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Items: 1 to 20 of 122

1.

Haloemodin as novel antibacterial agent inhibiting DNA gyrase and bacterial topoisomerase I.

Duan F, Li X, Cai S, Xin G, Wang Y, Du D, He S, Huang B, Guo X, Zhao H, Zhang R, Ma L, Liu Y, Du Q, Wei Z, Xing Z, Liang Y, Wu X, Fan C, Ji C, Zeng D, Chen Q, He Y, Liu X, Huang W.

J Med Chem. 2014 May 8;57(9):3707-14. doi: 10.1021/jm401685f.

PMID:
24588790
2.

Structure activity relationship of C-2 ether substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-5).

Singh SB, Kaelin DE, Meinke PT, Wu J, Miesel L, Tan CM, Olsen DB, Lagrutta A, Fukuda H, Kishii R, Takei M, Takeuchi T, Takano H, Ohata K, Kurasaki H, Nishimura A, Shibata T, Fukuda Y.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3630-5. doi: 10.1016/j.bmcl.2015.06.061.

PMID:
26152426
3.

Novel compounds targeting bacterial DNA topoisomerase/DNA gyrase.

Ehmann DE, Lahiri SD.

Curr Opin Pharmacol. 2014 Oct;18:76-83. doi: 10.1016/j.coph.2014.09.007. Review.

4.

Action mechanism of 6, 6'-dihydroxythiobinupharidine from Nuphar japonicum, which showed anti-MRSA and anti-VRE activities.

Okamura S, Nishiyama E, Yamazaki T, Otsuka N, Taniguchi S, Ogawa W, Hatano T, Tsuchiya T, Kuroda T.

Biochim Biophys Acta. 2015 Jun;1850(6):1245-52. doi: 10.1016/j.bbagen.2015.02.012.

PMID:
25731981
5.

Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents.

Tari LW, Li X, Trzoss M, Bensen DC, Chen Z, Lam T, Zhang J, Lee SJ, Hough G, Phillipson D, Akers-Rodriguez S, Cunningham ML, Kwan BP, Nelson KJ, Castellano A, Locke JB, Brown-Driver V, Murphy TM, Ong VS, Pillar CM, Shinabarger DL, Nix J, Lightstone FC, Wong SE, Nguyen TB, Shaw KJ, Finn J.

PLoS One. 2013 Dec 26;8(12):e84409. doi: 10.1371/journal.pone.0084409.

6.

Small molecular antibacterial peptoid mimics: the simpler the better!

Ghosh C, Manjunath GB, Akkapeddi P, Yarlagadda V, Hoque J, Uppu DS, Konai MM, Haldar J.

J Med Chem. 2014 Feb 27;57(4):1428-36. doi: 10.1021/jm401680a.

PMID:
24479371
7.

Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents.

Basarab GS, Manchester JI, Bist S, Boriack-Sjodin PA, Dangel B, Illingworth R, Sherer BA, Sriram S, Uria-Nickelsen M, Eakin AE.

J Med Chem. 2013 Nov 14;56(21):8712-35. doi: 10.1021/jm401208b.

PMID:
24098982
8.

Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents.

Hossion AM, Zamami Y, Kandahary RK, Tsuchiya T, Ogawa W, Iwado A, Sasaki K.

J Med Chem. 2011 Jun 9;54(11):3686-703. doi: 10.1021/jm200010x.

PMID:
21534606
9.

Antimicrobial activity of the pleuromutilin antibiotic BC-3781 against bacterial pathogens isolated in the SENTRY antimicrobial surveillance program in 2010.

Paukner S, Sader HS, Ivezic-Schoenfeld Z, Jones RN.

Antimicrob Agents Chemother. 2013 Sep;57(9):4489-95. doi: 10.1128/AAC.00358-13.

10.

Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.

Surivet JP, Zumbrunn C, Rueedi G, Hubschwerlen C, Bur D, Bruyère T, Locher H, Ritz D, Keck W, Seiler P, Kohl C, Gauvin JC, Mirre A, Kaegi V, Dos Santos M, Gaertner M, Delers J, Enderlin-Paput M, Boehme M.

J Med Chem. 2013 Sep 26;56(18):7396-415. doi: 10.1021/jm400963y.

PMID:
23968485
11.

Antibacterial efficacy of nisin against multidrug-resistant Gram-positive pathogens.

Severina E, Severin A, Tomasz A.

J Antimicrob Chemother. 1998 Mar;41(3):341-7.

12.

Design and synthesis of benzenesulfonanilides active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus.

Namba K, Zheng X, Motoshima K, Kobayashi H, Tai A, Takahashi E, Sasaki K, Okamoto K, Kakuta H.

Bioorg Med Chem. 2008 Jun 1;16(11):6131-44. doi: 10.1016/j.bmc.2008.04.040.

PMID:
18468909
13.

Novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram positive activity and improved safety profile.

Surivet JP, Zumbrunn C, Rueedi G, Bur D, Bruyère T, Locher H, Ritz D, Seiler P, Kohl C, Ertel EA, Hess P, Gauvin JC, Mirre A, Kaegi V, Dos Santos M, Kraemer S, Gaertner M, Delers J, Enderlin-Paput M, Weiss M, Sube R, Hadana H, Keck W, Hubschwerlen C.

J Med Chem. 2015 Jan 22;58(2):927-42. doi: 10.1021/jm501590q.

PMID:
25494934
14.

Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.

Sanabria-Ríos DJ, Rivera-Torres Y, Rosario J, Gutierrez R, Torres-García Y, Montano N, Ortíz-Soto G, Ríos-Olivares E, Rodríguez JW, Carballeira NM.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5067-71. doi: 10.1016/j.bmcl.2015.10.022.

16.

Synthesis, anti-MRSA, and anti-VRE activity of hemin conjugates with amino acids and branched peptides.

Okorochenkov SA, Zheltukhina GA, Mirchink EP, Isakova EB, Feofanov AV, Nebolsin VE.

Chem Biol Drug Des. 2013 Oct;82(4):410-7. doi: 10.1111/cbdd.12163.

PMID:
23663365
17.
18.

Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: pharmacophore identification based on the screening hit closantel.

Hlasta DJ, Demers JP, Foleno BD, Fraga-Spano SA, Guan J, Hilliard JJ, Macielag MJ, Ohemeng KA, Sheppard CM, Sui Z, Webb GC, Weidner-Wells MA, Werblood H, Barrett JF.

Bioorg Med Chem Lett. 1998 Jul 21;8(14):1923-8.

PMID:
9873460
19.

Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors.

Zhang J, Yang Q, Cross JB, Romero JA, Poutsiaka KM, Epie F, Bevan D, Wang B, Zhang Y, Chavan A, Zhang X, Moy T, Daniel A, Nguyen K, Chamberlain B, Carter N, Shotwell J, Silverman J, Metcalf CA 3rd, Ryan D, Lippa B, Dolle RE.

J Med Chem. 2015 Nov 12;58(21):8503-12. doi: 10.1021/acs.jmedchem.5b00961.

PMID:
26460684
20.

In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class.

Mani N, Gross CH, Parsons JD, Hanzelka B, Müh U, Mullin S, Liao Y, Grillot AL, Stamos D, Charifson PS, Grossman TH.

Antimicrob Agents Chemother. 2006 Apr;50(4):1228-37.

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