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Items: 1 to 20 of 100

1.

Platelet-activating factor antagonists enhance intracellular degradation of amyloid-β42 in neurons via regulation of cholesterol ester hydrolases.

Simmons C, Ingham V, Williams A, Bate C.

Alzheimers Res Ther. 2014 Mar 13;6(2):15. doi: 10.1186/alzrt245. eCollection 2014.

2.

Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-β oligomers.

McHale-Owen H, Bate C.

Biochim Biophys Acta. 2018 Mar;1864(3):649-659. doi: 10.1016/j.bbadis.2017.12.017. Epub 2017 Dec 13.

PMID:
29247837
3.

Glimepiride protects neurons against amyloid-β-induced synapse damage.

Osborne C, West E, Nolan W, McHale-Owen H, Williams A, Bate C.

Neuropharmacology. 2016 Feb;101:225-36. doi: 10.1016/j.neuropharm.2015.09.030. Epub 2015 Oct 8.

PMID:
26432105
4.

Inhibition of phospholipase A2 increased the removal of the prion derived peptide PrP82-146 from cultured neurons.

Bate C, Ingham V, Williams A.

Neuropharmacology. 2011 Feb-Mar;60(2-3):365-72. doi: 10.1016/j.neuropharm.2010.10.001. Epub 2010 Oct 8.

PMID:
20934441
5.
6.

Squalestatin protects neurons and reduces the activation of cytoplasmic phospholipase A2 by Abeta(1-42).

Bate C, Williams A.

Neuropharmacology. 2007 Aug;53(2):222-31. Epub 2007 May 18.

PMID:
17583757
7.

The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-β.

West E, Osborne C, Bate C.

J Cell Sci. 2017 Sep 15;130(18):3050-3059. doi: 10.1242/jcs.205484. Epub 2017 Jul 31.

8.

Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-β oligomers released from 7PA2 cells.

Williams RSB, Bate C.

Neuropharmacology. 2018 Jan;128:54-62. doi: 10.1016/j.neuropharm.2017.09.031. Epub 2017 Sep 22.

PMID:
28947378
9.

Differences in the cellular uptake and intracellular itineraries of amyloid beta proteins 40 and 42: ramifications for the Alzheimer's drug discovery.

Omtri RS, Davidson MW, Arumugam B, Poduslo JF, Kandimalla KK.

Mol Pharm. 2012 Jul 2;9(7):1887-97. doi: 10.1021/mp200530q. Epub 2012 Jun 1.

10.

Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-β.

Bate C.

J Exp Neurosci. 2017 Dec 6;11:1179069517733096. doi: 10.1177/1179069517733096. eCollection 2017.

11.

Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease.

Armato U, Chiarini A, Chakravarthy B, Chioffi F, Pacchiana R, Colarusso E, Whitfield JF, Dal Prà I.

Biochim Biophys Acta. 2013 Oct;1832(10):1634-52. doi: 10.1016/j.bbadis.2013.04.020. Epub 2013 Apr 26.

12.

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons.

Hama E, Shirotani K, Iwata N, Saido TC.

J Biol Chem. 2004 Jul 16;279(29):30259-64. Epub 2004 Apr 20.

13.
14.

The phospholipase A2 pathway controls a synaptic cholesterol ester cycle and synapse damage.

Osborne C, West E, Bate C.

J Cell Sci. 2018 Apr 19;131(8). pii: jcs211789. doi: 10.1242/jcs.211789.

PMID:
29588394
15.

Genome-wide analysis of Saccharomyces cerevisiae identifies cellular processes affecting intracellular aggregation of Alzheimer's amyloid-β42: importance of lipid homeostasis.

Nair S, Traini M, Dawes IW, Perrone GG.

Mol Biol Cell. 2014 Aug 1;25(15):2235-49. doi: 10.1091/mbc.E13-04-0216. Epub 2014 May 28.

16.

Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's Disease.

Chiarini A, Armato U, Liu D, Dal Prà I.

Front Physiol. 2016 Apr 26;7:134. doi: 10.3389/fphys.2016.00134. eCollection 2016. Review.

17.

Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's disease.

Evangelisti E, Wright D, Zampagni M, Cascella R, Fiorillo C, Bagnoli S, Relini A, Nichino D, Scartabelli T, Nacmias B, Sorbi S, Cecchi C.

Curr Alzheimer Res. 2013 Feb;10(2):143-53.

PMID:
22950913
18.

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.

Biochemistry. 1998 Nov 24;37(47):16465-71.

PMID:
9843412
19.
20.

Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.

Kawarabayashi T, Shoji M, Younkin LH, Wen-Lang L, Dickson DW, Murakami T, Matsubara E, Abe K, Ashe KH, Younkin SG.

J Neurosci. 2004 Apr 14;24(15):3801-9.

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