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Effects of selective and non-selective glucocorticoid receptor II antagonists on rapid-onset diabetes in young rats.

Beaudry JL, Dunford EC, Teich T, Zaharieva D, Hunt H, Belanoff JK, Riddell MC.

PLoS One. 2014 Mar 18;9(3):e91248. doi: 10.1371/journal.pone.0091248. eCollection 2014.


Binge-like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective.

Cippitelli A, Damadzic R, Hamelink C, Brunnquell M, Thorsell A, Heilig M, Eskay RL.

Addict Biol. 2014 Jan;19(1):27-36. doi: 10.1111/j.1369-1600.2012.00451.x. Epub 2012 Apr 13.


Voluntary exercise improves metabolic profile in high-fat fed glucocorticoid-treated rats.

Beaudry JL, Dunford EC, Leclair E, Mandel ER, Peckett AJ, Haas TL, Riddell MC.

J Appl Physiol (1985). 2015 Jun 1;118(11):1331-43. doi: 10.1152/japplphysiol.00467.2014. Epub 2015 Mar 19.


Glucocorticoid antagonism limits adiposity rebound and glucose intolerance in young male rats following the cessation of daily exercise and caloric restriction.

Teich T, Dunford EC, Porras DP, Pivovarov JA, Beaudry JL, Hunt H, Belanoff JK, Riddell MC.

Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E56-68. doi: 10.1152/ajpendo.00490.2015. Epub 2016 May 3.


A rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding.

Shpilberg Y, Beaudry JL, D'Souza A, Campbell JE, Peckett A, Riddell MC.

Dis Model Mech. 2012 Sep;5(5):671-80. doi: 10.1242/dmm.008912. Epub 2011 Dec 19.


Differential effect of glucocorticoid receptor antagonists on glucocorticoid receptor nuclear translocation and DNA binding.

Spiga F, Knight DM, Droste SK, Conway-Campbell B, Kershaw Y, MacSweeney CP, Thomson FJ, Craighead M, Peeters BW, Lightman SL.

J Psychopharmacol. 2011 Feb;25(2):211-21. doi: 10.1177/0269881109348175. Epub 2010 Jan 21.


Chronic treatment with the glucocorticoid receptor antagonist RU486 inhibits diabetes-induced enhancement of experimental periodontitis.

Breivik T, Gundersen Y, Gjermo P, Opstad PK.

J Periodontal Res. 2014 Feb;49(1):36-44. doi: 10.1111/jre.12076. Epub 2013 Apr 16.


Increased hypothalamic neuropeptide Y concentration or hyperphagia in streptozotocin-diabetic rats are not mediated by glucocorticoids.

Dryden S, Burns SJ, Frankish HM, Williams G.

Eur J Pharmacol. 1997 Dec 11;340(2-3):221-5.


Effects of the glucocorticoid antagonist RU486 in spontaneously hypertensive and Sprague Dawley rats.

Soro A, Panarelli M, Holloway CD, Fraser R, Kenyon CJ.

J Endocrinol Invest. 1995 Dec;18(11):833-9.


Glucocorticoid-induced hypertension and cardiac injury: effects of mineralocorticoid and glucocorticoid receptor antagonism.

Hattori T, Murase T, Iwase E, Takahashi K, Ohtake M, Tsuboi K, Ohtake M, Miyachi M, Murohara T, Nagata K.

Nagoya J Med Sci. 2013 Feb;75(1-2):81-92.


Exogenous glucocorticoids and a high-fat diet cause severe hyperglycemia and hyperinsulinemia and limit islet glucose responsiveness in young male Sprague-Dawley rats.

Beaudry JL, D'souza AM, Teich T, Tsushima R, Riddell MC.

Endocrinology. 2013 Sep;154(9):3197-208. doi: 10.1210/en.2012-2114. Epub 2013 Jun 13.


Attenuation of cold stress-induced exacerbation of cardiac and adipose tissue pathology and metabolic disorders in a rat model of metabolic syndrome by the glucocorticoid receptor antagonist RU486.

Nagasawa K, Matsuura N, Takeshita Y, Ito S, Sano Y, Yamada Y, Uchinaka A, Murohara T, Nagata K.

Nutr Diabetes. 2016 Apr 25;6:e207. doi: 10.1038/nutd.2016.14.


Differential effects of the new glucocorticoid receptor antagonist ORG 34517 and RU486 (mifepristone) on glucocorticoid receptor nuclear translocation in the AtT20 cell line.

Peeters BW, Ruigt GS, Craighead M, Kitchener P.

Ann N Y Acad Sci. 2008 Dec;1148:536-41. doi: 10.1196/annals.1410.072.


The selective glucocorticoid receptor antagonist CORT 108297 decreases neuroendocrine stress responses and immobility in the forced swim test.

Solomon MB, Wulsin AC, Rice T, Wick D, Myers B, McKlveen J, Flak JN, Ulrich-Lai Y, Herman JP.

Horm Behav. 2014 Apr;65(4):363-71. doi: 10.1016/j.yhbeh.2014.02.002. Epub 2014 Feb 11.


Pharmacological manipulation of glucocorticoid receptors differentially affects cocaine self-administration in environmentally enriched and isolated rats.

Hofford RS, Prendergast MA, Bardo MT.

Behav Brain Res. 2015 Apr 15;283:196-202. doi: 10.1016/j.bbr.2015.01.049. Epub 2015 Feb 2.


Mifepristone protects CA1 hippocampal neurons following traumatic brain injury in rat.

McCullers DL, Sullivan PG, Scheff SW, Herman JP.

Neuroscience. 2002;109(2):219-30.


Chronic blockade of hindbrain glucocorticoid receptors reduces blood pressure responses to novel stress and attenuates adaptation to repeated stress.

Bechtold AG, Patel G, Hochhaus G, Scheuer DA.

Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1445-54. doi: 10.1152/ajpregu.00095.2008. Epub 2009 Mar 11.


Corticosterone rapidly increases thorns of CA3 neurons via synaptic/extranuclear glucocorticoid receptor in rat hippocampus.

Yoshiya M, Komatsuzaki Y, Hojo Y, Ikeda M, Mukai H, Hatanaka Y, Murakami G, Kawata M, Kimoto T, Kawato S.

Front Neural Circuits. 2013 Nov 27;7:191. doi: 10.3389/fncir.2013.00191. eCollection 2013.


Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator.

Zalachoras I, Houtman R, Atucha E, Devos R, Tijssen AM, Hu P, Lockey PM, Datson NA, Belanoff JK, Lucassen PJ, Joƫls M, de Kloet ER, Roozendaal B, Hunt H, Meijer OC.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7910-5. doi: 10.1073/pnas.1219411110. Epub 2013 Apr 23.

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