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PTTG1 inhibits SMAD3 in prostate cancer cells to promote their proliferation.

Huang S, Liao Q, Li L, Xin D.

Tumour Biol. 2014 Jul;35(7):6265-70. doi: 10.1007/s13277-014-1818-z. Epub 2014 Mar 14.


Pttg1 inhibits TGFβ signaling in breast cancer cells to promote their growth.

Zhang G, Zhao Q, Yu S, Lin R, Yi X.

Tumour Biol. 2015 Jan;36(1):199-203. doi: 10.1007/s13277-014-2609-2. Epub 2014 Sep 17. Retraction in: Tumour Biol. 2017 Apr 20;:.


RNAi-mediated knockdown of pituitary tumor- transforming gene-1 (PTTG1) suppresses the proliferation and invasive potential of PC3 human prostate cancer cells.

Huang SQ, Liao QJ, Wang XW, Xin DQ, Chen SX, Wu QJ, Ye G.

Braz J Med Biol Res. 2012 Nov;45(11):995-1001. Epub 2012 Aug 9.


Knockdown of PTTG1 inhibits the growth and invasion of lung adenocarcinoma cells through regulation of TGFB1/SMAD3 signaling.

Li WH, Chang L, Xia YX, Wang L, Liu YY, Wang YH, Jiang Z, Xiao J, Wang ZR.

Int J Immunopathol Pharmacol. 2015 Mar;28(1):45-52. doi: 10.1177/0306419015572073.


Interleukin-6/signal transducer and activator of transcription 3 promotes prostate cancer resistance to androgen deprivation therapy via regulating pituitary tumor transforming gene 1 expression.

Huang S, Liu Q, Liao Q, Wu Q, Sun B, Yang Z, Hu X, Tan M, Li L.

Cancer Sci. 2018 Mar;109(3):678-687. doi: 10.1111/cas.13493. Epub 2018 Feb 20.


PTTG1, A novel androgen responsive gene is required for androgen-induced prostate cancer cell growth and invasion.

Zhang Z, Jin B, Jin Y, Huang S, Niu X, Mao Z, Xin D.

Exp Cell Res. 2017 Jan 1;350(1):1-8. doi: 10.1016/j.yexcr.2016.10.013. Epub 2016 Oct 15.


Prostate cancer cell response to paclitaxel is affected by abnormally expressed securin PTTG1.

Castilla C, Flores ML, Medina R, Pérez-Valderrama B, Romero F, Tortolero M, Japón MA, Sáez C.

Mol Cancer Ther. 2014 Oct;13(10):2372-83. doi: 10.1158/1535-7163.MCT-13-0405. Epub 2014 Aug 13.


Deregulated E2F5/p38/SMAD3 Circuitry Reinforces the Pro-Tumorigenic Switch of TGFβ Signaling in Prostate Cancer.

Majumder S, Bhowal A, Basu S, Mukherjee P, Chatterji U, Sengupta S.

J Cell Physiol. 2016 Nov;231(11):2482-92. doi: 10.1002/jcp.25361. Epub 2016 Mar 14.


Targeting SMAD3 for inhibiting prostate cancer metastasis.

Xia Q, Li C, Bian P, Wang J, Dong S.

Tumour Biol. 2014 Sep;35(9):8537-41. doi: 10.1007/s13277-014-2368-0. Epub 2014 Jul 24.


Differential role of Sloan-Kettering Institute (Ski) protein in Nodal and transforming growth factor-beta (TGF-β)-induced Smad signaling in prostate cancer cells.

Vo BT, Cody B, Cao Y, Khan SA.

Carcinogenesis. 2012 Nov;33(11):2054-64. doi: 10.1093/carcin/bgs252. Epub 2012 Jul 27.


PTTG1 expression is associated with hyperproliferative disease and poor prognosis in multiple myeloma.

Noll JE, Vandyke K, Hewett DR, Mrozik KM, Bala RJ, Williams SA, Kok CH, Zannettino AC.

J Hematol Oncol. 2015 Oct 6;8:106. doi: 10.1186/s13045-015-0209-2.


[Regulation of expression of pituitary tumor transforming gene 1 (PTTG1) by androgen in prostate cancer].

Xin DQ, Zhu XH, Lai YQ, You R, Na YQ, Guo YL, Mao ZB.

Beijing Da Xue Xue Bao Yi Xue Ban. 2005 Dec 18;37(6):638-40. Chinese.


The PTTG1-targeting miRNAs miR-329, miR-300, miR-381, and miR-655 inhibit pituitary tumor cell tumorigenesis and are involved in a p53/PTTG1 regulation feedback loop.

Liang HQ, Wang RJ, Diao CF, Li JW, Su JL, Zhang S.

Oncotarget. 2015 Oct 6;6(30):29413-27. doi: 10.18632/oncotarget.5003.


Pttg1 Promotes Growth of Breast Cancer through P27 Nuclear Exclusion.

Xiea Y, Wangb R.

Cell Physiol Biochem. 2016;38(1):393-400. doi: 10.1159/000438660. Epub 2016 Jan 29.


Down-regulation of the oncogene PTTG1 via the KLF6 tumor suppressor during induction of myeloid differentiation.

Chen PY, Yen JH, Kao RH, Chen JH.

PLoS One. 2013 Aug 16;8(8):e71282. doi: 10.1371/journal.pone.0071282. eCollection 2013.


PTTG1 Levels Are Predictive of Saracatinib Sensitivity in Ovarian Cancer Cell Lines.

Nakachi I, Helfrich BA, Spillman MA, Mickler EA, Olson CJ, Rice JL, Coldren CD, Heasley LE, Geraci MW, Stearman RS.

Clin Transl Sci. 2016 Dec;9(6):293-301. doi: 10.1111/cts.12413. Epub 2016 Oct 20.


Alteration of Pituitary Tumor Transforming Gene-1 Regulates Trophoblast Invasion via the Integrin/Rho-Family Signaling Pathway.

Lim SM, Jang HY, Lee JE, Shin JS, Park SH, Yoon BH, Kim GJ.

PLoS One. 2016 Feb 22;11(2):e0149371. doi: 10.1371/journal.pone.0149371. eCollection 2016.


Genomic instability and proliferation/survival pathways in RB1-deficient malignancies.

Pappas L, Xu XL, Abramson DH, Jhanwar SC.

Adv Biol Regul. 2017 May;64:20-32. doi: 10.1016/j.jbior.2017.01.002. Epub 2017 Feb 8.


TGFβ/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells.

Bailey KL, Agarwal E, Chowdhury S, Luo J, Brattain MG, Black JD, Wang J.

PLoS One. 2017 Apr 17;12(4):e0176096. doi: 10.1371/journal.pone.0176096. eCollection 2017.


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