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Items: 1 to 20 of 99

1.

Chiral Effect of a Phe Residue in Position 3 of the Dmt1-L(or D)-Tic2 Analogues on Opioid Functional Activities.

Lee YS, Qu HC, Davis P, Ma SW, Vardanyan R, Lai J, Porreca F, Hruby VJ.

ACS Med Chem Lett. 2013 Jul 11;4(7):656-659.

2.

Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.

Salvadori S, Balboni G, Guerrini R, Tomatis R, Bianchi C, Bryant SD, Cooper PS, Lazarus LH.

J Med Chem. 1997 Sep 12;40(19):3100-8.

PMID:
9301674
3.

Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism.

Balboni G, Salvadori S, Guerrini R, Negri L, Giannini E, Bryant SD, Jinsmaa Y, Lazarus LH.

J Med Chem. 2004 Jul 29;47(16):4066-71.

PMID:
15267245
4.

N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile.

Weltrowska G, Nguyen TM, Chung NN, Wilkes BC, Schiller PW.

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5082-5. doi: 10.1016/j.bmcl.2013.07.036. Epub 2013 Jul 23.

5.

Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.

Balboni G, Guerrini R, Salvadori S, Bianchi C, Rizzi D, Bryant SD, Lazarus LH.

J Med Chem. 2002 Jan 31;45(3):713-20.

PMID:
11806723
6.

Novel diastereomeric opioid tetrapeptides exhibit differing pharmacological activity profiles.

Ioja E, Tourwé D, Kertész I, Tóth G, Borsodi A, Benyhe S.

Brain Res Bull. 2007 Sep 14;74(1-3):119-29. Epub 2007 Jun 8.

PMID:
17683797
7.

Bioactivity of new mu and delta opioid peptides.

Capasso A.

Med Chem. 2007 Sep;3(5):480-7.

PMID:
17897075
8.

Delta opioidmimetic antagonists: prototypes for designing a new generation of ultraselective opioid peptides.

Salvadori S, Attila M, Balboni G, Bianchi C, Bryant SD, Crescenzi O, Guerrini R, Picone D, Tancredi T, Temussi PA, et al.

Mol Med. 1995 Sep;1(6):678-89.

9.

Opioid diketopiperazines: synthesis and activity of a prototypic class of opioid antagonists.

Balboni G, Guerrini R, Salvadori S, Tomatis R, Bryant SD, Bianchi C, Attila M, Lazarus LH.

Biol Chem. 1997 Jan;378(1):19-29.

PMID:
9049061
10.

Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.

Balboni G, Salvadori S, Guerrini R, Negri L, Giannini E, Jinsmaa Y, Bryant SD, Lazarus LH.

J Med Chem. 2002 Dec 5;45(25):5556-63.

PMID:
12459023
11.

Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.

Balboni G, Onnis V, Congiu C, Zotti M, Sasaki Y, Ambo A, Bryant SD, Jinsmaa Y, Lazarus LH, Trapella C, Salvadori S.

J Med Chem. 2006 Sep 7;49(18):5610-7.

12.

Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.

Ballet S, Feytens D, Wachter RD, Vlaeminck MD, Marczak ED, Salvadori S, Graaf Cd, Rognan D, Negri L, Lattanzi R, Lazarus LH, Tourwé D, Balboni G.

Bioorg Med Chem Lett. 2009 Jan 15;19(2):433-7. doi: 10.1016/j.bmcl.2008.11.051. Epub 2008 Nov 19.

13.

Further studies on the Dmt-Tic pharmacophore: hydrophobic substituents at the C-terminus endow delta antagonists to manifest mu agonism or mu antagonism.

Salvadori S, Guerrini R, Balboni G, Bianchi C, Bryant SD, Cooper PS, Lazarus LH.

J Med Chem. 1999 Dec 2;42(24):5010-9.

PMID:
10585210
14.

Dmt and opioid peptides: a potent alliance.

Bryant SD, Jinsmaa Y, Salvadori S, Okada Y, Lazarus LH.

Biopolymers. 2003;71(2):86-102. Review.

PMID:
12767112
15.

Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.

Balboni G, Fiorini S, Baldisserotto A, Trapella C, Sasaki Y, Ambo A, Marczak ED, Lazarus LH, Salvadori S.

J Med Chem. 2008 Aug 28;51(16):5109-17. doi: 10.1021/jm800587e. Epub 2008 Aug 5.

16.
17.

The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists.

Schiller PW, Weltrowska G, Berezowska I, Nguyen TM, Wilkes BC, Lemieux C, Chung NN.

Biopolymers. 1999;51(6):411-25. Review.

PMID:
10797230
18.

Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists.

Li T, Fujita Y, Shiotani K, Miyazaki A, Tsuda Y, Ambo A, Sasaki Y, Jinsmaa Y, Marczak E, Bryant SD, Salvadori S, Lazarus LH, Okada Y.

J Med Chem. 2005 Dec 15;48(25):8035-44.

PMID:
16335927
19.

Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists.

Tóth G, Ioja E, Tömböly C, Ballet S, Tourwé D, Péter A, Martinek T, Chung NN, Schiller PW, Benyhe S, Borsodi A.

J Med Chem. 2007 Jan 25;50(2):328-33.

PMID:
17228874
20.

Effect of aromatic amino acid substitutions in the 3-position of cyclic beta-casomorphin analogues on mu-opioid agonist/delta-opioid antagonist properties.

Schmidt R, Wilkes BC, Chung NN, Lemieux C, Schiller PW.

Int J Pept Protein Res. 1996 Nov;48(5):411-9.

PMID:
8956074

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