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Items: 1 to 20 of 93

1.

Hypothalamic glucagon signals through the KATP channels to regulate glucose production.

Abraham MA, Yue JT, LaPierre MP, Rutter GA, Light PE, Filippi BM, Lam TK.

Mol Metab. 2013 Nov 28;3(2):202-8. doi: 10.1016/j.molmet.2013.11.007. eCollection 2014 Apr.

2.

Hypothalamic glucagon signaling inhibits hepatic glucose production.

Mighiu PI, Yue JT, Filippi BM, Abraham MA, Chari M, Lam CK, Yang CS, Christian NR, Charron MJ, Lam TK.

Nat Med. 2013 Jun;19(6):766-72. doi: 10.1038/nm.3115. Epub 2013 May 19.

PMID:
23685839
3.

Hypothalamic nutrient sensing activates a forebrain-hindbrain neuronal circuit to regulate glucose production in vivo.

Lam CK, Chari M, Rutter GA, Lam TK.

Diabetes. 2011 Jan;60(1):107-13. doi: 10.2337/db10-0994. Epub 2010 Sep 24.

4.
5.

Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats.

Knight CM, Gutierrez-Juarez R, Lam TK, Arrieta-Cruz I, Huang L, Schwartz G, Barzilai N, Rossetti L.

Diabetes. 2011 Nov;60(11):2691-700. doi: 10.2337/db10-0987. Epub 2011 Sep 6. Erratum in: Diabetes. 2017 Dec;66(12 ):3143-3144.

6.

Glucose regulates hypothalamic long-chain fatty acid metabolism via AMP-activated kinase (AMPK) in neurons and astrocytes.

Taïb B, Bouyakdan K, Hryhorczuk C, Rodaros D, Fulton S, Alquier T.

J Biol Chem. 2013 Dec 27;288(52):37216-29. doi: 10.1074/jbc.M113.506238. Epub 2013 Nov 15.

7.

A fatty acid-dependent hypothalamic-DVC neurocircuitry that regulates hepatic secretion of triglyceride-rich lipoproteins.

Yue JT, Abraham MA, LaPierre MP, Mighiu PI, Light PE, Filippi BM, Lam TK.

Nat Commun. 2015 Jan 12;6:5970. doi: 10.1038/ncomms6970.

PMID:
25580573
8.

Differential effects of hypothalamic long-chain fatty acid infusions on suppression of hepatic glucose production.

Ross RA, Rossetti L, Lam TK, Schwartz GJ.

Am J Physiol Endocrinol Metab. 2010 Oct;299(4):E633-9. doi: 10.1152/ajpendo.00190.2010. Epub 2010 Jul 20.

9.

Evidence for glucagon-like peptide-1 receptor signaling to activate ATP-sensitive potassium channels in pancreatic beta cells.

Kwon HJ, Park HS, Park SH, Park JH, Shin SK, Song SE, Hwang M, Cho HC, Song DK.

Biochem Biophys Res Commun. 2016 Jan 8;469(2):216-21. doi: 10.1016/j.bbrc.2015.11.127. Epub 2015 Dec 2.

PMID:
26655814
10.

Regulation of KATP channel subunit gene expression by hyperglycemia in the mediobasal hypothalamus of female rats.

Acosta-Martínez M, Levine JE.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1801-7. Epub 2007 Feb 20.

11.

Hypothalamic protein kinase C regulates glucose production.

Ross R, Wang PY, Chari M, Lam CK, Caspi L, Ono H, Muse ED, Li X, Gutierrez-Juarez R, Light PE, Schwartz GJ, Rossetti L, Lam TK.

Diabetes. 2008 Aug;57(8):2061-5. doi: 10.2337/db08-0206. Epub 2008 May 28.

12.

Hypothalamic leucine metabolism regulates liver glucose production.

Su Y, Lam TK, He W, Pocai A, Bryan J, Aguilar-Bryan L, Gutiérrez-Juárez R.

Diabetes. 2012 Jan;61(1):85-93. doi: 10.2337/db11-0857.

13.

Glucose-stimulated signaling pathways in biphasic insulin secretion.

Straub SG, Sharp GW.

Diabetes Metab Res Rev. 2002 Nov-Dec;18(6):451-63. Review.

PMID:
12469359
14.

Glucagon and lipid signaling in the hypothalamus.

LaPierre MP, Abraham MA, Filippi BM, Yue JT, Lam TK.

Mamm Genome. 2014 Oct;25(9-10):434-41. doi: 10.1007/s00335-014-9510-6. Epub 2014 Apr 10. Review.

PMID:
24718576
15.

Concerted Trafficking Regulation of Kv2.1 and KATP Channels by Leptin in Pancreatic β-Cells.

Wu Y, Shyng SL, Chen PC.

J Biol Chem. 2015 Dec 11;290(50):29676-90. doi: 10.1074/jbc.M115.670877. Epub 2015 Oct 9.

16.
17.

Hypothalamic AMP-activated protein kinase regulates glucose production.

Yang CS, Lam CK, Chari M, Cheung GW, Kokorovic A, Gao S, Leclerc I, Rutter GA, Lam TK.

Diabetes. 2010 Oct;59(10):2435-43. doi: 10.2337/db10-0221. Epub 2010 Aug 3.

18.

A role of PLC/PKC-dependent pathway in GLP-1-stimulated insulin secretion.

Shigeto M, Cha CY, Rorsman P, Kaku K.

J Mol Med (Berl). 2017 Apr;95(4):361-368. doi: 10.1007/s00109-017-1508-6. Epub 2017 Jan 17. Review.

PMID:
28097390
19.

Leptin-stimulated KATP channel trafficking: a new paradigm for β-cell stimulus-secretion coupling?

Holz GG, Chepurny OG, Leech CA.

Islets. 2013 Sep-Dec;5(5):229-32. doi: 10.4161/isl.26958. Epub 2013 Nov 8. Review.

20.

Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production.

Filippi BM, Yang CS, Tang C, Lam TK.

Cell Metab. 2012 Oct 3;16(4):500-10. doi: 10.1016/j.cmet.2012.09.005.

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