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Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice.

Azevedo OG, Bolick DT, Roche JK, Pinkerton RF, Lima AA, Vitek MP, Warren CA, Oriá RB, Guerrant RL.

PLoS One. 2014 Feb 28;9(2):e89562. doi: 10.1371/journal.pone.0089562. eCollection 2014.


Arginine decreases Cryptosporidium parvum infection in undernourished suckling mice involving nitric oxide synthase and arginase.

Castro IC, Oliveira BB, Slowikowski JJ, Coutinho BP, Siqueira FJ, Costa LB, Sevilleja JE, Almeida CA, Lima AA, Warren CA, Oriá RB, Guerrant RL.

Nutrition. 2012 Jun;28(6):678-85. doi: 10.1016/j.nut.2011.09.011. Epub 2012 Jan 20.


Cryptosporidium-malnutrition interactions: mucosal disruption, cytokines, and TLR signaling in a weaned murine model.

Costa LB, JohnBull EA, Reeves JT, Sevilleja JE, Freire RS, Hoffman PS, Lima AA, Oriá RB, Roche JK, Guerrant RL, Warren CA.

J Parasitol. 2011 Dec;97(6):1113-20. doi: 10.1645/GE-2848.1. Epub 2011 Jun 28.


Apolipoprotein E isoform mediated regulation of nitric oxide release.

Brown CM, Wright E, Colton CA, Sullivan PM, Laskowitz DT, Vitek MP.

Free Radic Biol Med. 2002 Jun 1;32(11):1071-5.


Apolipoprotein E4 decreases whereas apolipoprotein E3 increases the level of secreted amyloid precursor protein after closed head injury.

Ezra Y, Oron L, Moskovich L, Roses AD, Beni SM, Shohami E, Michaelson DM.

Neuroscience. 2003;121(2):315-25.


APOE genotype-specific differences in the innate immune response.

Vitek MP, Brown CM, Colton CA.

Neurobiol Aging. 2009 Sep;30(9):1350-60. Epub 2007 Dec 21.


Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks.

Bour A, Grootendorst J, Vogel E, Kelche C, Dodart JC, Bales K, Moreau PH, Sullivan PM, Mathis C.

Behav Brain Res. 2008 Nov 21;193(2):174-82. doi: 10.1016/j.bbr.2008.05.008. Epub 2008 May 18.


Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior.

Grootendorst J, Bour A, Vogel E, Kelche C, Sullivan PM, Dodart JC, Bales K, Mathis C.

Behav Brain Res. 2005 Apr 15;159(1):1-14. Epub 2004 Nov 6.


Cryptosporidium infection causes undernutrition and, conversely, weanling undernutrition intensifies infection.

Coutinho BP, Oriá RB, Vieira CM, Sevilleja JE, Warren CA, Maciel JG, Thompson MR, Pinkerton RC, Lima AA, Guerrant RL.

J Parasitol. 2008 Dec;94(6):1225-32. doi: 10.1645/GE-1411.1.


Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y.

J Neurosci. 2004 Mar 10;24(10):2527-34.


APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress.

Colton CA, Brown CM, Cook D, Needham LK, Xu Q, Czapiga M, Saunders AM, Schmechel DE, Rasheed K, Vitek MP.

Neurobiol Aging. 2002 Sep-Oct;23(5):777-85.


Effect of human apolipoprotein E genotype on the pathogenesis of experimental ocular HSV-1.

Bhattacharjee PS, Neumann DM, Foster TP, Bouhanik S, Clement C, Vinay D, Thompson HW, Hill JM.

Exp Eye Res. 2008 Aug;87(2):122-30. doi: 10.1016/j.exer.2008.05.007. Epub 2008 May 18.


Effect of domain interaction on apolipoprotein E levels in mouse brain.

Ramaswamy G, Xu Q, Huang Y, Weisgraber KH.

J Neurosci. 2005 Nov 16;25(46):10658-63.


Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E.

Raffai RL, Dong LM, Farese RV Jr, Weisgraber KH.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11587-91. Epub 2001 Sep 11.


Evidence for differential effects of apoE3 and apoE4 on HDL metabolism.

Hopkins PC, Huang Y, McGuire JG, Pitas RE.

J Lipid Res. 2002 Nov;43(11):1881-9.


Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice.

Ophir G, Meilin S, Efrati M, Chapman J, Karussis D, Roses A, Michaelson DM.

Neurobiol Dis. 2003 Feb;12(1):56-64.


ApoE isoform affects LTP in human targeted replacement mice.

Trommer BL, Shah C, Yun SH, Gamkrelidze G, Pasternak ES, Ye GL, Sotak M, Sullivan PM, Pasternak JF, LaDu MJ.

Neuroreport. 2004 Dec 3;15(17):2655-8.


Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2.

Klein RC, Mace BE, Moore SD, Sullivan PM.

Neuroscience. 2010 Dec 29;171(4):1265-72. doi: 10.1016/j.neuroscience.2010.10.027. Epub 2010 Oct 15.

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