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Long interspersed element-1 protein expression is a hallmark of many human cancers.

Rodić N, Sharma R, Sharma R, Zampella J, Dai L, Taylor MS, Hruban RH, Iacobuzio-Donahue CA, Maitra A, Torbenson MS, Goggins M, Shih IeM, Duffield AS, Montgomery EA, Gabrielson E, Netto GJ, Lotan TL, De Marzo AM, Westra W, Binder ZA, Orr BA, Gallia GL, Eberhart CG, Boeke JD, Harris CR, Burns KH.

Am J Pathol. 2014 May;184(5):1280-6. doi: 10.1016/j.ajpath.2014.01.007. Epub 2014 Mar 6.


Enhanced expression of LINE-1-encoded ORF2 protein in early stages of colon and prostate transformation.

De Luca C, Guadagni F, Sinibaldi-Vallebona P, Sentinelli S, Gallucci M, Hoffmann A, Schumann GG, Spadafora C, Sciamanna I.

Oncotarget. 2016 Jan 26;7(4):4048-61. doi: 10.18632/oncotarget.6767.


Expression profiles of SnoN in normal and cancerous human tissues support its tumor suppressor role in human cancer.

Jahchan NS, Ouyang G, Luo K.

PLoS One. 2013;8(2):e55794. doi: 10.1371/journal.pone.0055794. Epub 2013 Feb 13.


Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers.

Suh KS, Crutchley JM, Koochek A, Ryscavage A, Bhat K, Tanaka T, Oshima A, Fitzgerald P, Yuspa SH.

Clin Cancer Res. 2007 Jan 1;13(1):121-31.


LINE-1 ORF-1p functions as a novel HGF/ETS-1 signaling pathway co-activator and promotes the growth of MDA-MB-231 cell.

Yang Q, Feng F, Zhang F, Wang C, Lu Y, Gao X, Zhu Y, Yang Y.

Cell Signal. 2013 Dec;25(12):2652-60. doi: 10.1016/j.cellsig.2013.08.029. Epub 2013 Sep 4.


CD43 promotes cell growth and helps to evade FAS-mediated apoptosis in non-hematopoietic cancer cells lacking the tumor suppressors p53 or ARF.

Kadaja-Saarepuu L, Laos S, Jääger K, Viil J, Balikova A, Lõoke M, Hansson GC, Maimets T.

Oncogene. 2008 Mar 13;27(12):1705-15. Epub 2007 Sep 24.


[The cooperation between p53 and Ras in tumorigenesis].

Wei YY, Hou J, Tang WR, Luo Y.

Yi Chuan. 2012 Dec;34(12):1513-21. Review. Chinese.


Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility.

Xia M, Land H.

Nat Struct Mol Biol. 2007 Mar;14(3):215-23. Epub 2007 Feb 18.


Wild-type p53 in cancer cells: when a guardian turns into a blackguard.

Kim E, Giese A, Deppert W.

Biochem Pharmacol. 2009 Jan 1;77(1):11-20. doi: 10.1016/j.bcp.2008.08.030. Epub 2008 Sep 3. Review.


Restoration of p53 function leads to tumour regression in vivo.

Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T.

Nature. 2007 Feb 8;445(7128):661-5. Epub 2007 Jan 24.


Recombinant, refolded tetrameric p53 and gonadotropin-releasing hormone-p53 slow proliferation and induce apoptosis in p53-deficient cancer cells.

Lafevre-Bernt M, Wu S, Lin X.

Mol Cancer Ther. 2008 Jun;7(6):1420-9. doi: 10.1158/1535-7163.MCT-08-0078.


Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution.

Ewing AD, Gacita A, Wood LD, Ma F, Xing D, Kim MS, Manda SS, Abril G, Pereira G, Makohon-Moore A, Looijenga LH, Gillis AJ, Hruban RH, Anders RA, Romans KE, Pandey A, Iacobuzio-Donahue CA, Vogelstein B, Kinzler KW, Kazazian HH Jr, Solyom S.

Genome Res. 2015 Oct;25(10):1536-45. doi: 10.1101/gr.196238.115. Epub 2015 Aug 10.


TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer.

Fu HL, Ma Y, Lu LG, Hou P, Li BJ, Jin WL, Cui DX.

J Biomed Nanotechnol. 2014 Jul;10(7):1217-30.


Role of Stat3 in regulating p53 expression and function.

Niu G, Wright KL, Ma Y, Wright GM, Huang M, Irby R, Briggs J, Karras J, Cress WD, Pardoll D, Jove R, Chen J, Yu H.

Mol Cell Biol. 2005 Sep;25(17):7432-40.


Epithelial cell-derived periostin functions as a tumor suppressor in gastric cancer through stabilizing p53 and E-cadherin proteins via the Rb/E2F1/p14ARF/Mdm2 signaling pathway.

Lv H, Liu R, Fu J, Yang Q, Shi J, Chen P, Ji M, Shi B, Hou P.

Cell Cycle. 2014;13(18):2962-74. doi: 10.4161/15384101.2014.947203.


PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.

Li Y, Park J, Piao L, Kong G, Kim Y, Park KA, Zhang T, Hong J, Hur GM, Seok JH, Choi SW, Yoo BC, Hemmings BA, Brazil DP, Kim SH, Park J.

Cell Signal. 2013 Jan;25(1):74-84. doi: 10.1016/j.cellsig.2012.09.009. Epub 2012 Sep 11.


Long interspersed nucleotide acid element-1 ORF-1 protein promotes proliferation and invasion of human colorectal cancer LoVo cells through enhancing ETS-1 activity.

Li MY, Zhu M, Feng F, Cai FY, Fan KC, Jiang H, Wang ZQ, Linghu EQ.

Genet Mol Res. 2014 Apr 14;13(3):6981-94. doi: 10.4238/2014.April.14.13.


Mutant p53 accumulation in human breast cancer is not an intrinsic property or dependent on structural or functional disruption but is regulated by exogenous stress and receptor status.

Bouchalova P, Nenutil R, Muller P, Hrstka R, Appleyard MV, Murray K, Jordan LB, Purdie CA, Quinlan P, Thompson AM, Vojtesek B, Coates PJ.

J Pathol. 2014 Jul;233(3):238-46. doi: 10.1002/path.4356. Epub 2014 May 21.


HCCRBP-3 induces tumorigenesis through direct interaction with HCCR-1 in human cancers.

Ha SA, Kim HK, Yoo JA, Kim S, Shin SM, Gong GH, Lee YK, Kim JW.

Mol Carcinog. 2014 Jan;53(1):30-7. doi: 10.1002/mc.21945. Epub 2012 Jul 31.


The onco-embryonic antigen ROR1 is expressed by a variety of human cancers.

Zhang S, Chen L, Wang-Rodriguez J, Zhang L, Cui B, Frankel W, Wu R, Kipps TJ.

Am J Pathol. 2012 Dec;181(6):1903-10. doi: 10.1016/j.ajpath.2012.08.024. Epub 2012 Oct 4.

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