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Items: 1 to 20 of 114


A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila.

Ashton-Beaucage D, Udell CM, Gendron P, Sahmi M, Lefrançois M, Baril C, Guenier AS, Duchaine J, Lamarre D, Lemieux S, Therrien M.

PLoS Biol. 2014 Mar 18;12(3):e1001809. doi: 10.1371/journal.pbio.1001809. eCollection 2014 Mar.


Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling.

Friedman AA, Tucker G, Singh R, Yan D, Vinayagam A, Hu Y, Binari R, Hong P, Sun X, Porto M, Pacifico S, Murali T, Finley RL Jr, Asara JM, Berger B, Perrimon N.

Sci Signal. 2011 Oct 25;4(196):rs10. doi: 10.1126/scisignal.2002029.


Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development.

Shilo A, Ben Hur V, Denichenko P, Stein I, Pikarsky E, Rauch J, Kolch W, Zender L, Karni R.

RNA. 2014 Apr;20(4):505-15. doi: 10.1261/rna.042259.113. Epub 2014 Feb 26.


The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.

Ashton-Beaucage D, Lemieux C, Udell CM, Sahmi M, Rochette S, Therrien M.

PLoS Biol. 2016 Aug 23;14(8):e1002539. doi: 10.1371/journal.pbio.1002539. eCollection 2016 Aug.


KSR is a scaffold required for activation of the ERK/MAPK module.

Roy F, Laberge G, Douziech M, Ferland-McCollough D, Therrien M.

Genes Dev. 2002 Feb 15;16(4):427-38.


Kinase gene haplotypes and gene-gene interactions in the Ras-Raf-MAPK signaling pathway: association with antidepressant remission.

Wang CJ, Zhang ZJ, Xu Z, Shi YY, Pu MJ, Zheng Z, Wang XZ, Zhang YM, Li LJ.

Int Clin Psychopharmacol. 2013 Sep;28(5):245-54. doi: 10.1097/YIC.0b013e328362c89f.


Apical accumulation of the Sevenless receptor tyrosine kinase during Drosophila eye development is promoted by the small GTPase Rap1.

Baril C, Lefrançois M, Sahmi M, Knævelsrud H, Therrien M.

Genetics. 2014 Aug;197(4):1237-50. doi: 10.1534/genetics.114.166272. Epub 2014 Jun 3.


Ras/MEK/MAPK-mediated regulation of heparin sulphate proteoglycans promotes retinal fate in the Drosophila eye-antennal disc.

Fernandes VM, Pradhan-Sundd T, Blaquiere JA, Verheyen EM.

Dev Biol. 2015 Jun 1;402(1):109-18. doi: 10.1016/j.ydbio.2015.03.014. Epub 2015 Apr 4.


In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling.

Khoo P, Allan K, Willoughby L, Brumby AM, Richardson HE.

Dis Model Mech. 2013 May;6(3):661-78. doi: 10.1242/dmm.010066. Epub 2013 Jan 11.


Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.

Roberts PJ, Der CJ.

Oncogene. 2007 May 14;26(22):3291-310. Review.


The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila.

Ashton-Beaucage D, Udell CM, Lavoie H, Baril C, Lefrançois M, Chagnon P, Gendron P, Caron-Lizotte O, Bonneil E, Thibault P, Therrien M.

Cell. 2010 Oct 15;143(2):251-62. doi: 10.1016/j.cell.2010.09.014.


Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway.

Woods D, Cherwinski H, Venetsanakos E, Bhat A, Gysin S, Humbert M, Bray PF, Saylor VL, McMahon M.

Mol Cell Biol. 2001 May;21(9):3192-205.


Bimodal regulation of RAF by CNK in Drosophila.

Douziech M, Roy F, Laberge G, Lefrançois M, Armengod AV, Therrien M.

EMBO J. 2003 Oct 1;22(19):5068-78.


Functional analysis of CNK in RAS signaling.

Therrien M, Wong AM, Kwan E, Rubin GM.

Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13259-63.


The PP2C Alphabet is a negative regulator of stress-activated protein kinase signaling in Drosophila.

Baril C, Sahmi M, Ashton-Beaucage D, Stronach B, Therrien M.

Genetics. 2009 Feb;181(2):567-79. doi: 10.1534/genetics.108.096461. Epub 2008 Dec 8.


Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration.

Rajalingam K, Wunder C, Brinkmann V, Churin Y, Hekman M, Sievers C, Rapp UR, Rudel T.

Nat Cell Biol. 2005 Aug;7(8):837-43. Epub 2005 Jul 24.

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