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Items: 1 to 20 of 140

1.

Synthesis of novel heterocyclic ring-fused 18β-glycyrrhetinic acid derivatives with antitumor and antimetastatic activity.

Gao C, Dai FJ, Cui HW, Peng SH, He Y, Wang X, Yi ZF, Qiu WW.

Chem Biol Drug Des. 2014 Aug;84(2):223-33. doi: 10.1111/cbdd.12308. Epub 2014 Apr 30.

PMID:
24612785
2.

Synthesis and antitumor activity of ring A modified glycyrrhetinic acid derivatives.

Csuk R, Schwarz S, Siewert B, Kluge R, Ströhl D.

Eur J Med Chem. 2011 Nov;46(11):5356-69. doi: 10.1016/j.ejmech.2011.08.038. Epub 2011 Aug 31.

PMID:
21959232
3.

Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives.

Liu Y, Qian K, Wang CY, Chen CH, Yang X, Lee KH.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7530-3. doi: 10.1016/j.bmcl.2012.10.041. Epub 2012 Oct 16.

PMID:
23122524
4.

A "natural" approach: synthesis and cytoxicity of monodesmosidic glycyrrhetinic acid glycosides.

Schwarz S, Siewert B, Xavier NM, Jesus AR, Rauter AP, Csuk R.

Eur J Med Chem. 2014 Jan 24;72:78-83. doi: 10.1016/j.ejmech.2013.11.024. Epub 2013 Dec 5.

PMID:
24361520
5.

Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid.

Csuk R, Schwarz S, Kluge R, Ströhl D.

Eur J Med Chem. 2010 Dec;45(12):5718-23. doi: 10.1016/j.ejmech.2010.09.028. Epub 2010 Sep 17.

PMID:
20884085
6.

Improvement of the cytotoxicity and tumor selectivity of glycyrrhetinic acid by derivatization with bifunctional amino acids.

Csuk R, Schwarz S, Kluge R, Ströhl D.

Arch Pharm (Weinheim). 2011 Aug;344(8):505-13. doi: 10.1002/ardp.201100030. Epub 2011 Jun 14.

PMID:
21674592
7.

Synthesis and evaluation of triazole linked glycosylated 18β-glycyrrhetinic acid derivatives as anticancer agents.

Parida PK, Sau A, Ghosh T, Jana K, Biswas K, Raha S, Misra AK.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3865-8. doi: 10.1016/j.bmcl.2014.06.054. Epub 2014 Jun 27.

PMID:
25027936
8.

Synthesis and antitumour activity of glycyrrhetinic acid derivatives.

Schwarz S, Csuk R.

Bioorg Med Chem. 2010 Nov 1;18(21):7458-74. doi: 10.1016/j.bmc.2010.08.054. Epub 2010 Sep 18.

PMID:
20932766
9.

18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells.

Lin KW, Huang AM, Hour TC, Yang SC, Pu YS, Lin CN.

Bioorg Med Chem. 2011 Jul 15;19(14):4274-85. doi: 10.1016/j.bmc.2011.05.054. Epub 2011 May 30.

PMID:
21696969
10.

Synthesis and pro-apoptotic activity of novel glycyrrhetinic acid derivatives.

Logashenko EB, Salomatina OV, Markov AV, Korchagina DV, Salakhutdinov NF, Tolstikov GA, Vlassov VV, Zenkova MA.

Chembiochem. 2011 Mar 21;12(5):784-94. doi: 10.1002/cbic.201000618. Epub 2011 Feb 15.

11.

Does one keto group matter? Structure-activity relationships of glycyrrhetinic acid derivatives modified at position C-11.

Csuk R, Schwarz S, Kluge R, Ströhl D.

Arch Pharm (Weinheim). 2012 Jan;345(1):28-32. doi: 10.1002/ardp.201000327. Epub 2011 Nov 11.

PMID:
22076975
12.

Conversions at C-30 of glycyrrhetinic acid and their impact on antitumor activity.

Csuk R, Schwarz S, Siewert B, Kluge R, Ströhl D.

Arch Pharm (Weinheim). 2012 Mar;345(3):223-30. doi: 10.1002/ardp.201100046. Epub 2011 Oct 14.

PMID:
21997717
13.
14.

[Design, synthesis and antiproliferative activity in cancer cells of novel 18β-glycyrrhetinic acid derivatives].

Huang M, Li K, Jin SY, Cui TX, Liu D, Zhao LX.

Yao Xue Xue Bao. 2015 Oct;50(10):1263-71. Chinese.

PMID:
26837172
15.

Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives.

Li Y, Feng L, Song ZF, Li HB, Huai QY.

Molecules. 2016 Feb 6;21(2). pii: E199. doi: 10.3390/molecules21020199.

16.

The synthesis of 18beta-glycyrrhetinic acid derivatives which have increased antiproliferative and apoptotic effects in leukemia cells.

Liu D, Song D, Guo G, Wang R, Lv J, Jing Y, Zhao L.

Bioorg Med Chem. 2007 Aug 15;15(16):5432-9. Epub 2007 May 26.

PMID:
17566745
17.

Synthesis of heterocycle-modified betulinic acid derivatives as antitumor agents.

Cui HW, He Y, Wang J, Gao W, Liu T, Qin M, Wang X, Gao C, Wang Y, Liu MY, Yi Z, Qiu WW.

Eur J Med Chem. 2015 May 5;95:240-8. doi: 10.1016/j.ejmech.2015.03.048. Epub 2015 Mar 21.

PMID:
25817774
18.

Inhibition of protein kinase C α/βII and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells.

Song J, Ko HS, Sohn EJ, Kim B, Kim JH, Kim HJ, Kim C, Kim JE, Kim SH.

Bioorg Med Chem Lett. 2014 Feb 15;24(4):1188-91. doi: 10.1016/j.bmcl.2013.12.111. Epub 2014 Jan 3.

PMID:
24461294
19.

18beta-Glycyrrhetinic acid induces apoptotic cell death in SiHa cells and exhibits a synergistic effect against antibiotic anti-cancer drug toxicity.

Lee CS, Kim YJ, Lee MS, Han ES, Lee SJ.

Life Sci. 2008 Sep 26;83(13-14):481-9. doi: 10.1016/j.lfs.2008.07.014. Epub 2008 Aug 5.

PMID:
18721818
20.

N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)-glycyrrhetinamide (6b): a novel anticancer glycyrrhetinic acid derivative that targets the proteasome and displays anti-kinase activity.

Lallemand B, Chaix F, Bury M, Bruyère C, Ghostin J, Becker JP, Delporte C, Gelbcke M, Mathieu V, Dubois J, Prévost M, Jabin I, Kiss R.

J Med Chem. 2011 Oct 13;54(19):6501-13. doi: 10.1021/jm200285z. Epub 2011 Sep 2.

PMID:
21888390

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