Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 79

1.

Structure-activity relationships for withanolides as inducers of the cellular heat-shock response.

Wijeratne EM, Xu YM, Scherz-Shouval R, Marron MT, Rocha DD, Liu MX, Costa-Lotufo LV, Santagata S, Lindquist S, Whitesell L, Gunatilaka AA.

J Med Chem. 2014 Apr 10;57(7):2851-63. doi: 10.1021/jm401279n. Epub 2014 Mar 25.

PMID:
24625088
2.

Epoxide group relationship with cytotoxicity in withanolide derivatives from Withania somnifera.

Joshi P, Misra L, Siddique AA, Srivastava M, Kumar S, Darokar MP.

Steroids. 2014 Jan;79:19-27. doi: 10.1016/j.steroids.2013.10.008. Epub 2013 Nov 1.

PMID:
24184562
3.

Withaferin A and Withanolide D Analogues with Dual Heat-Shock-Inducing and Cytotoxic Activities: Semisynthesis and Biological Evaluation.

Wijeratne EMK, Oliveira MCF, Mafezoli J, Xu YM, Minguzzi S, Batista PHJ, Pessoa ODL, Whitesell L, Gunatilaka AAL.

J Nat Prod. 2018 Apr 27;81(4):825-837. doi: 10.1021/acs.jnatprod.7b00918. Epub 2018 Mar 14.

PMID:
29537263
4.

Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells.

Llanos GG, Araujo LM, Jiménez IA, Moujir LM, Bazzocchi IL.

Eur J Med Chem. 2012 Aug;54:499-511. doi: 10.1016/j.ejmech.2012.05.032. Epub 2012 Jun 1.

PMID:
22705001
5.

A novel combination of withaferin A and sorafenib shows synergistic efficacy against both papillary and anaplastic thyroid cancers.

Cohen SM, Mukerji R, Timmermann BN, Samadi AK, Cohen MS.

Am J Surg. 2012 Dec;204(6):895-900; discussion 900-1. doi: 10.1016/j.amjsurg.2012.07.027.

PMID:
23231932
6.

17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure-Activity Relationships.

Xu YM, Brooks AD, Wijeratne EM, Henrich CJ, Tewary P, Sayers TJ, Gunatilaka AA.

J Med Chem. 2017 Apr 13;60(7):3039-3051. doi: 10.1021/acs.jmedchem.7b00069. Epub 2017 Mar 21.

PMID:
28257574
7.

Antiproliferative and quinone reductase-inducing activities of withanolides derivatives.

García ME, Nicotra VE, Oberti JC, Ríos-Luci C, León LG, Marler L, Li G, Pezzuto JM, van Breemen RB, Padrón JM, Hueso-Falcón I, Estévez-Braun A.

Eur J Med Chem. 2014 Jul 23;82:68-81. doi: 10.1016/j.ejmech.2014.05.045. Epub 2014 May 20.

PMID:
24878636
8.

Anti-cancer activity of withaferin A in B-cell lymphoma.

McKenna MK, Gachuki BW, Alhakeem SS, Oben KN, Rangnekar VM, Gupta RC, Bondada S.

Cancer Biol Ther. 2015;16(7):1088-98. doi: 10.1080/15384047.2015.1046651.

9.
10.

Structure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells.

Gu M, Yu Y, Gunaherath GM, Gunatilaka AA, Li D, Sun D.

Invest New Drugs. 2014 Feb;32(1):68-74. doi: 10.1007/s10637-013-9987-y. Epub 2013 Jul 26.

11.

Structure-based design, synthesis, and biological evaluation of withaferin A-analogues as potent apoptotic inducers.

Llanos GG, Araujo LM, Jiménez IA, Moujir LM, Rodríguez J, Jiménez C, Bazzocchi IL.

Eur J Med Chem. 2017 Nov 10;140:52-64. doi: 10.1016/j.ejmech.2017.09.004. Epub 2017 Sep 6.

PMID:
28923386
12.

Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences.

Vaishnavi K, Saxena N, Shah N, Singh R, Manjunath K, Uthayakumar M, Kanaujia SP, Kaul SC, Sekar K, Wadhwa R.

PLoS One. 2012;7(9):e44419. doi: 10.1371/journal.pone.0044419. Epub 2012 Sep 4.

13.

Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways.

Grogan PT, Sleder KD, Samadi AK, Zhang H, Timmermann BN, Cohen MS.

Invest New Drugs. 2013 Jun;31(3):545-57. doi: 10.1007/s10637-012-9888-5. Epub 2012 Nov 6.

14.

Molecular insight in the multifunctional activities of Withaferin A.

Vanden Berghe W, Sabbe L, Kaileh M, Haegeman G, Heyninck K.

Biochem Pharmacol. 2012 Nov 15;84(10):1282-91. doi: 10.1016/j.bcp.2012.08.027. Epub 2012 Sep 6. Review.

PMID:
22981382
15.

Withanolides from Withania aristata and their cytotoxic activity.

Llanos GG, Araujo LM, Jiménez IA, Moujir LM, Vázquez JT, Bazzocchi IL.

Steroids. 2010 Dec;75(12):974-81. doi: 10.1016/j.steroids.2010.06.001. Epub 2010 Jun 11.

PMID:
20542049
16.

An analog of withaferin A activates the MAPK and glutathione "stress" pathways and inhibits pancreatic cancer cell proliferation.

Liu X, Qi W, Cooke LS, Kithsiri Wijeratne EM, Xu YM, Marron MT, Leslie Gunatilaka AA, Mahadevan D.

Cancer Invest. 2011 Dec;29(10):668-75. doi: 10.3109/07357907.2011.626478.

PMID:
22085270
17.

Withanolide Z, a new chlorinated withanolide from Withania somnifera.

Pramanick S, Roy A, Ghosh S, Majumder HK, Mukhopadhyay S.

Planta Med. 2008 Nov;74(14):1745-8. doi: 10.1055/s-2008-1081357. Epub 2008 Nov 5.

PMID:
18988152
18.

Antiproliferative effects of withanolides from Withania adpressa.

Abdeljebbar LH, Benjouad A, Morjani H, Merghoub N, El Haddar S, Humam M, Christen P, Hostettmann K, Bekkouche K, Amzazi S.

Therapie. 2009 Mar-Apr;64(2):121-7. doi: 10.2515/therapie/2009015. Epub 2009 Aug 11.

PMID:
19664406
19.

Withanolides-induced breast cancer cell death is correlated with their ability to inhibit heat protein 90.

Wang HC, Tsai YL, Wu YC, Chang FR, Liu MH, Chen WY, Wu CC.

PLoS One. 2012;7(5):e37764. doi: 10.1371/journal.pone.0037764. Epub 2012 May 31.

20.

Chlorinated and diepoxy withanolides from Withania somnifera and their cytotoxic effects against human lung cancer cell line.

Choudhary MI, Hussain S, Yousuf S, Dar A, Mudassar, Atta-ur-Rahman.

Phytochemistry. 2010 Dec;71(17-18):2205-9. doi: 10.1016/j.phytochem.2010.08.019. Epub 2010 Oct 31.

PMID:
21044792

Supplemental Content

Support Center