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Items: 1 to 20 of 70

1.

Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells.

Konitsiotis AD, Chang SC, Jovanović B, Ciepla P, Masumoto N, Palmer CP, Tate EW, Couchman JR, Magee AI.

PLoS One. 2014 Mar 7;9(3):e89899. doi: 10.1371/journal.pone.0089899. eCollection 2014.

2.
3.

Membrane topology of hedgehog acyltransferase.

Matevossian A, Resh MD.

J Biol Chem. 2015 Jan 23;290(4):2235-43. doi: 10.1074/jbc.M114.625764. Epub 2014 Dec 8.

4.

Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma.

Petrova E, Matevossian A, Resh MD.

Oncogene. 2015 Jan 8;34(2):263-8. doi: 10.1038/onc.2013.575. Epub 2014 Jan 27.

5.

Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog.

Buglino JA, Resh MD.

J Biol Chem. 2008 Aug 8;283(32):22076-88. doi: 10.1074/jbc.M803901200. Epub 2008 Jun 4.

6.

Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling.

Callier P, Calvel P, Matevossian A, Makrythanasis P, Bernard P, Kurosaka H, Vannier A, Thauvin-Robinet C, Borel C, Mazaud-Guittot S, Rolland A, Desdoits-Lethimonier C, Guipponi M, Zimmermann C, Stévant I, Kuhne F, Conne B, Santoni F, Lambert S, Huet F, Mugneret F, Jaruzelska J, Faivre L, Wilhelm D, Jégou B, Trainor PA, Resh MD, Antonarakis SE, Nef S.

PLoS Genet. 2014 May 1;10(5):e1004340. doi: 10.1371/journal.pgen.1004340. eCollection 2014 May.

7.

Identification of N-terminal residues of Sonic Hedgehog important for palmitoylation by Hedgehog acyltransferase.

Hardy RY, Resh MD.

J Biol Chem. 2012 Dec 14;287(51):42881-9. doi: 10.1074/jbc.M112.426833. Epub 2012 Oct 30.

8.

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.

Petrova E, Rios-Esteves J, Ouerfelli O, Glickman JF, Resh MD.

Nat Chem Biol. 2013 Apr;9(4):247-9. doi: 10.1038/nchembio.1184. Epub 2013 Feb 17.

9.

Palmitoylation of Hedgehog proteins.

Buglino JA, Resh MD.

Vitam Horm. 2012;88:229-52. doi: 10.1016/B978-0-12-394622-5.00010-9. Review.

10.
11.

Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase.

Lanyon-Hogg T, Masumoto N, Bodakh G, Konitsiotis AD, Thinon E, Rodgers UR, Owens RJ, Magee AI, Tate EW.

Anal Biochem. 2015 Dec 1;490:66-72. doi: 10.1016/j.ab.2015.08.025. Epub 2015 Sep 1.

12.

Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.

Rodgers UR, Lanyon-Hogg T, Masumoto N, Ritzefeld M, Burke R, Blagg J, Magee AI, Tate EW.

ACS Chem Biol. 2016 Dec 16;11(12):3256-3262. Epub 2016 Oct 25.

13.

Topological analysis of Hedgehog acyltransferase, a multipalmitoylated transmembrane protein.

Konitsiotis AD, Jovanović B, Ciepla P, Spitaler M, Lanyon-Hogg T, Tate EW, Magee AI.

J Biol Chem. 2015 Feb 6;290(6):3293-307. doi: 10.1074/jbc.M114.614578. Epub 2014 Dec 12.

14.

Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects.

Dennis JF, Kurosaka H, Iulianella A, Pace J, Thomas N, Beckham S, Williams T, Trainor PA.

PLoS Genet. 2012;8(10):e1002927. doi: 10.1371/journal.pgen.1002927. Epub 2012 Oct 4.

16.

Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer.

Nakashima H, Nakamura M, Yamaguchi H, Yamanaka N, Akiyoshi T, Koga K, Yamaguchi K, Tsuneyoshi M, Tanaka M, Katano M.

Cancer Res. 2006 Jul 15;66(14):7041-9.

17.

Palmitoylation of proteins in cancer.

Resh MD.

Biochem Soc Trans. 2017 Apr 15;45(2):409-416. doi: 10.1042/BST20160233. Review.

PMID:
28408481
18.

Reoxygenation from chronic hypoxia promotes metastatic processes in pancreatic cancer through the Hedgehog signaling.

Morifuji Y, Onishi H, Iwasaki H, Imaizumi A, Nakano K, Tanaka M, Katano M.

Cancer Sci. 2014 Mar;105(3):324-33. doi: 10.1111/cas.12348. Epub 2014 Feb 11.

19.

Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions.

Chang SC, Mulloy B, Magee AI, Couchman JR.

J Biol Chem. 2011 Dec 30;286(52):44391-402. doi: 10.1074/jbc.M111.285361. Epub 2011 Nov 2.

20.

Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway.

Yoo YA, Kang MH, Kim JS, Oh SC.

Carcinogenesis. 2008 Mar;29(3):480-90. doi: 10.1093/carcin/bgm281. Epub 2008 Jan 3.

PMID:
18174246

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