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Items: 1 to 20 of 172


Probing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteria.

Deris ZZ, Swarbrick JD, Roberts KD, Azad MA, Akter J, Horne AS, Nation RL, Rogers KL, Thompson PE, Velkov T, Li J.

Bioconjug Chem. 2014 Apr 16;25(4):750-60. doi: 10.1021/bc500094d.


Cellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes.

Yun B, Azad MA, Nowell CJ, Nation RL, Thompson PE, Roberts KD, Velkov T, Li J.

Antimicrob Agents Chemother. 2015 Dec;59(12):7489-96. doi: 10.1128/AAC.01216-15.


Teaching 'old' polymyxins new tricks: new-generation lipopeptides targeting gram-negative 'superbugs'.

Velkov T, Roberts KD, Nation RL, Wang J, Thompson PE, Li J.

ACS Chem Biol. 2014 May 16;9(5):1172-7. doi: 10.1021/cb500080r.


Microbiological Assessment of Polymyxin B Components Tested Alone and in Combination.

Kassamali Z, Prince RA, Danziger LH, Rotschafer JC, Rhomberg PR, Jones RN.

Antimicrob Agents Chemother. 2015 Dec;59(12):7823-5. doi: 10.1128/AAC.01021-15.


Structure-function studies of polymyxin B nonapeptide: implications to sensitization of gram-negative bacteria.

Tsubery H, Ofek I, Cohen S, Fridkin M.

J Med Chem. 2000 Aug 10;43(16):3085-92.


Pharmacology of polymyxins: new insights into an 'old' class of antibiotics.

Velkov T, Roberts KD, Nation RL, Thompson PE, Li J.

Future Microbiol. 2013 Jun;8(6):711-24. doi: 10.2217/fmb.13.39. Review.


Battacin (Octapeptin B5), a new cyclic lipopeptide antibiotic from Paenibacillus tianmuensis active against multidrug-resistant Gram-negative bacteria.

Qian CD, Wu XC, Teng Y, Zhao WP, Li O, Fang SG, Huang ZH, Gao HC.

Antimicrob Agents Chemother. 2012 Mar;56(3):1458-65. doi: 10.1128/AAC.05580-11.


Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents.

Vaara M, Fox J, Loidl G, Siikanen O, Apajalahti J, Hansen F, Frimodt-Møller N, Nagai J, Takano M, Vaara T.

Antimicrob Agents Chemother. 2008 Sep;52(9):3229-36. doi: 10.1128/AAC.00405-08.


Mucin Binding Reduces Colistin Antimicrobial Activity.

Huang JX, Blaskovich MA, Pelingon R, Ramu S, Kavanagh A, Elliott AG, Butler MS, Montgomery AB, Cooper MA.

Antimicrob Agents Chemother. 2015 Oct;59(10):5925-31. doi: 10.1128/AAC.00808-15.


Antimicrobial effectiveness of liposomal polymyxin B against resistant Gram-negative bacterial strains.

Alipour M, Halwani M, Omri A, Suntres ZE.

Int J Pharm. 2008 May 1;355(1-2):293-8. doi: 10.1016/j.ijpharm.2007.11.035.


Susceptibility of gram-negative bacteria to polymyxin B nonapeptide.

Viljanen P, Vaara M.

Antimicrob Agents Chemother. 1984 Jun;25(6):701-5.


A novel polymyxin derivative that lacks the fatty acid tail and carries only three positive charges has strong synergism with agents excluded by the intact outer membrane.

Vaara M, Siikanen O, Apajalahti J, Fox J, Frimodt-Møller N, He H, Poudyal A, Li J, Nation RL, Vaara T.

Antimicrob Agents Chemother. 2010 Aug;54(8):3341-6. doi: 10.1128/AAC.01439-09.


In vitro evaluation of ciclopirox as an adjuvant for polymyxin B against gram-negative bacteria.

Kim KS, Kim T, Pan JG.

J Antibiot (Tokyo). 2015 Jun;68(6):395-8. doi: 10.1038/ja.2014.164. No abstract available.


Neopeptide antibiotics that function as opsonins and membrane-permeabilizing agents for gram-negative bacteria.

Tsubery H, Yaakov H, Cohen S, Giterman T, Matityahou A, Fridkin M, Ofek I.

Antimicrob Agents Chemother. 2005 Aug;49(8):3122-8.


Evaluation of colistin as an agent against multi-resistant Gram-negative bacteria.

Li J, Nation RL, Milne RW, Turnidge JD, Coulthard K.

Int J Antimicrob Agents. 2005 Jan;25(1):11-25. Review.


Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.

Gallardo-Godoy A, Muldoon C, Becker B, Elliott AG, Lash LH, Huang JX, Butler MS, Pelingon R, Kavanagh AM, Ramu S, Phetsang W, Blaskovich MA, Cooper MA.

J Med Chem. 2016 Feb 11;59(3):1068-77. doi: 10.1021/acs.jmedchem.5b01593.


Activity of polymyxin B and the novel polymyxin analogue CB-182,804 against contemporary Gram-negative pathogens in New York City.

Quale J, Shah N, Kelly P, Babu E, Backer M, Rosas-Garcia G, Salamera J, George A, Bratu S, Landman D.

Microb Drug Resist. 2012 Apr;18(2):132-6. doi: 10.1089/mdr.2011.0163.


Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two 'old' antibiotics-polymyxin B and chloramphenicol.

Abdul Rahim N, Cheah SE, Johnson MD, Yu H, Sidjabat HE, Boyce J, Butler MS, Cooper MA, Fu J, Paterson DL, Nation RL, Bergen PJ, Velkov T, Li J.

J Antimicrob Chemother. 2015 Sep;70(9):2589-97. doi: 10.1093/jac/dkv135.

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