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Items: 1 to 20 of 108

1.

RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis.

Chen W, Wang Q, Bai L, Chen W, Wang X, Tellez CS, Leng S, Padilla MT, Nyunoya T, Belinsky SA, Lin Y.

Cell Death Differ. 2014 Jul;21(7):1061-70. doi: 10.1038/cdd.2014.25. Epub 2014 Feb 28.

2.

Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch.

Tennakoon JB, Shi Y, Han JJ, Tsouko E, White MA, Burns AR, Zhang A, Xia X, Ilkayeva OR, Xin L, Ittmann MM, Rick FG, Schally AV, Frigo DE.

Oncogene. 2014 Nov 6;33(45):5251-61. doi: 10.1038/onc.2013.463. Epub 2013 Nov 4.

3.

Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α.

Wang Y, Zhao X, Lotz M, Terkeltaub R, Liu-Bryan R.

Arthritis Rheumatol. 2015 May;67(8):2141-53. doi: 10.1002/art.39182.

4.

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.

LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Domingos Chinen LT, Rocha RM, Asara JM, Kalluri R.

Nat Cell Biol. 2014 Oct;16(10):992-1003, 1-15. doi: 10.1038/ncb3039. Epub 2014 Sep 21. Erratum in: Nat Cell Biol. 2014 Nov;16(11):1125.

5.

The key role of PGC-1α in mitochondrial biogenesis and the proliferation of pulmonary artery vascular smooth muscle cells at an early stage of hypoxic exposure.

Rao J, Li J, Liu Y, Lu P, Sun X, Sugumaran PK, Zhu D.

Mol Cell Biochem. 2012 Aug;367(1-2):9-18. doi: 10.1007/s11010-012-1313-z. Epub 2012 Apr 15.

PMID:
22527940
6.

Characterization of the metabolic effects of irisin on skeletal muscle in vitro.

Vaughan RA, Gannon NP, Barberena MA, Garcia-Smith R, Bisoffi M, Mermier CM, Conn CA, Trujillo KA.

Diabetes Obes Metab. 2014 Aug;16(8):711-8. doi: 10.1111/dom.12268. Epub 2014 Feb 18.

PMID:
24476050
7.

Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation.

Peeters A, Shinde AB, Dirkx R, Smet J, De Bock K, Espeel M, Vanhorebeek I, Vanlander A, Van Coster R, Carmeliet P, Fransen M, Van Veldhoven PP, Baes M.

Biochim Biophys Acta. 2015 Feb;1853(2):285-98. doi: 10.1016/j.bbamcr.2014.11.017. Epub 2014 Nov 20.

9.

Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.

Liu W, Beck BH, Vaidya KS, Nash KT, Feeley KP, Ballinger SW, Pounds KM, Denning WL, Diers AR, Landar A, Dhar A, Iwakuma T, Welch DR.

Cancer Res. 2014 Feb 1;74(3):954-63. doi: 10.1158/0008-5472.CAN-13-1183. Epub 2013 Dec 18.

10.

PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons.

Wareski P, Vaarmann A, Choubey V, Safiulina D, Liiv J, Kuum M, Kaasik A.

J Biol Chem. 2009 Aug 7;284(32):21379-85. doi: 10.1074/jbc.M109.018911. Epub 2009 Jun 19.

11.
12.

The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism.

Lu J, Tan M, Cai Q.

Cancer Lett. 2015 Jan 28;356(2 Pt A):156-64. doi: 10.1016/j.canlet.2014.04.001. Epub 2014 Apr 13. Review.

13.

Peroxisome proliferator-activated-γ coactivator-1α-mediated mitochondrial biogenesis is important for hematopoietic recovery in response to stress.

Basu S, Broxmeyer HE, Hangoc G.

Stem Cells Dev. 2013 Jun 1;22(11):1678-92. doi: 10.1089/scd.2012.0466. Epub 2013 Feb 13.

14.

Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.

Buler M, Aatsinki SM, Skoumal R, Komka Z, Tóth M, Kerkelä R, Georgiadi A, Kersten S, Hakkola J.

J Biol Chem. 2012 Jan 13;287(3):1847-60. doi: 10.1074/jbc.M111.302356. Epub 2011 Nov 23.

15.

Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression.

Peeters A, Fraisl P, van den Berg S, Ver Loren van Themaat E, Van Kampen A, Rider MH, Takemori H, van Dijk KW, Van Veldhoven PP, Carmeliet P, Baes M.

J Biol Chem. 2011 Dec 9;286(49):42162-79. doi: 10.1074/jbc.M111.299727. Epub 2011 Oct 14.

16.

Mitochondrial dysfunction accounts for aldosterone-induced epithelial-to-mesenchymal transition of renal proximal tubular epithelial cells.

Yuan Y, Chen Y, Zhang P, Huang S, Zhu C, Ding G, Liu B, Yang T, Zhang A.

Free Radic Biol Med. 2012 Jul 1;53(1):30-43. doi: 10.1016/j.freeradbiomed.2012.03.015. Epub 2012 Apr 25.

PMID:
22608985
17.

Tumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition--a Warburg-reversing effect.

Lu CL, Qin L, Liu HC, Candas D, Fan M, Li JJ.

PLoS One. 2015 Mar 25;10(3):e0121046. doi: 10.1371/journal.pone.0121046. eCollection 2015.

19.

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.

Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P.

Nature. 2007 Nov 29;450(7170):736-40.

PMID:
18046414
20.

Zinc finger nuclease mediated knockout of ADP-dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism.

Richter S, Morrison S, Connor T, Su J, Print CG, Ronimus RS, McGee SL, Wilson WR.

PLoS One. 2013 Jun 14;8(6):e65267. doi: 10.1371/journal.pone.0065267. Print 2013.

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