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Items: 1 to 20 of 104

1.

Synthesis and positive inotropic evaluation of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted piperazine moieties.

Ma LX, Cui BR, Wu Y, Liu JC, Cui X, Liu LP, Piao HR.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1737-41. doi: 10.1016/j.bmcl.2014.02.040. Epub 2014 Mar 3.

PMID:
24636107
2.

Synthesis and biological evaluation of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted benzylpiperazine moieties as positive inotropic agents.

Wu Y, Sun LP, Ma LX, Che J, Song MX, Cui X, Piao HR.

Chem Biol Drug Des. 2013 May;81(5):591-9. doi: 10.1111/cbdd.12101. Epub 2013 Mar 26.

PMID:
23279930
3.

Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties.

Wu Y, Ma LX, Niu TW, Cui X, Piao HR.

Bioorg Med Chem Lett. 2012 Jul 1;22(13):4229-32. doi: 10.1016/j.bmcl.2012.05.049. Epub 2012 May 18.

PMID:
22672796
4.

Synthesis and positive inotropic activity of N-(4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)-2-(piperazin-1-yl)acetamide derivatives.

Zhang CB, Cui X, Hong L, Quan ZS, Piao HR.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4606-9. doi: 10.1016/j.bmcl.2008.07.026. Epub 2008 Jul 12.

PMID:
18657421
5.

Synthesis and positive inotropic evaluation of (E)-2-(4-cinnamylpiperazin-1-yl)-N-(1-substituted-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides.

Wu Y, Ma LX, Niu TW, Meng FL, Cui X, Piao HR.

Arch Pharm (Weinheim). 2012 Dec;345(12):980-8. doi: 10.1002/ardp.201200159. Epub 2012 Sep 26.

PMID:
23015381
6.

Synthesis of 2-(4-substitutedbenzyl-[1,4]diazepan-1-yl)-n-(1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides as inotropic agents.

Ye BJ, Liu XK, Jiang SM, Cui X, Piao HR.

Chem Biol Drug Des. 2011 Jan;77(1):98-103. doi: 10.1111/j.1747-0285.2010.01057.x. Epub 2010 Nov 26.

PMID:
21114630
7.

Synthesis and antimicrobial activities of novel 1,2,4-triazolo [3,4-a] phthalazine derivatives.

Zhang QR, Xue DQ, He P, Shao KP, Chen PJ, Gu YF, Ren JL, Shan LH, Liu HM.

Bioorg Med Chem Lett. 2014 Feb 15;24(4):1236-8. doi: 10.1016/j.bmcl.2013.12.010. Epub 2013 Dec 7.

PMID:
24447849
8.

Synthesis and positive inotropic evaluation of 2-(4-(4-substituted benzyloxy)-3-methoxybenzyl)-1,4-diazepan-1-yl)-N-(4,5-dihydro-1-methyl[1,2,4]triazolo[4,3-a]quinolin-7-yl)-acetamides.

Li JY, Cui X, Liu XK, Hong L, Quan ZS, Piao HR.

Arch Pharm (Weinheim). 2008 Dec;341(12):794-9. doi: 10.1002/ardp.200800132.

PMID:
19006092
9.

Synthesis and in-vitro inotropic evaluation of 2-(4-substitutedbenzyl-1,4-diazepan-1-yl)-N-(4,5-dihydro-1-phenyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides.

Jiang SM, Ye BJ, Liu XK, Zhang TY, Cui X, Piao HR.

Arch Pharm (Weinheim). 2010 Nov;343(11-12):700-5. doi: 10.1002/ardp.201000032.

PMID:
21110340
10.

Synthesis and Positive Inotropic Activity of [1,2,4]Triazolo[4,3-a] Quinoxaline Derivatives Bearing Substituted Benzylpiperazine and Benzoylpiperazine Moieties.

Liu XK, Ma LX, Wei ZY, Cui X, Zhan S, Yin XM, Piao HR.

Molecules. 2017 Feb 11;22(2). pii: E273. doi: 10.3390/molecules22020273.

11.

Synthesis and anti-inflammatory activity evaluation of a novel series of 6-phenoxy-[1,2,4]triazolo[3,4-a]phthalazine-3-carboxamide derivatives.

Liu DC, Gong GH, Wei CX, Jin XJ, Quan ZS.

Bioorg Med Chem Lett. 2016 Mar 15;26(6):1576-9. doi: 10.1016/j.bmcl.2016.02.008. Epub 2016 Feb 4.

PMID:
26876930
12.

Synthesis of new triazole acetamides with inotropic effects.

Wu Y, Ma LX, Sun LP, Song MX, Cui X, Piao HR.

Bioorg Med Chem Lett. 2013 Feb 1;23(3):757-60. doi: 10.1016/j.bmcl.2012.11.078. Epub 2012 Dec 1.

PMID:
23265872
13.

Synthesis and anticonvulsant activity evaluation of 6-substituted-[1,2,4]triazolo[3,4-a](tetrazolo[5,1-a])phthalazine derivatives.

Bian M, Deng XQ, Gong GH, Wei CX, Quan ZS.

J Enzyme Inhib Med Chem. 2013 Aug;28(4):792-800. doi: 10.3109/14756366.2012.684052. Epub 2012 Sep 20.

PMID:
22994853
14.

Synthesis of 2-(4-substitutedmethylpiperazin-1-yl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-7-yl)acetamides and their positive inotropic evaluation.

Liu XK, Cui X, Hong L, Sun LP, Quan ZS, Piao HR.

Eur J Med Chem. 2009 Jul;44(7):3027-31. doi: 10.1016/j.ejmech.2008.08.006. Epub 2008 Aug 29.

PMID:
18824278
15.

Synthesis and inotropic evaluation of 1-substituted-N-(4,5-dihydro-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)piperidine-4-carboxamides.

Liu JY, Yu HL, Quan ZS, Cui X, Piao HR.

Bioorg Med Chem Lett. 2009 May 1;19(9):2392-5. doi: 10.1016/j.bmcl.2009.03.089. Epub 2009 Mar 26.

PMID:
19356931
16.

Synthesis and anticancer activities of novel 1,2,4-triazolo[3,4-a]phthalazine derivatives.

Xue DQ, Zhang XY, Wang CJ, Ma LY, Zhu N, He P, Shao KP, Chen PJ, Gu YF, Zhang XS, Wang CF, Ji CH, Zhang QR, Liu HM.

Eur J Med Chem. 2014 Oct 6;85:235-44. doi: 10.1016/j.ejmech.2014.07.031. Epub 2014 Jul 10.

PMID:
25086915
17.

Synthesis and anti-inflammatory activity evaluation of some novel 6-alkoxy(phenoxy)-[1,2,4]triazolo[3,4-a]phthalazine-3-amine derivatives.

Sun XY, Hu C, Deng XQ, Wei CX, Sun ZG, Quan ZS.

Eur J Med Chem. 2010 Nov;45(11):4807-12. doi: 10.1016/j.ejmech.2010.07.049. Epub 2010 Aug 6.

PMID:
20813431
18.
19.

Synthesis of 2-(4-substituted benzyl-1,4-diazepan-1-yl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-7-yl)acetamides and their positive inotropic evaluation.

Yang K, Sun LP, Liu JY, Cui X, Piao HR.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4464-7. doi: 10.1016/j.bmcl.2010.06.046. Epub 2010 Jun 15.

PMID:
20591664
20.

Synthesis and anticonvulsant activity of 6-alkoxy-[1,2,4]triazolo[3,4-a]phthalazines.

Zhang L, Guan LP, Sun XY, Wei CX, Chai KY, Quan ZS.

Chem Biol Drug Des. 2009 Mar;73(3):313-9. doi: 10.1111/j.1747-0285.2009.00776.x.

PMID:
19207467

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