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STRAD pseudokinases regulate axogenesis and LKB1 stability.

Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A, Klug LR, Hansen K, Reilly G, Gardner AP, Subbiah K, Gaucher EA, Clevers H, Barnes AP.

Neural Dev. 2014 Mar 4;9:5. doi: 10.1186/1749-8104-9-5.


MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.

Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR.

EMBO J. 2003 Oct 1;22(19):5102-14.


ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.

Zeqiraj E, Filippi BM, Goldie S, Navratilova I, Boudeau J, Deak M, Alessi DR, van Aalten DM.

PLoS Biol. 2009 Jun 9;7(6):e1000126. doi: 10.1371/journal.pbio.1000126. Epub 2009 Jun 9.


STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.

Dorfman J, Macara IG.

Mol Biol Cell. 2008 Apr;19(4):1614-26. doi: 10.1091/mbc.E07-05-0454. Epub 2008 Feb 6.


Analysis of the LKB1-STRAD-MO25 complex.

Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR.

J Cell Sci. 2004 Dec 15;117(Pt 26):6365-75. Epub 2004 Nov 23.


Insights into the structural dynamics of Liver kinase B1 (LKB1) by the binding of STe20 Related Adapterα (STRADα) and Mouse protein 25α (MO25α) co-activators.

Rungsung I, Ramaswamy A.

J Biomol Struct Dyn. 2017 Apr;35(5):1138-1152. doi: 10.1080/07391102.2016.1173593. Epub 2016 Jul 8.


LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.

Barnes AP, Lilley BN, Pan YA, Plummer LJ, Powell AW, Raines AN, Sanes JR, Polleux F.

Cell. 2007 May 4;129(3):549-63.


Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization.

Marignani PA, Scott KD, Bagnulo R, Cannone D, Ferrari E, Stella A, Guanti G, Simone C, Resta N.

Cancer Biol Ther. 2007 Oct;6(10):1627-31. Epub 2007 Jul 24.


LKB1/STRAD promotes axon initiation during neuronal polarization.

Shelly M, Cancedda L, Heilshorn S, Sumbre G, Poo MM.

Cell. 2007 May 4;129(3):565-77.


Characterization of the liver kinase B1-mouse protein-25 -Ste-20-related adaptor protein complex in adult mouse skeletal muscle.

Smith CD, Compton RA, Bowler JS, Kemp JT, Sudweeks SN, Thomson DM, Winder WW.

J Appl Physiol (1985). 2011 Dec;111(6):1622-8. doi: 10.1152/japplphysiol.00160.2011. Epub 2011 Sep 8.


Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.

Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC.

EMBO J. 2003 Jun 16;22(12):3062-72.


C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization.

Kim JS, Hung W, Narbonne P, Roy R, Zhen M.

Development. 2010 Jan;137(1):93-102. doi: 10.1242/dev.041459.


STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice.

Orlova KA, Parker WE, Heuer GG, Tsai V, Yoon J, Baybis M, Fenning RS, Strauss K, Crino PB.

J Clin Invest. 2010 May;120(5):1591-602. doi: 10.1172/JCI41592. Epub 2010 Apr 26.


STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells.

Eggers CM, Kline ER, Zhong D, Zhou W, Marcus AI.

J Biol Chem. 2012 May 25;287(22):18758-68. doi: 10.1074/jbc.M111.316422. Epub 2012 Apr 6.


Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.

Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM.

Science. 2009 Dec 18;326(5960):1707-11. doi: 10.1126/science.1178377. Epub 2009 Nov 5.


Effects of 3-phosphoglycerate and other metabolites on the activation of AMP-activated protein kinase by LKB1-STRAD-MO25.

Ellingson WJ, Chesser DG, Winder WW.

Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E400-7. Epub 2006 Sep 19.


Allosteric protein kinase regulation by pseudokinases: insights from STRAD.

Rajakulendran T, Sicheri F.

Sci Signal. 2010 Mar 2;3(111):pe8. doi: 10.1126/scisignal.3111pe8. Review.


Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex.

Neumann D, Suter M, Tuerk R, Riek U, Wallimann T.

Mol Biotechnol. 2007 Jul;36(3):220-31.


Regulation of LKB1/STRAD localization and function by E-cadherin.

Sebbagh M, Santoni MJ, Hall B, Borg JP, Schwartz MA.

Curr Biol. 2009 Jan 13;19(1):37-42. doi: 10.1016/j.cub.2008.11.033. Epub 2008 Dec 24.


Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.

ten Klooster JP, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, Colland F, de Koning J, Maurice MM, Hornbeck P, Clevers H.

Dev Cell. 2009 Apr;16(4):551-62. doi: 10.1016/j.devcel.2009.01.016.

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