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Items: 1 to 20 of 106

1.

Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression.

Fairfax BP, Humburg P, Makino S, Naranbhai V, Wong D, Lau E, Jostins L, Plant K, Andrews R, McGee C, Knight JC.

Science. 2014 Mar 7;343(6175):1246949. doi: 10.1126/science.1246949.

2.

Large-scale East-Asian eQTL mapping reveals novel candidate genes for LD mapping and the genomic landscape of transcriptional effects of sequence variants.

Narahara M, Higasa K, Nakamura S, Tabara Y, Kawaguchi T, Ishii M, Matsubara K, Matsuda F, Yamada R.

PLoS One. 2014 Jun 23;9(6):e100924. doi: 10.1371/journal.pone.0100924. eCollection 2014.

3.

Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans.

Rotival M, Zeller T, Wild PS, Maouche S, Szymczak S, Schillert A, Castagné R, Deiseroth A, Proust C, Brocheton J, Godefroy T, Perret C, Germain M, Eleftheriadis M, Sinning CR, Schnabel RB, Lubos E, Lackner KJ, Rossmann H, Münzel T, Rendon A; Cardiogenics Consortium, Erdmann J, Deloukas P, Hengstenberg C, Diemert P, Montalescot G, Ouwehand WH, Samani NJ, Schunkert H, Tregouet DA, Ziegler A, Goodall AH, Cambien F, Tiret L, Blankenberg S.

PLoS Genet. 2011 Dec;7(12):e1002367. doi: 10.1371/journal.pgen.1002367. Epub 2011 Dec 1.

4.

Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling.

Ferreira MA, Jansen R, Willemsen G, Penninx B, Bain LM, Vicente CT, Revez JA, Matheson MC, Hui J, Tung JY, Baltic S, Le Souëf P, Montgomery GW, Martin NG, Robertson CF, James A, Thompson PJ, Boomsma DI, Hopper JL, Hinds DA, Werder RB, Phipps S; Australian Asthma Genetics Consortium Collaborators.

J Allergy Clin Immunol. 2017 Apr;139(4):1148-1157. doi: 10.1016/j.jaci.2016.07.017. Epub 2016 Aug 20.

PMID:
27554816
5.

Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.

Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, McCabe C, Paik HI, Srivastava GP, Raychaudhuri S, Hafler DA, Koller D, Regev A, Hacohen N, Mathis D, Benoist C, Stranger BE, De Jager PL.

Science. 2014 May 2;344(6183):519-23. doi: 10.1126/science.1249547.

6.

Immunogenetics: tracking immune activity across the genome.

Kugelberg E.

Nat Rev Immunol. 2014 Apr;14(4):212. doi: 10.1038/nri3653. No abstract available.

PMID:
24662379
7.

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes.

Kim S, Becker J, Bechheim M, Kaiser V, Noursadeghi M, Fricker N, Beier E, Klaschik S, Boor P, Hess T, Hofmann A, Holdenrieder S, Wendland JR, Fröhlich H, Hartmann G, Nöthen MM, Müller-Myhsok B, Pütz B, Hornung V, Schumacher J.

Nat Commun. 2014 Oct 20;5:5236. doi: 10.1038/ncomms6236.

PMID:
25327457
8.

Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network.

Richard AC, Peters JE, Lee JC, Vahedi G, Schäffer AA, Siegel RM, Lyons PA, Smith KG.

Genome Med. 2016 Jul 19;8(1):76. doi: 10.1186/s13073-016-0329-5.

9.

Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies.

Ellinghaus D, Zhang H, Zeissig S, Lipinski S, Till A, Jiang T, Stade B, Bromberg Y, Ellinghaus E, Keller A, Rivas MA, Skieceviciene J, Doncheva NT, Liu X, Liu Q, Jiang F, Forster M, Mayr G, Albrecht M, Häsler R, Boehm BO, Goodall J, Berzuini CR, Lee J, Andersen V, Vogel U, Kupcinskas L, Kayser M, Krawczak M, Nikolaus S, Weersma RK, Ponsioen CY, Sans M, Wijmenga C, Strachan DP, McArdle WL, Vermeire S, Rutgeerts P, Sanderson JD, Mathew CG, Vatn MH, Wang J, Nöthen MM, Duerr RH, Büning C, Brand S, Glas J, Winkelmann J, Illig T, Latiano A, Annese V, Halfvarson J, D'Amato M, Daly MJ, Nothnagel M, Karlsen TH, Subramani S, Rosenstiel P, Schreiber S, Parkes M, Franke A.

Gastroenterology. 2013 Aug;145(2):339-47. doi: 10.1053/j.gastro.2013.04.040. Epub 2013 Apr 25.

10.

Conditional entropy in variation-adjusted windows detects selection signatures associated with expression quantitative trait loci (eQTLs).

Handelman SK, Seweryn M, Smith RM, Hartmann K, Wang D, Pietrzak M, Johnson AD, Kloczkowski A, Sadee W.

BMC Genomics. 2015;16 Suppl 8:S8. doi: 10.1186/1471-2164-16-S8-S8. Epub 2015 Jun 18.

11.

Airway Epithelial Expression Quantitative Trait Loci Reveal Genes Underlying Asthma and Other Airway Diseases.

Luo W, Obeidat M, Di Narzo AF, Chen R, Sin DD, Paré PD, Hao K.

Am J Respir Cell Mol Biol. 2016 Feb;54(2):177-87. doi: 10.1165/rcmb.2014-0381OC.

12.

IRF8 and IRF3 cooperatively regulate rapid interferon-β induction in human blood monocytes.

Li P, Wong JJ, Sum C, Sin WX, Ng KQ, Koh MB, Chin KC.

Blood. 2011 Mar 10;117(10):2847-54. doi: 10.1182/blood-2010-07-294272. Epub 2011 Jan 12.

13.

Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs.

Brown CD, Mangravite LM, Engelhardt BE.

PLoS Genet. 2013;9(8):e1003649. doi: 10.1371/journal.pgen.1003649. Epub 2013 Aug 1.

14.

Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

Fehrmann RS, Jansen RC, Veldink JH, Westra HJ, Arends D, Bonder MJ, Fu J, Deelen P, Groen HJ, Smolonska A, Weersma RK, Hofstra RM, Buurman WA, Rensen S, Wolfs MG, Platteel M, Zhernakova A, Elbers CC, Festen EM, Trynka G, Hofker MH, Saris CG, Ophoff RA, van den Berg LH, van Heel DA, Wijmenga C, Te Meerman GJ, Franke L.

PLoS Genet. 2011 Aug;7(8):e1002197. doi: 10.1371/journal.pgen.1002197. Epub 2011 Aug 4.

15.

Genetics. A genomic road map for complex human disease.

Gregersen PK.

Science. 2014 Mar 7;343(6175):1087-8. doi: 10.1126/science.1251426. No abstract available.

PMID:
24604188
16.

Mapping eQTLs with RNA-seq reveals novel susceptibility genes, non-coding RNAs and alternative-splicing events in systemic lupus erythematosus.

Odhams CA, Cortini A, Chen L, Roberts AL, Viñuela A, Buil A, Small KS, Dermitzakis ET, Morris DL, Vyse TJ, Cunninghame Graham DS.

Hum Mol Genet. 2017 Mar 1;26(5):1003-1017. doi: 10.1093/hmg/ddw417.

17.

Lung eQTLs to help reveal the molecular underpinnings of asthma.

Hao K, Bossé Y, Nickle DC, Paré PD, Postma DS, Laviolette M, Sandford A, Hackett TL, Daley D, Hogg JC, Elliott WM, Couture C, Lamontagne M, Brandsma CA, van den Berge M, Koppelman G, Reicin AS, Nicholson DW, Malkov V, Derry JM, Suver C, Tsou JA, Kulkarni A, Zhang C, Vessey R, Opiteck GJ, Curtis SP, Timens W, Sin DD.

PLoS Genet. 2012;8(11):e1003029. doi: 10.1371/journal.pgen.1003029. Epub 2012 Nov 29. Erratum in: PLoS Genet. 2012 Dec;8(12). doi: 10.1371/annotation/80d53ac6-4f5d-4c34-b92b-3fec00d514ac.

18.

Expression Quantitative Trait Loci Information Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic Variation.

Croteau-Chonka DC, Rogers AJ, Raj T, McGeachie MJ, Qiu W, Ziniti JP, Stubbs BJ, Liang L, Martinez FD, Strunk RC, Lemanske RF Jr, Liu AH, Stranger BE, Carey VJ, Raby BA.

PLoS One. 2015 Oct 16;10(10):e0140758. doi: 10.1371/journal.pone.0140758. eCollection 2015. Review.

19.

Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis.

Beaudoin M, Goyette P, Boucher G, Lo KS, Rivas MA, Stevens C, Alikashani A, Ladouceur M, Ellinghaus D, Törkvist L, Goel G, Lagacé C, Annese V, Bitton A, Begun J, Brant SR, Bresso F, Cho JH, Duerr RH, Halfvarson J, McGovern DP, Radford-Smith G, Schreiber S, Schumm PL, Sharma Y, Silverberg MS, Weersma RK; Quebec IBD Genetics Consortium; NIDDK IBD Genetics Consortium; International IBD Genetics Consortium, D'Amato M, Vermeire S, Franke A, Lettre G, Xavier RJ, Daly MJ, Rioux JD.

PLoS Genet. 2013;9(9):e1003723. doi: 10.1371/journal.pgen.1003723. Epub 2013 Sep 12.

20.

Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.

Fairfax BP, Makino S, Radhakrishnan J, Plant K, Leslie S, Dilthey A, Ellis P, Langford C, Vannberg FO, Knight JC.

Nat Genet. 2012 Mar 25;44(5):502-10. doi: 10.1038/ng.2205.

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