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Items: 1 to 20 of 188


Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome.

Tejera P, O'Mahony DS, Owen CA, Wei Y, Wang Z, Gupta K, Su L, Villar J, Wurfel M, Christiani DC.

Am J Respir Cell Mol Biol. 2014 Aug;51(2):262-72. doi: 10.1165/rcmb.2013-0238OC.


Genetic polymorphisms of peptidase inhibitor 3 (elafin) are associated with acute respiratory distress syndrome.

Tejera P, Wang Z, Zhai R, Su L, Sheu CC, Taylor DM, Chen F, Gong MN, Thompson BT, Christiani DC.

Am J Respir Cell Mol Biol. 2009 Dec;41(6):696-704. doi: 10.1165/rcmb.2008-0410OC. Epub 2009 Feb 27.


A genome-wide expression analysis in blood identifies pre-elafin as a biomarker in ARDS.

Wang Z, Beach D, Su L, Zhai R, Christiani DC.

Am J Respir Cell Mol Biol. 2008 Jun;38(6):724-32. doi: 10.1165/rcmb.2007-0354OC. Epub 2008 Jan 18.


Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome.

Sun X, Ma SF, Wade MS, Acosta-Herrera M, Villar J, Pino-Yanes M, Zhou T, Liu B, Belvitch P, Moitra J, Han YJ, Machado R, Noth I, Natarajan V, Dudek SM, Jacobson JR, Flores C, Garcia JG.

Am J Physiol Lung Cell Mol Physiol. 2013 Oct 1;305(7):L467-77. doi: 10.1152/ajplung.00010.2013. Epub 2013 Aug 2.


Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development.

Wang Z, Chen F, Zhai R, Zhang L, Su L, Lin X, Thompson T, Christiani DC.

PLoS One. 2009;4(2):e4380. doi: 10.1371/journal.pone.0004380. Epub 2009 Feb 6.


Identification of novel functional sequence variants in the gene for peptidase inhibitor 3.

Chowdhury MA, Kuivaniemi H, Romero R, Edwin S, Chaiworapongsa T, Tromp G.

BMC Med Genet. 2006 May 23;7:49.


IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist.

Meyer NJ, Feng R, Li M, Zhao Y, Sheu CC, Tejera P, Gallop R, Bellamy S, Rushefski M, Lanken PN, Aplenc R, O'Keefe GE, Wurfel MM, Christiani DC, Christie JD.

Am J Respir Crit Care Med. 2013 May 1;187(9):950-9. doi: 10.1164/rccm.201208-1501OC.


Pre-B-cell colony-enhancing factor gene polymorphisms and risk of acute respiratory distress syndrome.

Bajwa EK, Yu CL, Gong MN, Thompson BT, Christiani DC.

Crit Care Med. 2007 May;35(5):1290-5.


Secretory leukocyte protease inhibitor (SLPI) is, like its homologue trappin-2 (pre-elafin), a transglutaminase substrate.

Baranger K, Zani ML, Labas V, Dallet-Choisy S, Moreau T.

PLoS One. 2011;6(6):e20976. doi: 10.1371/journal.pone.0020976. Epub 2011 Jun 7.


Secretory leukocyte proteinase inhibitor is preferentially increased in patients with acute respiratory distress syndrome.

Sallenave JM, Donnelly SC, Grant IS, Robertson C, Gauldie J, Haslett C.

Eur Respir J. 1999 May;13(5):1029-36.


Inhibitor kappaB-alpha haplotype GTC is associated with susceptibility to acute respiratory distress syndrome in Caucasians.

Zhai R, Zhou W, Gong MN, Thompson BT, Su L, Yu C, Kraft P, Christiani DC.

Crit Care Med. 2007 Mar;35(3):893-8.


Protease inhibitors derived from elafin and SLPI and engineered to have enhanced specificity towards neutrophil serine proteases.

Zani ML, Baranger K, Guyot N, Dallet-Choisy S, Moreau T.

Protein Sci. 2009 Mar;18(3):579-94. doi: 10.1002/pro.64.


Protective effects of elafin against adult asthma.

Tsai YS, Tseng YT, Chen PS, Lin MC, Wu CC, Huang MS, Wang CC, Chen KS, Lin YC, Wang TN.

Allergy Asthma Proc. 2016 Mar-Apr;37(2):15-24. doi: 10.2500/aap.2016.37.3932.


Genetic predisposition to acute respiratory distress syndrome in patients with severe sepsis.

Cardinal-Fernández P, Ferruelo A, El-Assar M, Santiago C, Gómez-Gallego F, Martín-Pellicer A, Frutos-Vivar F, Peñuelas O, Nin N, Esteban A, Lorente JA.

Shock. 2013 Mar;39(3):255-60. doi: 10.1097/SHK.0b013e3182866ff9.


Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma.

Christie JD, Ma SF, Aplenc R, Li M, Lanken PN, Shah CV, Fuchs B, Albelda SM, Flores C, Garcia JG.

Crit Care Med. 2008 Oct;36(10):2794-800.


Functional Assessment of Clubfoot Associated HOXA9, TPM1, and TPM2 Variants Suggests a Potential Gene Regulation Mechanism.

Weymouth KS, Blanton SH, Powell T, Patel CV, Savill SA, Hecht JT.

Clin Orthop Relat Res. 2016 Jul;474(7):1726-35. doi: 10.1007/s11999-016-4788-1. Epub 2016 Mar 28.


Adiponectin gene polymorphisms and acute respiratory distress syndrome susceptibility and mortality.

Ahasic AM, Zhao Y, Su L, Sheu CC, Thompson BT, Christiani DC.

PLoS One. 2014 Feb 19;9(2):e89170. doi: 10.1371/journal.pone.0089170. eCollection 2014.


Common variants of NFE2L2 gene predisposes to acute respiratory distress syndrome in patients with severe sepsis.

Acosta-Herrera M, Pino-Yanes M, Blanco J, Ballesteros JC, Ambrós A, Corrales A, Gandía F, Subirá C, Domínguez D, Baluja A, Añón JM, Adalia R, Pérez-Méndez L, Flores C, Villar J; GRECIA and GEN-SEP networks.

Crit Care. 2015 Jun 16;19:256. doi: 10.1186/s13054-015-0981-y.


Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin.

Tejera P, Meyer NJ, Chen F, Feng R, Zhao Y, O'Mahony DS, Li L, Sheu CC, Zhai R, Wang Z, Su L, Bajwa E, Ahasic AM, Clardy PF, Gong MN, Frank AJ, Lanken PN, Thompson BT, Christie JD, Wurfel MM, O'Keefe GE, Christiani DC.

J Med Genet. 2012 Nov;49(11):671-80. doi: 10.1136/jmedgenet-2012-100972. Epub 2012 Oct 9.

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