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Items: 1 to 20 of 100

1.

The GABA synapse as a target for antiepileptic drugs: a historical overview focused on GABA transporters.

Schousboe A, Madsen KK, Barker-Haliski ML, White HS.

Neurochem Res. 2014 Oct;39(10):1980-7. doi: 10.1007/s11064-014-1263-9. Epub 2014 Mar 14. Review.

PMID:
24627365
2.

GABA transporters and GABA-transaminase as drug targets.

Sarup A, Larsson OM, Schousboe A.

Curr Drug Targets CNS Neurol Disord. 2003 Aug;2(4):269-77. Review.

PMID:
12871037
3.

Neuronal and non-neuronal GABA transporters as targets for antiepileptic drugs.

Madsen KK, White HS, Schousboe A.

Pharmacol Ther. 2010 Mar;125(3):394-401. doi: 10.1016/j.pharmthera.2009.11.007. Epub 2009 Dec 22. Review.

PMID:
20026354
4.

The four human gamma-aminobutyric acid (GABA) transporters: pharmacological characterization and validation of a highly efficient screening assay.

Kvist T, Christiansen B, Jensen AA, Bräuner-Osborne H.

Comb Chem High Throughput Screen. 2009 Mar;12(3):241-9.

PMID:
19275529
5.

Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1.

Dalby NO, Thomsen C, Fink-Jensen A, Lundbeck J, Søkilde B, Man CM, Sørensen PO, Meldrum B.

Epilepsy Res. 1997 Jul;28(1):51-61.

PMID:
9255599
6.

Discovery of a subtype selective inhibitor of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile.

Kragholm B, Kvist T, Madsen KK, Jørgensen L, Vogensen SB, Schousboe A, Clausen RP, Jensen AA, Bräuner-Osborne H.

Biochem Pharmacol. 2013 Aug 15;86(4):521-8. doi: 10.1016/j.bcp.2013.06.007. Epub 2013 Jun 19.

PMID:
23792119
7.

Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkylated analogs.

White HS, Sarup A, Bolvig T, Kristensen AS, Petersen G, Nelson N, Pickering DS, Larsson OM, Frølund B, Krogsgaard-Larsen P, Schousboe A.

J Pharmacol Exp Ther. 2002 Aug;302(2):636-44.

9.

Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.

Borden LA, Murali Dhar TG, Smith KE, Weinshank RL, Branchek TA, Gluchowski C.

Eur J Pharmacol. 1994 Oct 14;269(2):219-24.

PMID:
7851497
10.

A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus.

Kersanté F, Rowley SC, Pavlov I, Gutièrrez-Mecinas M, Semyanov A, Reul JM, Walker MC, Linthorst AC.

J Physiol. 2013 May 15;591(10):2429-41. doi: 10.1113/jphysiol.2012.246298. Epub 2013 Feb 4.

11.
12.
13.

Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes.

Vaz SH, Jørgensen TN, Cristóvão-Ferreira S, Duflot S, Ribeiro JA, Gether U, Sebastião AM.

J Biol Chem. 2011 Nov 25;286(47):40464-76. doi: 10.1074/jbc.M111.232009. Epub 2011 Oct 3.

14.

Up-regulation of GABA transporters and GABA(A) receptor α1 subunit in tremor rat hippocampus.

Mao X, Guo F, Yu J, Min D, Wang Z, Xie N, Chen T, Shaw C, Cai J.

Neurosci Lett. 2010 Dec 17;486(3):150-5. doi: 10.1016/j.neulet.2010.09.033. Epub 2010 Sep 17.

PMID:
20851161
15.

GABA transporters as drug targets for modulation of GABAergic activity.

Schousboe A, Sarup A, Larsson OM, White HS.

Biochem Pharmacol. 2004 Oct 15;68(8):1557-63.

PMID:
15451399
16.

Characteristic development of the GABA-removal system in the mouse spinal cord.

Kim J, Kosaka Y, Shimizu-Okabe C, Niizaki A, Takayama C.

Neuroscience. 2014 Mar 14;262:129-42. doi: 10.1016/j.neuroscience.2013.12.066. Epub 2014 Jan 9.

PMID:
24412234
17.
18.

Impairment of GABA transporter GAT-1 terminates cortical recurrent network activity via enhanced phasic inhibition.

Razik DS, Hawellek DJ, Antkowiak B, Hentschke H.

Front Neural Circuits. 2013 Sep 11;7:141. doi: 10.3389/fncir.2013.00141. eCollection 2013.

19.

High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach.

Schlessinger A, Wittwer MB, Dahlin A, Khuri N, Bonomi M, Fan H, Giacomini KM, Sali A.

J Biol Chem. 2012 Nov 2;287(45):37745-56. doi: 10.1074/jbc.M112.388157. Epub 2012 Aug 29.

20.

Application of MS Transport Assays to the Four Human γ-Aminobutyric Acid Transporters.

Schmitt S, Höfner G, Wanner KT.

ChemMedChem. 2015 Sep;10(9):1498-510. doi: 10.1002/cmdc.201500254. Epub 2015 Jul 27.

PMID:
26220444

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