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Items: 1 to 20 of 105

1.

Involvement of myeloperoxidase and NADPH oxidase in the covalent binding of amodiaquine and clozapine to neutrophils: implications for drug-induced agranulocytosis.

Lobach AR, Uetrecht J.

Chem Res Toxicol. 2014 Apr 21;27(4):699-709. doi: 10.1021/tx500019u. Epub 2014 Mar 17.

PMID:
24588327
2.

The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man.

Maggs JL, Williams D, Pirmohamed M, Park BK.

J Pharmacol Exp Ther. 1995 Dec;275(3):1463-75.

PMID:
8531117
3.
4.
5.

Myeloperoxidase as a generator of drug free radicals.

Uetrecht JP.

Biochem Soc Symp. 1995;61:163-70. Review.

PMID:
8660393
6.

A comparison of the covalent binding of clozapine and olanzapine to human neutrophils in vitro and in vivo.

Gardner I, Leeder JS, Chin T, Zahid N, Uetrecht JP.

Mol Pharmacol. 1998 Jun;53(6):999-1008.

8.

Metabolism of clozapine by human neutrophils: evidence for a specific oxidation of clozapine by the myeloperoxidase system with inhibition of enzymatic chlorination cycle.

Frimat B, Gressier B, Odou P, Brunet C, Dine T, Luycky M, Cazin M, Cazin JC.

Fundam Clin Pharmacol. 1997;11(3):267-74.

PMID:
9243259
9.

Metabolism of vesnarinone by activated neutrophils: implications for vesnarinone-induced agranulocytosis.

Uetrecht JP, Zahid N, Whitfield D.

J Pharmacol Exp Ther. 1994 Sep;270(3):865-72.

PMID:
7932198
10.

Impact of myeloperoxidase and NADPH-oxidase polymorphisms in drug-induced agranulocytosis.

Mosyagin I, Dettling M, Roots I, Mueller-Oerlinghausen B, Cascorbi I.

J Clin Psychopharmacol. 2004 Dec;24(6):613-7.

PMID:
15538122
11.

Myeloperoxidase accumulates at the neutrophil surface and enhances cell metabolism and oxidant release during pregnancy.

Kindzelskii AL, Clark AJ, Espinoza J, Maeda N, Aratani Y, Romero R, Petty HR.

Eur J Immunol. 2006 Jun;36(6):1619-28.

12.
13.

Testing the hypothesis that selenium deficiency is a risk factor for clozapine-induced agranulocytosis in rats.

Ip J, Uetrecht JP.

Chem Res Toxicol. 2008 Apr;21(4):874-8. doi: 10.1021/tx7004037. Epub 2008 Apr 2.

PMID:
18380444
14.

Cigarette smoke impairs neutrophil respiratory burst activation by aldehyde-induced thiol modifications.

Nguyen H, Finkelstein E, Reznick A, Cross C, van der Vliet A.

Toxicology. 2001 Mar 7;160(1-3):207-17.

PMID:
11246141
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16.

Relative contributions of myeloperoxidase and NADPH-oxidase to the early host defense against pulmonary infections with Candida albicans and Aspergillus fumigatus.

Aratani Y, Kura F, Watanabe H, Akagawa H, Takano Y, Suzuki K, Dinauer MC, Maeda N, Koyama H.

Med Mycol. 2002 Dec;40(6):557-63.

PMID:
12521119
17.

The cytotoxicity of clozapine metabolites: implications for predicting clozapine-induced agranulocytosis.

Tschen AC, Rieder MJ, Oyewumi LK, Freeman DJ.

Clin Pharmacol Ther. 1999 May;65(5):526-32.

PMID:
10340918
18.
19.

Structural features associated with reactive metabolite formation in clozapine analogues.

Uetrecht J, Zahid N, Tehim A, Fu JM, Rakhit S.

Chem Biol Interact. 1997 May 2;104(2-3):117-29.

PMID:
9212779
20.

Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis.

Gukovskaya AS, Vaquero E, Zaninovic V, Gorelick FS, Lusis AJ, Brennan ML, Holland S, Pandol SJ.

Gastroenterology. 2002 Apr;122(4):974-84.

PMID:
11910350

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