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Items: 1 to 20 of 139


PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor.

Madishetti S, Schneble N, König C, Hirsch E, Schulz S, Müller JP, Wetzker R.

Br J Pharmacol. 2014 Jul;171(13):3328-37. doi: 10.1111/bph.12698.


Stimulation of peripheral kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kγ/AKT/nNOS/NO signaling pathway.

Cunha TM, Souza GR, Domingues AC, Carreira EU, Lotufo CM, Funez MI, Verri WA Jr, Cunha FQ, Ferreira SH.

Mol Pain. 2012 Feb 8;8:10. doi: 10.1186/1744-8069-8-10.


Activation of Mas oncogene-related gene (Mrg) C receptors enhances morphine-induced analgesia through modulation of coupling of μ-opioid receptor to Gi-protein in rat spinal dorsal horn.

Wang D, Chen T, Zhou X, Couture R, Hong Y.

Neuroscience. 2013 Dec 3;253:455-64. doi: 10.1016/j.neuroscience.2013.08.069. Epub 2013 Sep 14.


Remifentanil produces cross-desensitization and tolerance with morphine on the mu-opioid receptor.

Nowoczyn M, Marie N, Coulbault L, Hervault M, Davis A, Hanouz JL, Allouche S.

Neuropharmacology. 2013 Oct;73:368-79. doi: 10.1016/j.neuropharm.2013.06.010. Epub 2013 Jun 21.


Modulation of mu opioid receptor desensitization in peripheral sensory neurons by phosphoinositide 3-kinase gamma.

König C, Gavrilova-Ruch O, von Banchet GS, Bauer R, Grün M, Hirsch E, Rubio I, Schulz S, Heinemann SH, Schaible HG, Wetzker R.

Neuroscience. 2010 Aug 11;169(1):449-54. doi: 10.1016/j.neuroscience.2010.04.068. Epub 2010 May 6.


Morphine mediates a proinflammatory phenotype via μ-opioid receptor-PKCɛ-Akt-ERK1/2 signaling pathway in activated microglial cells.

Merighi S, Gessi S, Varani K, Fazzi D, Stefanelli A, Borea PA.

Biochem Pharmacol. 2013 Aug 15;86(4):487-96. doi: 10.1016/j.bcp.2013.05.027. Epub 2013 Jun 21.


Morphine inhibits acid-sensing ion channel currents in rat dorsal root ganglion neurons.

Cai Q, Qiu CY, Qiu F, Liu TT, Qu ZW, Liu YM, Hu WP.

Brain Res. 2014 Mar 20;1554:12-20. doi: 10.1016/j.brainres.2014.01.042. Epub 2014 Feb 1.


Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.

Guo D, Kassiri Z, Basu R, Chow FL, Kandalam V, Damilano F, Liang W, Izumo S, Hirsch E, Penninger JM, Backx PH, Oudit GY.

Circ Res. 2010 Nov 12;107(10):1275-89. doi: 10.1161/CIRCRESAHA.110.229054. Epub 2010 Sep 16.


Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits.

Mostany R, Díaz A, Valdizán EM, Rodríguez-Muñoz M, Garzón J, Hurlé MA.

Neuropharmacology. 2008 May;54(6):989-97. doi: 10.1016/j.neuropharm.2008.02.004. Epub 2008 Feb 16.


Hydrogen sulfide attenuates opioid dependence by suppression of adenylate cyclase/cAMP pathway.

Yang HY, Wu ZY, Wood M, Whiteman M, Bian JS.

Antioxid Redox Signal. 2014 Jan 1;20(1):31-41. doi: 10.1089/ars.2012.5119. Epub 2013 Jul 11.


STAT5A interacts with and is phosphorylated upon activation of the mu-opioid receptor.

Mazarakou G, Georgoussi Z.

J Neurochem. 2005 May;93(4):918-31.


Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of mu-opioid receptors from Gs-protein to coupling to Gi-protein.

Tsai RY, Tai YH, Tzeng JI, Cherng CH, Yeh CC, Wong CS.

Neuroscience. 2009 Dec 1;164(2):435-43. doi: 10.1016/j.neuroscience.2009.08.015. Epub 2009 Aug 12.


Contribution of adrenomedullin to the switch of G protein-coupled μ-opioid receptors from Gi to Gs in the spinal dorsal horn following chronic morphine exposure in rats.

Wang D, Zeng J, Li Q, Huang J, Couture R, Hong Y.

Br J Pharmacol. 2016 Apr;173(7):1196-207. doi: 10.1111/bph.13419. Epub 2016 Feb 25.


mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control.

Polakiewicz RD, Schieferl SM, Gingras AC, Sonenberg N, Comb MJ.

J Biol Chem. 1998 Sep 4;273(36):23534-41.


Activation of PI3Kγ/Akt pathway mediates bone cancer pain in rats.

Guan X, Fu Q, Xiong B, Song Z, Shu B, Bu H, Xu B, Manyande A, Cao F, Tian Y.

J Neurochem. 2015 Aug;134(3):590-600. doi: 10.1111/jnc.13139. Epub 2015 Jun 4.


Adenylylcyclase supersensitization in mu-opioid receptor-transfected Chinese hamster ovary cells following chronic opioid treatment.

Avidor-Reiss T, Bayewitch M, Levy R, Matus-Leibovitch N, Nevo I, Vogel Z.

J Biol Chem. 1995 Dec 15;270(50):29732-8.

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