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Factors associated with D-dimer levels in HIV-infected individuals.

Borges AH, O'Connor JL, Phillips AN, Baker JV, Vjecha MJ, Losso MH, Klinker H, Lopardo G, Williams I, Lundgren JD; INSIGHT SMART Study Group; ESPRIT Study Group; SILCAAT Scientific Committee.

PLoS One. 2014 Mar 13;9(3):e90978. doi: 10.1371/journal.pone.0090978. eCollection 2014.


Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death.

Boulware DR, Hullsiek KH, Puronen CE, Rupert A, Baker JV, French MA, Bohjanen PR, Novak RM, Neaton JD, Sereti I; INSIGHT Study Group.

J Infect Dis. 2011 Jun 1;203(11):1637-46. doi: 10.1093/infdis/jir134.


Interleukin-2 cycling causes transient increases in high-sensitivity C-reactive protein and D-dimer that are not associated with plasma HIV-RNA levels.

Porter BO, Shen J, Kovacs JA, Davey RT, Rehm C, Lozier J, Csako G, Nghiem K, Costello R, Lane HC, Sereti I.

AIDS. 2009 Sep 24;23(15):2015-9. doi: 10.1097/QAD.0b013e32832d72c6.


Factors Associated With Plasma IL-6 Levels During HIV Infection.

Borges ÁH, O'Connor JL, Phillips AN, Rönsholt FF, Pett S, Vjecha MJ, French MA, Lundgren JD; INSIGHT SMART and ESPRIT Study Groups and the SILCAAT Scientific Committee.

J Infect Dis. 2015 Aug 15;212(4):585-95. doi: 10.1093/infdis/jiv123. Epub 2015 Feb 26.


Inflammatory and coagulation biomarkers and mortality in patients with HIV infection.

Kuller LH, Tracy R, Belloso W, De Wit S, Drummond F, Lane HC, Ledergerber B, Lundgren J, Neuhaus J, Nixon D, Paton NI, Neaton JD; INSIGHT SMART Study Group.

PLoS Med. 2008 Oct 21;5(10):e203. doi: 10.1371/journal.pmed.0050203.


Elevated D-dimer is independently associated with endothelial dysfunction: a cross-sectional study in HIV-infected adults on antiretroviral therapy.

Hileman CO, Longenecker CT, Carman TL, Milne GL, Labbato DE, Storer NJ, White CA, McComsey GA.

Antivir Ther. 2012;17(7):1345-9. doi: 10.3851/IMP2297. Epub 2012 Aug 9.


Interleukin-6 and D-dimer levels at seroconversion as predictors of HIV-1 disease progression.

Hamlyn E, Fidler S, Stöhr W, Cooper DA, Tambussi G, Schechter M, Miro JM, Mcclure M, Weber J, Babiker A, Porter K; SPARTAC Trial Investigators.

AIDS. 2014 Mar 27;28(6):869-74. doi: 10.1097/QAD.0000000000000155.


Changes in inflammatory and coagulation biomarkers: a randomized comparison of immediate versus deferred antiretroviral therapy in patients with HIV infection.

Baker JV, Neuhaus J, Duprez D, Kuller LH, Tracy R, Belloso WH, De Wit S, Drummond F, Lane HC, Ledergerber B, Lundgren J, Nixon DE, Paton NI, Neaton JD; INSIGHT SMART Study Group.

J Acquir Immune Defic Syndr. 2011 Jan 1;56(1):36-43. doi: 10.1097/QAI.0b013e3181f7f61a.


Markers of inflammation and activation of coagulation are associated with anaemia in antiretroviral-treated HIV disease.

Borges ÁH, Weitz JI, Collins G, Baker JV, Lévy Y, Davey RT Jr, Phillips AN, Neaton JD, Lundgren JD, Deeks SG; INSIGHT SILCAAT Scientific Committee.

AIDS. 2014 Jul 31;28(12):1791-6. doi: 10.1097/QAD.0000000000000344.


Predicting risk of cancer during HIV infection: the role of inflammatory and coagulation biomarkers.

Borges ÁH, Silverberg MJ, Wentworth D, Grulich AE, Fätkenheuer G, Mitsuyasu R, Tambussi G, Sabin CA, Neaton JD, Lundgren JD; INSIGHT SMART; ESPRIT; SILCAAT Study Groups.

AIDS. 2013 Jun 1;27(9):1433-41. doi: 10.1097/QAD.0b013e32835f6b0c.


Elevations in D-dimer and C-reactive protein are associated with the development of osteonecrosis of the hip in HIV-infected adults.

Morse CG, Dodd LE, Nghiem K, Costello R, Csako G, Lane HC, Lozier JN, Kovacs JA.

AIDS. 2013 Feb 20;27(4):591-5. doi: 10.1097/QAD.0b013e32835c206a.


Pre-therapy inflammation and coagulation activation and long-term CD4 count responses to the initiation of antiretroviral therapy.

Achhra AC, Phillips A, Emery S, MacArthur RD, Furrer H, De Wit S, Losso M, Law MG; International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) Strategic Management of Antiretroviral Therapy (SMART) and Flexible Initial Retrovirus Suppressive Therapies (FIRST) study groups.

HIV Med. 2015 Aug;16(7):449-54. doi: 10.1111/hiv.12258. Epub 2015 May 11.


Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy.

Grund B, Baker JV, Deeks SG, Wolfson J, Wentworth D, Cozzi-Lepri A, Cohen CJ, Phillips A, Lundgren JD, Neaton JD; INSIGHT SMART/ESPRIT/SILCAAT Study Group.

PLoS One. 2016 May 12;11(5):e0155100. doi: 10.1371/journal.pone.0155100. eCollection 2016.


D-Dimer Levels before HIV Seroconversion Remain Elevated Even after Viral Suppression and Are Associated with an Increased Risk of Non-AIDS Events.

Freiberg MS, Bebu I, Tracy R, So-Armah K, Okulicz J, Ganesan A, Armstrong A, O'Bryan T, Rimland D, Justice AC, Agan BK; Infectious Disease Clinical Research Program HIV Working Group.

PLoS One. 2016 Apr 18;11(4):e0152588. doi: 10.1371/journal.pone.0152588. eCollection 2016.


Evaluation of cardiovascular biomarkers in a randomized trial of fosamprenavir/ritonavir vs. efavirenz with abacavir/lamivudine in underrepresented, antiretroviral-naïve, HIV-infected patients (SUPPORT): 96-week results.

Kumar P, DeJesus E, Huhn G, Sloan L, Small CB, Edelstein H, Felizarta F, Hao R, Ross L, Stancil B, Pappa K, Ha B; SUPPORT Study Team.

BMC Infect Dis. 2013 Jun 7;13:269. doi: 10.1186/1471-2334-13-269.


Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection.

Neuhaus J, Jacobs DR Jr, Baker JV, Calmy A, Duprez D, La Rosa A, Kuller LH, Pett SL, Ristola M, Ross MJ, Shlipak MG, Tracy R, Neaton JD.

J Infect Dis. 2010 Jun 15;201(12):1788-95. doi: 10.1086/652749.


Biomarkers of inflammation, coagulation and microbial translocation in HIV/HCV co-infected patients in the SMART study.

Peters L, Neuhaus J, Duprez D, Neaton JD, Tracy R, Klein MB, Mocroft A, Rockstroh J, Dore G, Lundgren JD; INSIGHT SMART Study Group.

J Clin Virol. 2014 Jul;60(3):295-300. doi: 10.1016/j.jcv.2014.03.017. Epub 2014 Apr 8.


Biomarkers and bacterial pneumonia risk in patients with treated HIV infection: a case-control study.

Bjerk SM, Baker JV, Emery S, Neuhaus J, Angus B, Gordin FM, Pett SL, Stephan C, Kunisaki KM; INSIGHT SMART Study Group.

PLoS One. 2013;8(2):e56249. doi: 10.1371/journal.pone.0056249. Epub 2013 Feb 15.


d-Dimer and CRP levels are elevated prior to antiretroviral treatment in patients who develop IRIS.

Porter BO, Ouedraogo GL, Hodge JN, Smith MA, Pau A, Roby G, Kwan R, Bishop RJ, Rehm C, Mican J, Sereti I.

Clin Immunol. 2010 Jul;136(1):42-50. doi: 10.1016/j.clim.2010.02.010. Epub 2010 Mar 15. Erratum in: Clin Immunol. 2010 Sep;136(3):462.


Pre-ART levels of inflammation and coagulation markers are strong predictors of death in a South African cohort with advanced HIV disease.

Ledwaba L, Tavel JA, Khabo P, Maja P, Qin J, Sangweni P, Liu X, Follmann D, Metcalf JA, Orsega S, Baseler B, Neaton JD, Lane HC; Project Phidisa Biomarkers Team.

PLoS One. 2012;7(3):e24243. doi: 10.1371/journal.pone.0024243. Epub 2012 Mar 20.

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