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Items: 1 to 20 of 100

1.

Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain.

Liao J, Wu CX, Burlak C, Zhang S, Sahm H, Wang M, Zhang ZY, Vogel KW, Federici M, Riddle SM, Nichols RJ, Liu D, Cookson MR, Stone TA, Hoang QQ.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4055-60. doi: 10.1073/pnas.1323285111. Epub 2014 Mar 3.

2.

GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2.

Biosa A, Trancikova A, Civiero L, Glauser L, Bubacco L, Greggio E, Moore DJ.

Hum Mol Genet. 2013 Mar 15;22(6):1140-56. doi: 10.1093/hmg/dds522. Epub 2012 Dec 13.

PMID:
23241358
3.

Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations.

Rudi K, Ho FY, Gilsbach BK, Pots H, Wittinghofer A, Kortholt A, Klare JP.

Biosci Rep. 2015 Aug 26;35(5). pii: e00254. doi: 10.1042/BSR20150128.

4.

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.

Deng J, Lewis PA, Greggio E, Sluch E, Beilina A, Cookson MR.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1499-504. doi: 10.1073/pnas.0709098105. Epub 2008 Jan 29.

5.

Functional properties of LRRK2 mutations in Taiwanese Parkinson disease.

Chang KH, Chen CM, Lin CH, Chang WT, Jiang PR, Hsiao YC, Wu YR, Lee-Chen GJ.

J Formos Med Assoc. 2017 Mar;116(3):197-204. doi: 10.1016/j.jfma.2016.04.009. Epub 2016 Jul 14.

6.

The GTPase function of LRRK2.

Taymans JM.

Biochem Soc Trans. 2012 Oct;40(5):1063-9. Review.

PMID:
22988866
7.

Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.

Li X, Tan YC, Poulose S, Olanow CW, Huang XY, Yue Z.

J Neurochem. 2007 Oct;103(1):238-47. Epub 2007 Jul 10.

8.

Contribution of GTPase activity to LRRK2-associated Parkinson disease.

Tsika E, Moore DJ.

Small GTPases. 2013 Jul-Sep;4(3):164-70. doi: 10.4161/sgtp.25130. Epub 2013 Jun 10. Review.

9.

Revisiting the Roco G-protein cycle.

Terheyden S, Ho FY, Gilsbach BK, Wittinghofer A, Kortholt A.

Biochem J. 2015 Jan 1;465(1):139-47. doi: 10.1042/BJ20141095.

PMID:
25317655
10.

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities.

Webber PJ, Smith AD, Sen S, Renfrow MB, Mobley JA, West AB.

J Mol Biol. 2011 Sep 9;412(1):94-110. doi: 10.1016/j.jmb.2011.07.033. Epub 2011 Jul 22.

11.

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity.

Gloeckner CJ, Kinkl N, Schumacher A, Braun RJ, O'Neill E, Meitinger T, Kolch W, Prokisch H, Ueffing M.

Hum Mol Genet. 2006 Jan 15;15(2):223-32. Epub 2005 Dec 1.

PMID:
16321986
12.

The R1441C mutation of LRRK2 disrupts GTP hydrolysis.

Lewis PA, Greggio E, Beilina A, Jain S, Baker A, Cookson MR.

Biochem Biophys Res Commun. 2007 Jun 8;357(3):668-71. Epub 2007 Apr 10.

13.

The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity.

Guo L, Gandhi PN, Wang W, Petersen RB, Wilson-Delfosse AL, Chen SG.

Exp Cell Res. 2007 Oct 1;313(16):3658-70. Epub 2007 Jul 19.

14.

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.

Greggio E, Taymans JM, Zhen EY, Ryder J, Vancraenenbroeck R, Beilina A, Sun P, Deng J, Jaffe H, Baekelandt V, Merchant K, Cookson MR.

Biochem Biophys Res Commun. 2009 Nov 20;389(3):449-54. doi: 10.1016/j.bbrc.2009.08.163. Epub 2009 Sep 3.

15.

The Parkinson disease gene LRRK2: evolutionary and structural insights.

MarĂ­n I.

Mol Biol Evol. 2006 Dec;23(12):2423-33. Epub 2006 Sep 11.

PMID:
16966681
16.

LRRK2 autophosphorylation enhances its GTPase activity.

Liu Z, Mobley JA, DeLucas LJ, Kahn RA, West AB.

FASEB J. 2016 Jan;30(1):336-47. doi: 10.1096/fj.15-277095. Epub 2015 Sep 22.

17.

L'RRK de Triomphe: a solution for LRRK2 GTPase activity?

Nixon-Abell J, Berwick DC, Harvey K.

Biochem Soc Trans. 2016 Dec 15;44(6):1625-1634. Review.

PMID:
27913671
18.

Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics.

Wu CX, Liao J, Park Y, Reed X, Engel VA, Hoang NC, Takagi Y, Johnson SM, Wang M, Federici M, Nichols RJ, Sanishvili R, Cookson MR, Hoang QQ.

J Biol Chem. 2019 Apr 12;294(15):5907-5913. doi: 10.1074/jbc.RA119.007631. Epub 2019 Feb 22.

PMID:
30796162
19.

Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.

Nguyen AP, Moore DJ.

Adv Neurobiol. 2017;14:71-88. doi: 10.1007/978-3-319-49969-7_4. Review.

20.

The R1441C mutation alters the folding properties of the ROC domain of LRRK2.

Li Y, Dunn L, Greggio E, Krumm B, Jackson GS, Cookson MR, Lewis PA, Deng J.

Biochim Biophys Acta. 2009 Dec;1792(12):1194-7. doi: 10.1016/j.bbadis.2009.09.010. Epub 2009 Sep 23.

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