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Selective inhibition of PI3K/Akt/mTOR signaling pathway regulates autophagy of macrophage and vulnerability of atherosclerotic plaque.

Zhai C, Cheng J, Mujahid H, Wang H, Kong J, Yin Y, Li J, Zhang Y, Ji X, Chen W.

PLoS One. 2014 Mar 5;9(3):e90563. doi: 10.1371/journal.pone.0090563. eCollection 2014.


Advanced glycation endproducts trigger autophagy in cadiomyocyte via RAGE/PI3K/AKT/mTOR pathway.

Hou X, Hu Z, Xu H, Xu J, Zhang S, Zhong Y, He X, Wang N.

Cardiovasc Diabetol. 2014 Apr 14;13:78. doi: 10.1186/1475-2840-13-78.


ROS-Dependent Activation of Autophagy through the PI3K/Akt/mTOR Pathway Is Induced by Hydroxysafflor Yellow A-Sonodynamic Therapy in THP-1 Macrophages.

Jiang Y, Kou J, Han X, Li X, Zhong Z, Liu Z, Zheng Y, Tian Y, Yang L.

Oxid Med Cell Longev. 2017;2017:8519169. doi: 10.1155/2017/8519169. Epub 2017 Jan 16.


HBx induces HepG-2 cells autophagy through PI3K/Akt-mTOR pathway.

Wang P, Guo QS, Wang ZW, Qian HX.

Mol Cell Biochem. 2013 Jan;372(1-2):161-8. doi: 10.1007/s11010-012-1457-x. Epub 2012 Sep 23.


Regulation of different components from Ophiopogon japonicus on autophagy in human lung adenocarcinoma A549Cells through PI3K/Akt/mTOR signaling pathway.

Chen J, Yuan J, Zhou L, Zhu M, Shi Z, Song J, Xu Q, Yin G, Lv Y, Luo Y, Jia X, Feng L.

Biomed Pharmacother. 2017 Mar;87:118-126. doi: 10.1016/j.biopha.2016.12.093. Epub 2016 Dec 31.


Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells.

Xu Z, Zhang Y, Jiang J, Yang Y, Shi R, Hao B, Zhang Z, Huang Z, Kim JW, Zhang G.

BMC Cancer. 2010 Apr 27;10:161. doi: 10.1186/1471-2407-10-161.


LY294002 and Rapamycin promote coxsackievirus-induced cytopathic effect and apoptosis via inhibition of PI3K/AKT/mTOR signaling pathway.

Chen Z, Yang L, Liu Y, Tang A, Li X, Zhang J, Yang Z.

Mol Cell Biochem. 2014 Jan;385(1-2):169-77. doi: 10.1007/s11010-013-1825-1. Epub 2013 Sep 27.


Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor.

Zou CY, Smith KD, Zhu QS, Liu J, McCutcheon IE, Slopis JM, Meric-Bernstam F, Peng Z, Bornmann WG, Mills GB, Lazar AJ, Pollock RE, Lev D.

Mol Cancer Ther. 2009 May;8(5):1157-68. doi: 10.1158/1535-7163.MCT-08-1008. Epub 2009 May 5.


Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma.

Vega F, Medeiros LJ, Leventaki V, Atwell C, Cho-Vega JH, Tian L, Claret FX, Rassidakis GZ.

Cancer Res. 2006 Jul 1;66(13):6589-97.


Dual inhibition of PI3K and mTOR mitigates compensatory AKT activation and improves tamoxifen response in breast cancer.

Chen X, Zhao M, Hao M, Sun X, Wang J, Mao Y, Zu L, Liu J, Shen Y, Wang J, Shen K.

Mol Cancer Res. 2013 Oct;11(10):1269-78. doi: 10.1158/1541-7786.MCR-13-0212. Epub 2013 Jun 27.


Procyanidins, from Castanea mollissima Bl. shell, induces autophagy following apoptosis associated with PI3K/AKT/mTOR inhibition in HepG2 cells.

Zhang H, Luo X, Ke J, Duan Y, He Y, Zhang D, Cai M, Sun G, Sun X.

Biomed Pharmacother. 2016 Jul;81:15-24. doi: 10.1016/j.biopha.2016.04.002. Epub 2016 Apr 6.


Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.

Zhang DM, Liu JS, Deng LJ, Chen MF, Yiu A, Cao HH, Tian HY, Fung KP, Kurihara H, Pan JX, Ye WC.

Carcinogenesis. 2013 Jun;34(6):1331-42. doi: 10.1093/carcin/bgt060. Epub 2013 Feb 7.


Puquitinib mesylate (XC-302) induces autophagy via inhibiting the PI3K/AKT/mTOR signaling pathway in nasopharyngeal cancer cells.

Wang KF, Yang H, Jiang WQ, Li S, Cai YC.

Int J Mol Med. 2015 Dec;36(6):1556-62. doi: 10.3892/ijmm.2015.2378. Epub 2015 Oct 16.


Ginsenoside Rg1 regulates innate immune responses in macrophages through differentially modulating the NF-κB and PI3K/Akt/mTOR pathways.

Wang Y, Liu Y, Zhang XY, Xu LH, Ouyang DY, Liu KP, Pan H, He J, He XH.

Int Immunopharmacol. 2014 Nov;23(1):77-84. doi: 10.1016/j.intimp.2014.07.028. Epub 2014 Aug 29.


Tanshinone IIA Affects Autophagy and Apoptosis of Glioma Cells by Inhibiting Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Signaling Pathway.

Ding L, Ding L, Wang S, Wang S, Wang W, Wang W, Lv P, Lv P, Zhao D, Zhao D, Chen F, Chen F, Meng T, Meng T, Dong L, Dong L, Qi L, Qi L.

Pharmacology. 2017;99(3-4):188-195. doi: 10.1159/000452340. Epub 2016 Nov 26.


Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3K/Akt/mTOR pathway.

Chen A, Xiong LJ, Tong Y, Mao M.

Mol Med Rep. 2013 Oct;8(4):1011-6. doi: 10.3892/mmr.2013.1628. Epub 2013 Aug 13.


Insulin inhibits inflammation and promotes atherosclerotic plaque stability via PI3K-Akt pathway activation.

Yan H, Ma Y, Li Y, Zheng X, Lv P, Zhang Y, Li J, Ma M, Zhang L, Li C, Zhang R, Gao F, Wang H, Tao L.

Immunol Lett. 2016 Feb;170:7-14. doi: 10.1016/j.imlet.2015.12.003. Epub 2015 Dec 8.


Selective clearance of macrophages in atherosclerotic plaques by autophagy.

Verheye S, Martinet W, Kockx MM, Knaapen MW, Salu K, Timmermans JP, Ellis JT, Kilpatrick DL, De Meyer GR.

J Am Coll Cardiol. 2007 Feb 13;49(6):706-15. Epub 2007 Jan 26.


Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.

Ikezoe T, Nishioka C, Bandobashi K, Yang Y, Kuwayama Y, Adachi Y, Takeuchi T, Koeffler HP, Taguchi H.

Leuk Res. 2007 May;31(5):673-82. Epub 2006 Sep 27.


Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia.

Badura S, Tesanovic T, Pfeifer H, Wystub S, Nijmeijer BA, Liebermann M, Falkenburg JH, Ruthardt M, Ottmann OG.

PLoS One. 2013 Nov 14;8(11):e80070. doi: 10.1371/journal.pone.0080070. eCollection 2013.

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