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Items: 1 to 20 of 142


Dual regulation of G proteins and the G-protein-activated K+ channels by lithium.

Farhy Tselnicker I, Tsemakhovich V, Rishal I, Kahanovitch U, Dessauer CW, Dascal N.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):5018-23. doi: 10.1073/pnas.1316425111. Epub 2014 Mar 17.


A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ.

Yakubovich D, Berlin S, Kahanovitch U, Rubinstein M, Farhy-Tselnicker I, Styr B, Keren-Raifman T, Dessauer CW, Dascal N.

PLoS Comput Biol. 2015 Nov 6;11(11):e1004598. doi: 10.1371/journal.pcbi.1004598. eCollection 2015 Nov.


Divergent regulation of GIRK1 and GIRK2 subunits of the neuronal G protein gated K+ channel by GalphaiGDP and Gbetagamma.

Rubinstein M, Peleg S, Berlin S, Brass D, Keren-Raifman T, Dessauer CW, Ivanina T, Dascal N.

J Physiol. 2009 Jul 15;587(Pt 14):3473-91. doi: 10.1113/jphysiol.2009.173229. Epub 2009 May 26.


Recruitment of Gβγ controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1.

Kahanovitch U, Tsemakhovich V, Berlin S, Rubinstein M, Styr B, Castel R, Peleg S, Tabak G, Dessauer CW, Ivanina T, Dascal N.

J Physiol. 2014 Dec 15;592(24):5373-90. doi: 10.1113/jphysiol.2014.283218. Epub 2014 Nov 10.


The Roles of Gβγ and Gα in Gating and Regulation of GIRK Channels.

Dascal N, Kahanovitch U.

Int Rev Neurobiol. 2015;123:27-85. doi: 10.1016/bs.irn.2015.06.001. Epub 2015 Jul 26. Review.


Galphai3 primes the G protein-activated K+ channels for activation by coexpressed Gbetagamma in intact Xenopus oocytes.

Rubinstein M, Peleg S, Berlin S, Brass D, Dascal N.

J Physiol. 2007 May 15;581(Pt 1):17-32. Epub 2007 Feb 8.


Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunits.

Berlin S, Tsemakhovich VA, Castel R, Ivanina T, Dessauer CW, Keren-Raifman T, Dascal N.

J Biol Chem. 2011 Sep 23;286(38):33223-35. doi: 10.1074/jbc.M111.271056. Epub 2011 Jul 27.


Galphai1 and Galphai3 differentially interact with, and regulate, the G protein-activated K+ channel.

Ivanina T, Varon D, Peleg S, Rishal I, Porozov Y, Dessauer CW, Keren-Raifman T, Dascal N.

J Biol Chem. 2004 Apr 23;279(17):17260-8. Epub 2004 Feb 12.


Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex.

Clancy SM, Fowler CE, Finley M, Suen KF, Arrabit C, Berton F, Kosaza T, Casey PJ, Slesinger PA.

Mol Cell Neurosci. 2005 Feb;28(2):375-89.


Lithium reduces the span of G protein-activated K+ (GIRK) channel inhibition in hippocampal neurons.

Dascal N, Rubinstein M.

Bipolar Disord. 2017 Sep 12. doi: 10.1111/bdi.12536. [Epub ahead of print]


Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein beta gamma subunits.

Lei Q, Jones MB, Talley EM, Schrier AD, McIntire WE, Garrison JC, Bayliss DA.

Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9771-6.


Gbetagamma-dependent and Gbetagamma-independent basal activity of G protein-activated K+ channels.

Rishal I, Porozov Y, Yakubovich D, Varon D, Dascal N.

J Biol Chem. 2005 Apr 29;280(17):16685-94. Epub 2005 Feb 23.


Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3.

Jelacic TM, Kennedy ME, Wickman K, Clapham DE.

J Biol Chem. 2000 Nov 17;275(46):36211-6.


Molecular mechanisms mediating inhibition of G protein-coupled inwardly-rectifying K+ channels.

Lei Q, Jones MB, Talley EM, Garrison JC, Bayliss DA.

Mol Cells. 2003 Feb 28;15(1):1-9. Review.


Activation and inhibition of neuronal G protein-gated inwardly rectifying K(+) channels by P2Y nucleotide receptors.

Filippov AK, Fernández-Fernández JM, Marsh SJ, Simon J, Barnard EA, Brown DA.

Mol Pharmacol. 2004 Sep;66(3):468-77.


Structural basis for modulation of gating property of G protein-gated inwardly rectifying potassium ion channel (GIRK) by i/o-family G protein α subunit (Gαi/o).

Mase Y, Yokogawa M, Osawa M, Shimada I.

J Biol Chem. 2012 Jun 1;287(23):19537-49. doi: 10.1074/jbc.M112.353888. Epub 2012 Apr 16.

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