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Small-molecule TrkB agonist 7,8-dihydroxyflavone reverses cognitive and synaptic plasticity deficits in a rat model of schizophrenia.

Yang YJ, Li YK, Wang W, Wan JG, Yu B, Wang MZ, Hu B.

Pharmacol Biochem Behav. 2014 Jul;122:30-6. doi: 10.1016/j.pbb.2014.03.013. Epub 2014 Mar 21.


Activation of TrkB by 7,8-dihydroxyflavone prevents fear memory defects and facilitates amygdalar synaptic plasticity in aging.

Zeng Y, Liu Y, Wu M, Liu J, Hu Q.

J Alzheimers Dis. 2012;31(4):765-78. doi: 10.3233/JAD-2012-120886.


7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats.

Zeng Y, Lv F, Li L, Yu H, Dong M, Fu Q.

J Neurochem. 2012 Aug;122(4):800-11. doi: 10.1111/j.1471-4159.2012.07830.x. Epub 2012 Jul 9.


7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease.

Devi L, Ohno M.

Neuropsychopharmacology. 2012 Jan;37(2):434-44. doi: 10.1038/npp.2011.191. Epub 2011 Sep 7.


Cognitive impairments following cranial irradiation can be mitigated by treatment with a tropomyosin receptor kinase B agonist.

Yang P, Leu D, Ye K, Srinivasan C, Fike JR, Huang TT.

Exp Neurol. 2016 May;279:178-186. doi: 10.1016/j.expneurol.2016.02.021. Epub 2016 Mar 2.


Flavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation.

Agrawal R, Noble E, Tyagi E, Zhuang Y, Ying Z, Gomez-Pinilla F.

Biochim Biophys Acta. 2015 May;1852(5):862-72. doi: 10.1016/j.bbadis.2015.01.018. Epub 2015 Feb 3.


TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease.

Gao L, Tian M, Zhao HY, Xu QQ, Huang YM, Si QC, Tian Q, Wu QM, Hu XM, Sun LB, McClintock SM, Zeng Y.

J Neurochem. 2016 Feb;136(3):620-36. doi: 10.1111/jnc.13432. Epub 2015 Dec 29.


7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice.

Bollen E, Vanmierlo T, Akkerman S, Wouters C, Steinbusch HM, Prickaerts J.

Behav Brain Res. 2013 Nov 15;257:8-12. doi: 10.1016/j.bbr.2013.09.029. Epub 2013 Sep 23.


7, 8-Dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities in a mouse model of fragile X syndrome.

Tian M, Zeng Y, Hu Y, Yuan X, Liu S, Li J, Lu P, Sun Y, Gao L, Fu D, Li Y, Wang S, McClintock SM.

Neuropharmacology. 2015 Feb;89:43-53. doi: 10.1016/j.neuropharm.2014.09.006. Epub 2014 Sep 16.


7,8-Dihydroxyflavone leads to survival of cultured embryonic motoneurons by activating intracellular signaling pathways.

Tsai T, Klausmeyer A, Conrad R, Gottschling C, Leo M, Faissner A, Wiese S.

Mol Cell Neurosci. 2013 Sep;56:18-28. doi: 10.1016/j.mcn.2013.02.007. Epub 2013 Mar 14.


Glutamate receptor 1 phosphorylation at serine 845 contributes to the therapeutic effect of olanzapine on schizophrenia-like cognitive impairments.

Zhang C, Fang Y, Xu L.

Schizophr Res. 2014 Nov;159(2-3):376-84. doi: 10.1016/j.schres.2014.07.054. Epub 2014 Sep 11.


7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss.

Castello NA, Nguyen MH, Tran JD, Cheng D, Green KN, LaFerla FM.

PLoS One. 2014 Mar 10;9(3):e91453. doi: 10.1371/journal.pone.0091453. eCollection 2014.


Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling.

Wu CH, Hung TH, Chen CC, Ke CH, Lee CY, Wang PY, Chen SF.

PLoS One. 2014 Nov 21;9(11):e113397. doi: 10.1371/journal.pone.0113397. eCollection 2014.


Propofol exposure during late stages of pregnancy impairs learning and memory in rat offspring via the BDNF-TrkB signalling pathway.

Zhong L, Luo F, Zhao W, Feng Y, Wu L, Lin J, Liu T, Wang S, You X, Zhang W.

J Cell Mol Med. 2016 Oct;20(10):1920-31. doi: 10.1111/jcmm.12884. Epub 2016 Jun 14.


Effects of TrkB agonist 7,8-dihydroxyflavone on sensory gating deficits in mice after administration of methamphetamine.

Ren Q, Zhang JC, Fujita Y, Ma M, Wu J, Hashimoto K.

Pharmacol Biochem Behav. 2013 May;106:124-7. doi: 10.1016/j.pbb.2013.03.016. Epub 2013 Apr 6.


The Small-Molecule TrkB Agonist 7, 8-Dihydroxyflavone Decreases Hippocampal Newborn Neuron Death After Traumatic Brain Injury.

Chen L, Gao X, Zhao S, Hu W, Chen J.

J Neuropathol Exp Neurol. 2015 Jun;74(6):557-67. doi: 10.1097/NEN.0000000000000199.


7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats.

Andero R, Daviu N, Escorihuela RM, Nadal R, Armario A.

Hippocampus. 2012 Mar;22(3):399-408. doi: 10.1002/hipo.20906. Epub 2010 Dec 6.


7,8-dihydroxyflavone, a small-molecule tropomyosin-related kinase B (TrkB) agonist, attenuates cerebral ischemia and reperfusion injury in rats.

Wang B, Wu N, Liang F, Zhang S, Ni W, Cao Y, Xia D, Xi H.

J Mol Histol. 2014 Apr;45(2):129-40. doi: 10.1007/s10735-013-9539-y. Epub 2013 Sep 13.


Tripchlorolide improves age-associated cognitive deficits by reversing hippocampal synaptic plasticity impairment and NMDA receptor dysfunction in SAMP8 mice.

Lin N, Pan XD, Chen AQ, Zhu YG, Wu M, Zhang J, Chen XC.

Behav Brain Res. 2014 Jan 1;258:8-18. doi: 10.1016/j.bbr.2013.10.010. Epub 2013 Oct 17.


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