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Items: 1 to 20 of 102

1.

Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.

Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S.

Nat Commun. 2014 Mar 18;5:3492. doi: 10.1038/ncomms4492.

2.

p21 protects "Super p53" mice from the radiation-induced gastrointestinal syndrome.

Sullivan JM, Jeffords LB, Lee CL, Rodrigues R, Ma Y, Kirsch DG.

Radiat Res. 2012 Mar;177(3):307-10. Epub 2011 Dec 13.

3.

Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21.

Leibowitz BJ, Qiu W, Liu H, Cheng T, Zhang L, Yu J.

Mol Cancer Res. 2011 May;9(5):616-25. doi: 10.1158/1541-7786.MCR-11-0052. Epub 2011 Mar 30.

4.

Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice.

Leibowitz BJ, Wei L, Zhang L, Ping X, Epperly M, Greenberger J, Cheng T, Yu J.

Nat Commun. 2014 Mar 18;5:3494. doi: 10.1038/ncomms4494.

5.

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation.

Wang X, Wei L, Cramer JM, Leibowitz BJ, Judge C, Epperly M, Greenberger J, Wang F, Li L, Stelzner MG, Dunn JC, Martin MG, Lagasse E, Zhang L, Yu J.

Sci Rep. 2015 Apr 10;5:8566. doi: 10.1038/srep08566.

6.

p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines.

Taura M, Eguma A, Suico MA, Shuto T, Koga T, Komatsu K, Komune T, Sato T, Saya H, Li JD, Kai H.

Mol Cell Biol. 2008 Nov;28(21):6557-67. doi: 10.1128/MCB.01202-08. Epub 2008 Sep 8.

7.

TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis.

Taura M, Fukuda R, Suico MA, Eguma A, Koga T, Shuto T, Sato T, Morino-Koga S, Kai H.

Cancer Sci. 2010 Jul;101(7):1610-7. doi: 10.1111/j.1349-7006.2010.01567.x. Epub 2010 Mar 13.

8.

Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis.

Qiu W, Leibowitz B, Zhang L, Yu J.

Oncogene. 2010 Mar 18;29(11):1622-32. doi: 10.1038/onc.2009.451. Epub 2009 Dec 7.

9.

TLR3, TRIF, and caspase 8 determine double-stranded RNA-induced epithelial cell death and survival in vivo.

McAllister CS, Lakhdari O, Pineton de Chambrun G, Gareau MG, Broquet A, Lee GH, Shenouda S, Eckmann L, Kagnoff MF.

J Immunol. 2013 Jan 1;190(1):418-27. doi: 10.4049/jimmunol.1202756. Epub 2012 Dec 3.

10.

PDGF-BB and bFGF ameliorate radiation-induced intestinal progenitor/stem cell apoptosis via Akt/p53 signaling in mice.

Liu Z, Liu H, Jiang J, Tan S, Yang Y, Zhan Y, Wu B.

Am J Physiol Gastrointest Liver Physiol. 2014 Dec 1;307(11):G1033-43. doi: 10.1152/ajpgi.00151.2014. Epub 2014 Oct 9.

11.

Toll-like receptor 3 (TLR3) induces apoptosis via death receptors and mitochondria by up-regulating the transactivating p63 isoform alpha (TAP63alpha).

Sun R, Zhang Y, Lv Q, Liu B, Jin M, Zhang W, He Q, Deng M, Liu X, Li G, Li Y, Zhou G, Xie P, Xie X, Hu J, Duan Z.

J Biol Chem. 2011 May 6;286(18):15918-28. doi: 10.1074/jbc.M110.178798. Epub 2011 Mar 2.

12.

Reduction of radiation-induced apoptosis by specific expression of Bcl-2 in normal cells.

Itamochi H, Yamasaki F, Sudo T, Takahashi T, Bartholomeusz C, Das S, Terakawa N, Ueno NT.

Cancer Gene Ther. 2006 May;13(5):451-9.

PMID:
16294215
13.

Toll-like receptor 3 plays a role in myocardial infarction and ischemia/reperfusion injury.

Lu C, Ren D, Wang X, Ha T, Liu L, Lee EJ, Hu J, Kalbfleisch J, Gao X, Kao R, Williams D, Li C.

Biochim Biophys Acta. 2014 Jan;1842(1):22-31. doi: 10.1016/j.bbadis.2013.10.006. Epub 2013 Oct 16.

14.

α-Tocopherol succinate protects mice against radiation-induced gastrointestinal injury.

Singh PK, Wise SY, Ducey EJ, Fatanmi OO, Elliott TB, Singh VK.

Radiat Res. 2012 Feb;177(2):133-45. Epub 2011 Oct 20.

PMID:
22013885
15.

p53-dependent radiation-induced crypt intestinal epithelial cells apoptosis is mediated in part through TNF-TNFR1 system.

Inagaki-Ohara K, Yada S, Takamura N, Reaves M, Yu X, Liu E, Rooney I, Nicholas S, Castro A, Ware CF, Green DR, Lin T.

Oncogene. 2001 Feb 15;20(7):812-8.

16.

p53 and cell-cycle-regulated protein expression in small intestinal cells after fast-neutron irradiation in mice.

Jee YH, Jeong WI, Kim TH, Hwang IS, Ahn MJ, Joo HG, Hong SH, Jeong KS.

Mol Cell Biochem. 2005 Feb;270(1-2):21-8.

PMID:
15792350
17.

dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8.

Estornes Y, Toscano F, Virard F, Jacquemin G, Pierrot A, Vanbervliet B, Bonnin M, Lalaoui N, Mercier-Gouy P, Pachéco Y, Salaun B, Renno T, Micheau O, Lebecque S.

Cell Death Differ. 2012 Sep;19(9):1482-94. doi: 10.1038/cdd.2012.22. Epub 2012 Mar 16.

18.

Toll-like receptor 3 (TLR3) protects retinal pigmented epithelium (RPE) cells from oxidative stress through a STAT3-dependent mechanism.

Patel AK, Hackam AS.

Mol Immunol. 2013 Jun;54(2):122-31. doi: 10.1016/j.molimm.2012.11.005. Epub 2012 Dec 23.

19.

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.

Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA.

Science. 2016 Nov 11;354(6313):765-768.

PMID:
27846608
20.

TLR3 deficiency protects against collagen degradation and medial destruction in murine atherosclerotic plaques.

Ishibashi M, Sayers S, D'Armiento JM, Tall AR, Welch CL.

Atherosclerosis. 2013 Jul;229(1):52-61. doi: 10.1016/j.atherosclerosis.2013.03.035. Epub 2013 Apr 9.

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