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Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylation.

Sanz-Moreno A, Fuhrmann D, Wolf E, von Eyss B, Eilers M, Elsässer HP.

PLoS One. 2014 Feb 19;9(2):e89187. doi: 10.1371/journal.pone.0089187. eCollection 2014.


Zinc Finger Homeodomain Factor Zfhx3 Is Essential for Mammary Lactogenic Differentiation by Maintaining Prolactin Signaling Activity.

Zhao D, Ma G, Zhang X, He Y, Li M, Han X, Fu L, Dong XY, Nagy T, Zhao Q, Fu L, Dong JT.

J Biol Chem. 2016 Jun 10;291(24):12809-20. doi: 10.1074/jbc.M116.719377. Epub 2016 Apr 20.


Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways.

Chen CC, Stairs DB, Boxer RB, Belka GK, Horseman ND, Alvarez JV, Chodosh LA.

Genes Dev. 2012 Oct 1;26(19):2154-68. doi: 10.1101/gad.197343.112.


Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation.

Ke Y, Lesperance J, Zhang EE, Bard-Chapeau EA, Oshima RG, Muller WJ, Feng GS.

J Biol Chem. 2006 Nov 10;281(45):34374-80. Epub 2006 Sep 7.


Miz1 is a critical repressor of cdkn1a during skin tumorigenesis.

Hönnemann J, Sanz-Moreno A, Wolf E, Eilers M, Elsässer HP.

PLoS One. 2012;7(4):e34885. doi: 10.1371/journal.pone.0034885. Epub 2012 Apr 11.


Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration.

Yamaji D, Kang K, Robinson GW, Hennighausen L.

Nucleic Acids Res. 2013 Feb 1;41(3):1622-36. doi: 10.1093/nar/gks1310. Epub 2012 Dec 28.


Regulation of mammary gland factor/Stat5a during mammary gland development.

Kazansky AV, Raught B, Lindsey SM, Wang YF, Rosen JM.

Mol Endocrinol. 1995 Nov;9(11):1598-609.


The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development.

Clarkson RW, Boland MP, Kritikou EA, Lee JM, Freeman TC, Tiffen PG, Watson CJ.

Mol Endocrinol. 2006 Mar;20(3):675-85. Epub 2005 Nov 17.


Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects.

Gallego MI, Binart N, Robinson GW, Okagaki R, Coschigano KT, Perry J, Kopchick JJ, Oka T, Kelly PA, Hennighausen L.

Dev Biol. 2001 Jan 1;229(1):163-75.


Late onset neuropathy with spontaneous clinical remission in mice lacking the POZ domain of the transcription factor Myc-interacting zinc finger protein 1 (Miz1) in Schwann cells.

Sanz-Moreno A, Fuhrmann D, Zankel A, Reingruber H, Kern L, Meijer D, Niemann A, Elsässer HP.

J Biol Chem. 2015 Jan 9;290(2):727-43. doi: 10.1074/jbc.M114.605931. Epub 2014 Nov 21. Erratum in: J Biol Chem. 2015 Jul 24;290(30):18478.


Akt is required for Stat5 activation and mammary differentiation.

Chen CC, Boxer RB, Stairs DB, Portocarrero CP, Horton RH, Alvarez JV, Birnbaum MJ, Chodosh LA.

Breast Cancer Res. 2010;12(5):R72. doi: 10.1186/bcr2640. Epub 2010 Sep 17.


Lactation failure in Src knockout mice is due to impaired secretory activation.

Watkin H, Richert MM, Lewis A, Terrell K, McManaman JP, Anderson SM.

BMC Dev Biol. 2008 Jan 23;8:6. doi: 10.1186/1471-213X-8-6.


Targeted expression of GLI1 in the mammary gland disrupts pregnancy-induced maturation and causes lactation failure.

Fiaschi M, Rozell B, Bergström A, Toftgård R, Kleman MI.

J Biol Chem. 2007 Dec 7;282(49):36090-101. Epub 2007 Oct 10.


Conditional repression of STAT5 expression during lactation reveals its exclusive roles in mammary gland morphology, milk-protein gene expression, and neonate growth.

Reichenstein M, Rauner G, Barash I.

Mol Reprod Dev. 2011 Aug;78(8):585-96. doi: 10.1002/mrd.21345. Epub 2011 Jun 17.


Prolactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cells.

Qian L, Lopez V, Seo YA, Kelleher SL.

Am J Physiol Cell Physiol. 2009 Aug;297(2):C369-77. doi: 10.1152/ajpcell.00589.2008. Epub 2009 Jun 3.


Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis.

Schmidt JW, Wehde BL, Sakamoto K, Triplett AA, Anderson SM, Tsichlis PN, Leone G, Wagner KU.

Mol Cell Biol. 2014 Apr;34(7):1363-77. doi: 10.1128/MCB.01220-13. Epub 2014 Jan 27.

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