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Cutting edge: A double-mutant knockin of the CD28 YMNM and PYAP motifs reveals a critical role for the YMNM motif in regulation of T cell proliferation and Bcl-xL expression.

Boomer JS, Deppong CM, Shah DD, Bricker TL, Green JM.

J Immunol. 2014 Apr 15;192(8):3465-9. doi: 10.4049/jimmunol.1301240. Epub 2014 Mar 17.


Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulation.

Dodson LF, Boomer JS, Deppong CM, Shah DD, Sim J, Bricker TL, Russell JH, Green JM.

Mol Cell Biol. 2009 Jul;29(13):3710-21. doi: 10.1128/MCB.01869-08. Epub 2009 Apr 27.


A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant.

Friend LD, Shah DD, Deppong C, Lin J, Bricker TL, Juehne TI, Rose CM, Green JM.

J Exp Med. 2006 Sep 4;203(9):2121-33. Epub 2006 Aug 14.


CD28 signaling in primary CD4(+) T cells: identification of both tyrosine phosphorylation-dependent and phosphorylation-independent pathways.

Ogawa S, Watanabe M, Sakurai Y, Inutake Y, Watanabe S, Tai X, Abe R.

Int Immunol. 2013 Dec;25(12):671-81. doi: 10.1093/intimm/dxt028. Epub 2013 Sep 18.


CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs.

Pagán AJ, Pepper M, Chu HH, Green JM, Jenkins MK.

J Immunol. 2012 Sep 15;189(6):2909-17. doi: 10.4049/jimmunol.1103231. Epub 2012 Aug 15.


Cutting edge: distinct motifs within CD28 regulate T cell proliferation and induction of Bcl-XL.

Burr JS, Savage ND, Messah GE, Kimzey SL, Shaw AS, Arch RH, Green JM.

J Immunol. 2001 May 1;166(9):5331-5.


CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation.

Sperling AI, Auger JA, Ehst BD, Rulifson IC, Thompson CB, Bluestone JA.

J Immunol. 1996 Nov 1;157(9):3909-17.


Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo.

Harada Y, Tokushima M, Matsumoto Y, Ogawa S, Otsuka M, Hayashi K, Weiss BD, June CH, Abe R.

J Immunol. 2001 Mar 15;166(6):3797-803.


Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3-kinase in primary peripheral T cells.

Gogishvili T, Elias F, Emery JL, McPherson K, Okkenhaug K, Hünig T, Dennehy KM.

Eur J Immunol. 2008 Sep;38(9):2528-33. doi: 10.1002/eji.200838223.


Novel role of phosphatidylinositol 3-kinase in CD28-mediated costimulation.

Harada Y, Tanabe E, Watanabe R, Weiss BD, Matsumoto A, Ariga H, Koiwai O, Fukui Y, Kubo M, June CH, Abe R.

J Biol Chem. 2001 Mar 23;276(12):9003-8. Epub 2000 Dec 11.


CD28 Promotes Plasma Cell Survival, Sustained Antibody Responses, and BLIMP-1 Upregulation through Its Distal PYAP Proline Motif.

Rozanski CH, Utley A, Carlson LM, Farren MR, Murray M, Russell LM, Nair JR, Yang Z, Brady W, Garrett-Sinha LA, Schoenberger SP, Green JM, Boise LH, Lee KP.

J Immunol. 2015 May 15;194(10):4717-28. doi: 10.4049/jimmunol.1402260. Epub 2015 Apr 1.


A point mutation in CD28 distinguishes proliferative signals from survival signals.

Okkenhaug K, Wu L, Garza KM, La Rose J, Khoo W, Odermatt B, Mak TW, Ohashi PS, Rottapel R.

Nat Immunol. 2001 Apr;2(4):325-32.


Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.

Tai X, Van Laethem F, Sharpe AH, Singer A.

Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13756-61. Epub 2007 Aug 16.


A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS).

Harada Y, Ohgai D, Watanabe R, Okano K, Koiwai O, Tanabe K, Toma H, Altman A, Abe R.

J Exp Med. 2003 Jan 20;197(2):257-62.


CD28 facilitates the generation of Foxp3(-) cytokine responsive regulatory T cell precursors.

Lio CW, Dodson LF, Deppong CM, Hsieh CS, Green JM.

J Immunol. 2010 Jun 1;184(11):6007-13. doi: 10.4049/jimmunol.1000019. Epub 2010 Apr 26.


Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation.

Watanabe R, Harada Y, Takeda K, Takahashi J, Ohnuki K, Ogawa S, Ohgai D, Kaibara N, Koiwai O, Tanabe K, Toma H, Sugamura K, Abe R.

J Immunol. 2006 Jul 15;177(2):1085-91.


Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice.

Heinly CS, Sempowski GD, Lee DM, Patel DD, McDermott PM, Scearce RM, Thompson CB, Haynes BF.

Int Immunol. 2001 Feb;13(2):157-66.


The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28.

Marengère LE, Okkenhaug K, Clavreul A, Couez D, Gibson S, Mills GB, Mak TW, Rottapel R.

J Immunol. 1997 Oct 1;159(7):3220-9. Erratum in: J Immunol 1999 Jul 15;163(2):1092.


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