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Items: 1 to 20 of 105

1.

Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment.

Li H, Yang X, Yang G, Hong Z, Zhou L, Yin P, Xiao Y, Chen L, Chung RT, Zhang L.

J Virol. 2014 Jun;88(11):5956-66. doi: 10.1128/JVI.03738-13. Epub 2014 Mar 12.

2.

A role for retromer in hepatitis C virus replication.

Yin P, Hong Z, Yang X, Chung RT, Zhang L.

Cell Mol Life Sci. 2016 Feb;73(4):869-81. doi: 10.1007/s00018-015-2027-7. Epub 2015 Aug 23.

PMID:
26298293
4.

Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication.

Berger KL, Kelly SM, Jordan TX, Tartell MA, Randall G.

J Virol. 2011 Sep;85(17):8870-83. doi: 10.1128/JVI.00059-11. Epub 2011 Jun 22.

5.

Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity.

Bianco A, Reghellin V, Donnici L, Fenu S, Alvarez R, Baruffa C, Peri F, Pagani M, Abrignani S, Neddermann P, De Francesco R.

PLoS Pathog. 2012;8(3):e1002576. doi: 10.1371/journal.ppat.1002576. Epub 2012 Mar 8.

6.

The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A.

Reiss S, Harak C, Romero-Brey I, Radujkovic D, Klein R, Ruggieri A, Rebhan I, Bartenschlager R, Lohmann V.

PLoS Pathog. 2013 May;9(5):e1003359. doi: 10.1371/journal.ppat.1003359. Epub 2013 May 9.

7.

ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication.

Zhang L, Hong Z, Lin W, Shao RX, Goto K, Hsu VW, Chung RT.

PLoS One. 2012;7(2):e32135. doi: 10.1371/journal.pone.0032135. Epub 2012 Feb 16.

8.

Modulation of hepatitis C virus genome replication by glycosphingolipids and four-phosphate adaptor protein 2.

Khan I, Katikaneni DS, Han Q, Sanchez-Felipe L, Hanada K, Ambrose RL, Mackenzie JM, Konan KV.

J Virol. 2014 Nov;88(21):12276-95. doi: 10.1128/JVI.00970-14. Epub 2014 Aug 13.

9.

Seed sequence-matched controls reveal limitations of small interfering RNA knockdown in functional and structural studies of hepatitis C virus NS5A-MOBKL1B interaction.

Chung HY, Gu M, Buehler E, MacDonald MR, Rice CM.

J Virol. 2014 Oct;88(19):11022-33. doi: 10.1128/JVI.01582-14. Epub 2014 Jul 16.

10.

Mapping of functional domains of the lipid kinase phosphatidylinositol 4-kinase type III alpha involved in enzymatic activity and hepatitis C virus replication.

Harak C, Radujkovic D, Taveneau C, Reiss S, Klein R, Bressanelli S, Lohmann V.

J Virol. 2014 Sep 1;88(17):9909-26. doi: 10.1128/JVI.01063-14. Epub 2014 Jun 11.

11.

Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment.

Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V, Bartenschlager R.

Cell Host Microbe. 2011 Jan 20;9(1):32-45. doi: 10.1016/j.chom.2010.12.002.

12.

Vinexin β Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation.

Xiong W, Yang J, Wang M, Wang H, Rao Z, Zhong C, Xin X, Mo L, Yu S, Shen C, Zheng C.

J Virol. 2015 Jul;89(14):7385-400. doi: 10.1128/JVI.00567-15. Epub 2015 May 13.

13.

Daclatasvir inhibits hepatitis C virus NS5A motility and hyper-accumulation of phosphoinositides.

Chukkapalli V, Berger KL, Kelly SM, Thomas M, Deiters A, Randall G.

Virology. 2015 Feb;476:168-79. doi: 10.1016/j.virol.2014.12.018. Epub 2014 Dec 26.

14.

Y-Box Binding Protein 1 Stabilizes Hepatitis C Virus NS5A via Phosphorylation-Mediated Interaction with NS5A To Regulate Viral Propagation.

Wang WT, Tsai TY, Chao CH, Lai BY, Wu Lee YH.

J Virol. 2015 Nov;89(22):11584-602. doi: 10.1128/JVI.01513-15. Epub 2015 Sep 9.

15.

Cytosolic phospholipase A2 gamma is involved in hepatitis C virus replication and assembly.

Xu S, Pei R, Guo M, Han Q, Lai J, Wang Y, Wu C, Zhou Y, Lu M, Chen X.

J Virol. 2012 Dec;86(23):13025-37. doi: 10.1128/JVI.01785-12. Epub 2012 Sep 26.

16.
17.

NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase IIIα complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes.

Reghellin V, Donnici L, Fenu S, Berno V, Calabrese V, Pagani M, Abrignani S, Peri F, De Francesco R, Neddermann P.

Antimicrob Agents Chemother. 2014 Dec;58(12):7128-40. doi: 10.1128/AAC.03293-14. Epub 2014 Sep 15.

18.

Involvement of hepatitis C virus NS5A hyperphosphorylation mediated by casein kinase I-α in infectious virus production.

Masaki T, Matsunaga S, Takahashi H, Nakashima K, Kimura Y, Ito M, Matsuda M, Murayama A, Kato T, Hirano H, Endo Y, Lemon SM, Wakita T, Sawasaki T, Suzuki T.

J Virol. 2014 Jul;88(13):7541-55. doi: 10.1128/JVI.03170-13. Epub 2014 Apr 23.

19.

Hepatitis C virus NS5A competes with PI4KB for binding to ACBD3 in a genotype-dependent manner.

Hong Z, Yang X, Yang G, Zhang L.

Antiviral Res. 2014 Jul;107:50-5. doi: 10.1016/j.antiviral.2014.04.012. Epub 2014 Apr 30.

PMID:
24792752
20.

Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein.

Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M.

PLoS Pathog. 2013;9(4):e1003302. doi: 10.1371/journal.ppat.1003302. Epub 2013 Apr 11.

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