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Items: 1 to 20 of 97

1.

Nine of 16 stereoisomeric polyhydroxylated proline amides are potent β-N-acetylhexosaminidase inhibitors.

Ayers BJ, Glawar AF, Martínez RF, Ngo N, Liu Z, Fleet GW, Butters TD, Nash RJ, Yu CY, Wormald MR, Nakagawa S, Adachi I, Kato A, Jenkinson SF.

J Org Chem. 2014 Apr 18;79(8):3398-409. doi: 10.1021/jo500157p. Epub 2014 Apr 7.

PMID:
24641544
2.

Synthesis of the enantiomers of XYLNAc and LYXNAc: comparison of β-N-acetylhexosaminidase inhibition by the 8 stereoisomers of 2-N-acetylamino-1,2,4-trideoxy-1,4-iminopentitols.

Crabtree EV, Martínez RF, Nakagawa S, Adachi I, Butters TD, Kato A, Fleet GW, Glawar AF.

Org Biomol Chem. 2014 Jun 21;12(23):3932-43. doi: 10.1039/c4ob00097h.

PMID:
24802185
3.

Effects of ring contraction on the conformational preferences of α-substituted proline analogs.

Revilla-López G, Warren JG, Torras J, Jiménez AI, Cativiela C, Alemán C.

Biopolymers. 2012;98(2):98-110. doi: 10.1002/bip.21716. Epub 2011 Sep 6.

PMID:
21898364
4.

Design and synthesis of acetamido tri- and tetra-hydroxyazepanes: potent and selective beta-N-acetylhexosaminidase inhibitors.

Li H, Marcelo F, Bello C, Vogel P, Butters TD, Rauter AP, Zhang Y, Sollogoub M, Blériot Y.

Bioorg Med Chem. 2009 Aug 1;17(15):5598-604. doi: 10.1016/j.bmc.2009.06.022. Epub 2009 Jun 17.

PMID:
19592259
5.

Synthesis of eight stereoisomers of pochonicine: nanomolar inhibition of β-N-acetylhexosaminidases.

Zhu JS, Nakagawa S, Chen W, Adachi I, Jia YM, Hu XG, Fleet GW, Wilson FX, Nitoda T, Horne G, van Well R, Kato A, Yu CY.

J Org Chem. 2013 Oct 18;78(20):10298-309. doi: 10.1021/jo401694e. Epub 2013 Sep 30.

PMID:
24032658
6.
7.

Design, synthesis, and biological evaluation of enantiomeric beta-N-acetylhexosaminidase inhibitors LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff disease.

Rountree JS, Butters TD, Wormald MR, Boomkamp SD, Dwek RA, Asano N, Ikeda K, Evinson EL, Nash RJ, Fleet GW.

ChemMedChem. 2009 Mar;4(3):378-92. doi: 10.1002/cmdc.200800350.

PMID:
19145603
9.

Highly efficient and enantioselective biotransformations of racemic azetidine-2-carbonitriles and their synthetic applications.

Leng DH, Wang DX, Pan J, Huang ZT, Wang MX.

J Org Chem. 2009 Aug 21;74(16):6077-82. doi: 10.1021/jo9011656.

PMID:
19627128
11.

3-Hydroxyazetidine carboxylic acids: non-proteinogenic amino acids for medicinal chemists.

Glawar AF, Jenkinson SF, Thompson AL, Nakagawa S, Kato A, Butters TD, Fleet GW.

ChemMedChem. 2013 Apr;8(4):658-66. doi: 10.1002/cmdc.201200541. Epub 2013 Mar 6.

PMID:
23468173
12.
13.

Azetidine-2-carboxylic acid in garden beets (Beta vulgaris).

Rubenstein E, Zhou H, Krasinska KM, Chien A, Becker CH.

Phytochemistry. 2006 May;67(9):898-903. Epub 2006 Mar 3.

PMID:
16516254
14.

Misincorporation of the proline homologue Aze (azetidine-2-carboxylic acid) into recombinant myelin basic protein.

Bessonov K, Bamm VV, Harauz G.

Phytochemistry. 2010 Apr;71(5-6):502-7. doi: 10.1016/j.phytochem.2009.12.010. Epub 2010 Jan 11.

PMID:
20064647
15.

Complementary stereochemical outcomes in proline-based self-regenerations of stereocenters.

Knight BJ, Stache EE, Ferreira EM.

Org Lett. 2014 Jan 17;16(2):432-5. doi: 10.1021/ol403320d. Epub 2013 Dec 30.

PMID:
24377839
16.

Design and synthesis of a 3,4-dehydroproline amide discovery library.

Werner S, Kasi D, Brummond KM.

J Comb Chem. 2007 Jul-Aug;9(4):677-83. Epub 2007 Jun 14.

PMID:
17567173
17.

Copper-catalyzed N-arylation of amides using (S)-N-methylpyrrolidine-2-carboxylate as the ligand.

Wang C, Liu L, Wang W, Ma DS, Zhang H.

Molecules. 2010 Mar 2;15(3):1154-60. doi: 10.3390/molecules15031154.

18.

β-N-acetylhexosaminidase: what's in a name…?

Slámová K, Bojarová P, Petrásková L, Kren V.

Biotechnol Adv. 2010 Nov-Dec;28(6):682-93. doi: 10.1016/j.biotechadv.2010.04.004. Epub 2010 May 9. Review.

PMID:
20438826
19.

Palladium-catalyzed direct intermolecular α-arylation of amides with aryl chlorides.

Zheng B, Jia T, Walsh PJ.

Org Lett. 2013 Aug 16;15(16):4190-3. doi: 10.1021/ol4019002. Epub 2013 Aug 5.

PMID:
23909856
20.

Practical asymmetric preparation of azetidine-2-carboxylic acid.

Couty F, Evano G, Vargas-Sanchez M, Bouzas G.

J Org Chem. 2005 Oct 28;70(22):9028-31.

PMID:
16238345

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