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Items: 1 to 20 of 163

1.

Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity.

O'Donnell KC, Lulla A, Stahl MC, Wheat ND, Bronstein JM, Sagasti A.

Dis Model Mech. 2014 May;7(5):571-82. doi: 10.1242/dmm.013185. Epub 2014 Mar 13.

2.

WldS and PGC-1α regulate mitochondrial transport and oxidation state after axonal injury.

O'Donnell KC, Vargas ME, Sagasti A.

J Neurosci. 2013 Sep 11;33(37):14778-90. doi: 10.1523/JNEUROSCI.1331-13.2013.

3.

Peripheral glia have a pivotal role in the initial response to axon degeneration of peripheral sensory neurons in zebrafish.

Pope HM, Voigt MM.

PLoS One. 2014 Jul 24;9(7):e103283. doi: 10.1371/journal.pone.0103283. eCollection 2014.

4.

Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types.

Villegas R, Martin SM, O'Donnell KC, Carrillo SA, Sagasti A, Allende ML.

Neural Dev. 2012 Jun 8;7:19. doi: 10.1186/1749-8104-7-19.

5.

Live Imaging of Calcium Dynamics during Axon Degeneration Reveals Two Functionally Distinct Phases of Calcium Influx.

Vargas ME, Yamagishi Y, Tessier-Lavigne M, Sagasti A.

J Neurosci. 2015 Nov 11;35(45):15026-38. doi: 10.1523/JNEUROSCI.2484-15.2015.

6.

PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein.

Ciron C, Zheng L, Bobela W, Knott GW, Leone TC, Kelly DP, Schneider BL.

Acta Neuropathol Commun. 2015 Apr 1;3:16. doi: 10.1186/s40478-015-0200-8.

7.

Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning.

Martin SM, O'Brien GS, Portera-Cailliau C, Sagasti A.

Development. 2010 Dec;137(23):3985-94. doi: 10.1242/dev.053611. Epub 2010 Nov 1.

8.

Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain.

Siebert H, Kahle PJ, Kramer ML, Isik T, Schlüter OM, Schulz-Schaeffer WJ, Brück W.

J Neurochem. 2010 Aug;114(4):1007-18. doi: 10.1111/j.1471-4159.2010.06832.x. Epub 2010 May 26.

9.

Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLD(S)-mediated axon protection independent of axonal mitochondria.

Kitay BM, McCormack R, Wang Y, Tsoulfas P, Zhai RG.

Hum Mol Genet. 2013 Apr 15;22(8):1601-14. doi: 10.1093/hmg/ddt009. Epub 2013 Jan 11.

10.

Mechanisms of axonal spheroid formation in central nervous system Wallerian degeneration.

Beirowski B, Nógrádi A, Babetto E, Garcia-Alias G, Coleman MP.

J Neuropathol Exp Neurol. 2010 May;69(5):455-72. doi: 10.1097/NEN.0b013e3181da84db.

PMID:
20418780
11.

Protective role of olesoxime against wild-type α-synuclein-induced toxicity in human neuronally differentiated SHSY-5Y cells.

Gouarné C, Tracz J, Paoli MG, Deluca V, Seimandi M, Tardif G, Xilouri M, Stefanis L, Bordet T, Pruss RM.

Br J Pharmacol. 2015 Jan;172(1):235-45. doi: 10.1111/bph.12939. Epub 2014 Dec 1.

12.

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

Martin LJ, Pan Y, Price AC, Sterling W, Copeland NG, Jenkins NA, Price DL, Lee MK.

J Neurosci. 2006 Jan 4;26(1):41-50.

13.

Axon degeneration in Parkinson's disease.

Burke RE, O'Malley K.

Exp Neurol. 2013 Aug;246:72-83. doi: 10.1016/j.expneurol.2012.01.011. Epub 2012 Jan 18. Review.

14.

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.

Rockenstein E, Nuber S, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Trejo-Morales M, Gerez J, Picotti P, Jensen PH, Campioni S, Riek R, Winkler J, Gage FH, Winner B, Masliah E.

Brain. 2014 May;137(Pt 5):1496-513. doi: 10.1093/brain/awu057. Epub 2014 Mar 24.

15.

[Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies].

Orimo S.

Rinsho Shinkeigaku. 2008 Jan;48(1):11-24. Review. Japanese.

PMID:
18386627
16.

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy.

Xilouri M, Vogiatzi T, Vekrellis K, Park D, Stefanis L.

PLoS One. 2009;4(5):e5515. doi: 10.1371/journal.pone.0005515. Epub 2009 May 13.

17.

The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves.

Beirowski B, Adalbert R, Wagner D, Grumme DS, Addicks K, Ribchester RR, Coleman MP.

BMC Neurosci. 2005 Feb 1;6:6.

18.

Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein.

Subramaniam SR, Vergnes L, Franich NR, Reue K, Chesselet MF.

Neurobiol Dis. 2014 Oct;70:204-13. doi: 10.1016/j.nbd.2014.06.017. Epub 2014 Jul 10.

19.

The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice.

Mi W, Beirowski B, Gillingwater TH, Adalbert R, Wagner D, Grumme D, Osaka H, Conforti L, Arnhold S, Addicks K, Wada K, Ribchester RR, Coleman MP.

Brain. 2005 Feb;128(Pt 2):405-16. Epub 2005 Jan 11.

PMID:
15644421
20.

Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.

Schildknecht S, Gerding HR, Karreman C, Drescher M, Lashuel HA, Outeiro TF, Di Monte DA, Leist M.

J Neurochem. 2013 May;125(4):491-511. doi: 10.1111/jnc.12226. Epub 2013 Mar 19. Review.

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