vaccines.

Sivinski CL, Kohlgraf KG, VanLith ML, Morikane K, Tempero RM, Hollingsworth MA.

Cancer Immunol Immunother. 2002 Aug;51(6):327-40. Epub 2002 May 4.


Vaccine therapy of established tumors in the absence of autoimmunity.

Hodge JW, Grosenbach DW, Aarts WM, Poole DJ, Schlom J.

Clin Cancer Res. 2003 May;9(5):1837-49.


Synergistic CD40 signaling on APCs and CD8 T cells drives efficient CD8 response and memory differentiation.

Meunier S, Rapetti L, Beziaud L, Pontoux C, Legrand A, Tanchot C.

J Leukoc Biol. 2012 Jun;91(6):859-69. doi: 10.1189/jlb.0611292. Epub 2012 Jan 11.


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