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Items: 1 to 20 of 293


SMAD4 loss triggers the phenotypic changes of pancreatic ductal adenocarcinoma cells.

Chen YW, Hsiao PJ, Weng CC, Kuo KK, Kuo TL, Wu DC, Hung WC, Cheng KH.

BMC Cancer. 2014 Mar 14;14:181. doi: 10.1186/1471-2407-14-181.


Stem cell marker nestin is critical for TGF-β1-mediated tumor progression in pancreatic cancer.

Su HT, Weng CC, Hsiao PJ, Chen LH, Kuo TL, Chen YW, Kuo KK, Cheng KH.

Mol Cancer Res. 2013 Jul;11(7):768-79. doi: 10.1158/1541-7786.MCR-12-0511. Epub 2013 Apr 3.


Down-regulation of microRNA-494 via loss of SMAD4 increases FOXM1 and β-catenin signaling in pancreatic ductal adenocarcinoma cells.

Li L, Li Z, Kong X, Xie D, Jia Z, Jiang W, Cui J, Du Y, Wei D, Huang S, Xie K.

Gastroenterology. 2014 Aug;147(2):485-97.e18. doi: 10.1053/j.gastro.2014.04.048. Epub 2014 May 20.


MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation of SMAD4.

Xia X, Zhang K, Cen G, Jiang T, Cao J, Huang K, Huang C, Zhao Q, Qiu Z.

Oncotarget. 2015 Aug 28;6(25):21046-63.


Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.

Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA.

Genes Dev. 2006 Nov 15;20(22):3130-46.


Insights Into SMAD4 Loss in Pancreatic Cancer From Inducible Restoration of TGF-β Signaling.

Fullerton PT Jr, Creighton CJ, Matzuk MM.

Mol Endocrinol. 2015 Oct;29(10):1440-53. doi: 10.1210/me.2015-1102. Epub 2015 Aug 18.


Yes-associated protein (YAP65) in relation to Smad7 expression in human pancreatic ductal adenocarcinoma.

Guo J, Kleeff J, Zhao Y, Li J, Giese T, Esposito I, Büchler MW, Korc M, Friess H.

Int J Mol Med. 2006 May;17(5):761-7.


Cotargeting of epidermal growth factor receptor and PI3K overcomes PI3K-Akt oncogenic dependence in pancreatic ductal adenocarcinoma.

Wong MH, Xue A, Julovi SM, Pavlakis N, Samra JS, Hugh TJ, Gill AJ, Peters L, Baxter RC, Smith RC.

Clin Cancer Res. 2014 Aug 1;20(15):4047-58. doi: 10.1158/1078-0432.CCR-13-3377. Epub 2014 Jun 3.


Clinical, molecular and genetic validation of a murine orthotopic xenograft model of pancreatic adenocarcinoma using fresh human specimens.

Walters DM, Stokes JB, Adair SJ, Stelow EB, Borgman CA, Lowrey BT, Xin W, Blais EM, Lee JK, Papin JA, Parsons JT, Bauer TW.

PLoS One. 2013 Oct 18;8(10):e77065. doi: 10.1371/journal.pone.0077065. eCollection 2013.


Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells.

Zhao S, Ammanamanchi S, Brattain M, Cao L, Thangasamy A, Wang J, Freeman JW.

J Biol Chem. 2008 Apr 25;283(17):11293-301. doi: 10.1074/jbc.M800154200. Epub 2008 Feb 29.


Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling.

Ungefroren H, Sebens S, Giehl K, Helm O, Groth S, Fändrich F, Röcken C, Sipos B, Lehnert H, Gieseler F.

Oncotarget. 2014 Jan 15;5(1):277-90.


Loss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis.

Leung L, Radulovich N, Zhu CQ, Wang D, To C, Ibrahimov E, Tsao MS.

PLoS One. 2013 Dec 27;8(12):e84366. doi: 10.1371/journal.pone.0084366. eCollection 2013.


Biomarkers of TGF-β signaling pathway and prognosis of pancreatic cancer.

Javle M, Li Y, Tan D, Dong X, Chang P, Kar S, Li D.

PLoS One. 2014 Jan 20;9(1):e85942. doi: 10.1371/journal.pone.0085942. eCollection 2014.


Kindlin-2 induced by TGF-β signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9.

Zhan J, Song J, Wang P, Chi X, Wang Y, Guo Y, Fang W, Zhang H.

Cancer Lett. 2015 May 28;361(1):75-85. doi: 10.1016/j.canlet.2015.02.039. Epub 2015 Feb 24.


Monocarboxylate Transporters MCT1 and MCT4 Regulate Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells.

Kong SC, Nøhr-Nielsen A, Zeeberg K, Reshkin SJ, Hoffmann EK, Novak I, Pedersen SF.

Pancreas. 2016 Aug;45(7):1036-47. doi: 10.1097/MPA.0000000000000571.


The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling.

Tactacan CM, Phua YW, Liu L, Zhang L, Humphrey ES, Cowley M, Pinese M, Biankin AV, Daly RJ.

Mol Cancer. 2015 Jul 29;14:139. doi: 10.1186/s12943-015-0412-3.


Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-κB Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells.

Bera A, Zhao S, Cao L, Chiao PJ, Freeman JW.

PLoS One. 2013 Dec 5;8(12):e82282. doi: 10.1371/journal.pone.0082282. eCollection 2013.


MicroRNA-21 in pancreatic ductal adenocarcinoma tumor-associated fibroblasts promotes metastasis.

Kadera BE, Li L, Toste PA, Wu N, Adams C, Dawson DW, Donahue TR.

PLoS One. 2013 Aug 22;8(8):e71978. doi: 10.1371/journal.pone.0071978. eCollection 2013.


Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice.

Xu X, Ehdaie B, Ohara N, Yoshino T, Deng CX.

Oncogene. 2010 Feb 4;29(5):674-86. doi: 10.1038/onc.2009.375. Epub 2009 Nov 9.


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