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Lipin-1 and lipin-3 together determine adiposity in vivo.

Csaki LS, Dwyer JR, Li X, Nguyen MH, Dewald J, Brindley DN, Lusis AJ, Yoshinaga Y, de Jong P, Fong L, Young SG, Reue K.

Mol Metab. 2013 Nov 28;3(2):145-54. doi: 10.1016/j.molmet.2013.11.008. eCollection 2014 Apr.


Redundant roles of the phosphatidate phosphatase family in triacylglycerol synthesis in human adipocytes.

Temprano A, Sembongi H, Han GS, Sebastián D, Capellades J, Moreno C, Guardiola J, Wabitsch M, Richart C, Yanes O, Zorzano A, Carman GM, Siniossoglou S, Miranda M.

Diabetologia. 2016 Sep;59(9):1985-94. doi: 10.1007/s00125-016-4018-0. Epub 2016 Jun 25.


Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.

Donkor J, Sariahmetoglu M, Dewald J, Brindley DN, Reue K.

J Biol Chem. 2007 Feb 9;282(6):3450-7. Epub 2006 Dec 7.


Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis.

Zhang P, Takeuchi K, Csaki LS, Reue K.

J Biol Chem. 2012 Jan 27;287(5):3485-94. doi: 10.1074/jbc.M111.296681. Epub 2011 Dec 6.


Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.

Reue K, Brindley DN.

J Lipid Res. 2008 Dec;49(12):2493-503. doi: 10.1194/jlr.R800019-JLR200. Epub 2008 Sep 12. Review.


Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.

Dwyer JR, Donkor J, Zhang P, Csaki LS, Vergnes L, Lee JM, Dewald J, Brindley DN, Atti E, Tetradis S, Yoshinaga Y, De Jong PJ, Fong LG, Young SG, Reue K.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2486-95. doi: 10.1073/pnas.1205221109. Epub 2012 Aug 20.


The role of lipin 1 in adipogenesis and lipid metabolism.

Reue K.

Novartis Found Symp. 2007;286:58-68; discussion 68-71, 162-3, 196-203.


The lipin family: mutations and metabolism.

Reue K.

Curr Opin Lipidol. 2009 Jun;20(3):165-70. doi: 10.1097/MOL.0b013e32832adee5. Review.


Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells.

Sembongi H, Miranda M, Han GS, Fakas S, Grimsey N, Vendrell J, Carman GM, Siniossoglou S.

J Biol Chem. 2013 Nov 29;288(48):34502-13. doi: 10.1074/jbc.M113.488445. Epub 2013 Oct 16.


Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.

Bou Khalil M, Blais A, Figeys D, Yao Z.

Biochim Biophys Acta. 2010 Dec;1801(12):1249-59. doi: 10.1016/j.bbalip.2010.07.008. Epub 2010 Aug 6. Review.


The lipin protein family: dual roles in lipid biosynthesis and gene expression.

Reue K, Zhang P.

FEBS Lett. 2008 Jan 9;582(1):90-6. Epub 2007 Nov 20. Review.


A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.

Donkor J, Zhang P, Wong S, O'Loughlin L, Dewald J, Kok BP, Brindley DN, Reue K.

J Biol Chem. 2009 Oct 23;284(43):29968-78. doi: 10.1074/jbc.M109.023663. Epub 2009 Aug 28.


Lipin, a lipodystrophy and obesity gene.

Phan J, Reue K.

Cell Metab. 2005 Jan;1(1):73-83.


Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling.

Csaki LS, Dwyer JR, Fong LG, Tontonoz P, Young SG, Reue K.

Prog Lipid Res. 2013 Jul;52(3):305-16. doi: 10.1016/j.plipres.2013.04.001. Epub 2013 Apr 17. Review.


Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.

Mitra MS, Chen Z, Ren H, Harris TE, Chambers KT, Hall AM, Nadra K, Klein S, Chrast R, Su X, Morris AJ, Finck BN.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):642-7. doi: 10.1073/pnas.1213493110. Epub 2012 Dec 24.


Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation.

Yao-Borengasser A, Rasouli N, Varma V, Miles LM, Phanavanh B, Starks TN, Phan J, Spencer HJ 3rd, McGehee RE Jr, Reue K, Kern PA.

Diabetes. 2006 Oct;55(10):2811-8.


The fat and thin of lipin.

Reitman ML.

Cell Metab. 2005 Jan;1(1):5-6.


Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis.

Péterfy M, Phan J, Reue K.

J Biol Chem. 2005 Sep 23;280(38):32883-9. Epub 2005 Jul 27.


Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors.

Kim HB, Kumar A, Wang L, Liu GH, Keller SR, Lawrence JC Jr, Finck BN, Harris TE.

Mol Cell Biol. 2010 Jun;30(12):3126-39. doi: 10.1128/MCB.01671-09. Epub 2010 Apr 12.

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