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Items: 1 to 20 of 108

1.

Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma.

Honeyman JN, Simon EP, Robine N, Chiaroni-Clarke R, Darcy DG, Lim II, Gleason CE, Murphy JM, Rosenberg BR, Teegan L, Takacs CN, Botero S, Belote R, Germer S, Emde AK, Vacic V, Bhanot U, LaQuaglia MP, Simon SM.

Science. 2014 Feb 28;343(6174):1010-4. doi: 10.1126/science.1249484.

2.

CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1-Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma.

Engelholm LH, Riaz A, Serra D, Dagnæs-Hansen F, Johansen JV, Santoni-Rugiu E, Hansen SH, Niola F, Frödin M.

Gastroenterology. 2017 Dec;153(6):1662-1673.e10. doi: 10.1053/j.gastro.2017.09.008. Epub 2017 Sep 18.

3.

A genomic case study of mixed fibrolamellar hepatocellular carcinoma.

Griffith OL, Griffith M, Krysiak K, Magrini V, Ramu A, Skidmore ZL, Kunisaki J, Austin R, McGrath S, Zhang J, Demeter R, Graves T, Eldred JM, Walker J, Larson DE, Maher CA, Lin Y, Chapman W, Mahadevan A, Miksad R, Nasser I, Hanto DW, Mardis ER.

Ann Oncol. 2016 Jun;27(6):1148-54. doi: 10.1093/annonc/mdw135. Epub 2016 Mar 30.

4.

DNAJB1-PRKACA is specific for fibrolamellar carcinoma.

Graham RP, Jin L, Knutson DL, Kloft-Nelson SM, Greipp PT, Waldburger N, Roessler S, Longerich T, Roberts LR, Oliveira AM, Halling KC, Schirmacher P, Torbenson MS.

Mod Pathol. 2015 Jun;28(6):822-9. doi: 10.1038/modpathol.2015.4. Epub 2015 Feb 20.

5.

Fibrolamellar Hepatocellular Carcinoma: Mechanistic Distinction From Adult Hepatocellular Carcinoma.

Riggle KM, Turnham R, Scott JD, Yeung RS, Riehle KJ.

Pediatr Blood Cancer. 2016 Jul;63(7):1163-7. doi: 10.1002/pbc.25970. Epub 2016 Mar 14. Review.

6.

Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma.

Riggle KM, Riehle KJ, Kenerson HL, Turnham R, Homma MK, Kazami M, Samelson B, Bauer R, McKnight GS, Scott JD, Yeung RS.

Pediatr Res. 2016 Jul;80(1):110-8. doi: 10.1038/pr.2016.36. Epub 2016 Mar 8.

7.

The DNAJB1-PRKACA chimera: Candidate biomarker and therapeutic target for fibrolamellar carcinomas.

Reid LM, Sethupathy P.

Hepatology. 2016 Feb;63(2):662-4. doi: 10.1002/hep.28307. Epub 2015 Dec 14. No abstract available.

PMID:
26505878
8.

Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells.

Oikawa T, Wauthier E, Dinh TA, Selitsky SR, Reyna-Neyra A, Carpino G, Levine R, Cardinale V, Klimstra D, Gaudio E, Alvaro D, Carrasco N, Sethupathy P, Reid LM.

Nat Commun. 2015 Oct 6;6:8070. doi: 10.1038/ncomms9070.

9.

Unique genomic profile of fibrolamellar hepatocellular carcinoma.

Cornella H, Alsinet C, Sayols S, Zhang Z, Hao K, Cabellos L, Hoshida Y, Villanueva A, Thung S, Ward SC, Rodriguez-Carunchio L, Vila-Casadesús M, Imbeaud S, Lachenmayer A, Quaglia A, Nagorney DM, Minguez B, Carrilho F, Roberts LR, Waxman S, Mazzaferro V, Schwartz M, Esteller M, Heaton ND, Zucman-Rossi J, Llovet JM.

Gastroenterology. 2015 Apr;148(4):806-18.e10. doi: 10.1053/j.gastro.2014.12.028. Epub 2014 Dec 31.

10.

Transcriptomic characterization of fibrolamellar hepatocellular carcinoma.

Simon EP, Freije CA, Farber BA, Lalazar G, Darcy DG, Honeyman JN, Chiaroni-Clarke R, Dill BD, Molina H, Bhanot UK, La Quaglia MP, Rosenberg BR, Simon SM.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):E5916-25. doi: 10.1073/pnas.1424894112. Epub 2015 Oct 21.

11.

Advances in fibrolamellar hepatocellular carcinoma: a review.

Lim II, Farber BA, LaQuaglia MP.

Eur J Pediatr Surg. 2014 Dec;24(6):461-6. doi: 10.1055/s-0034-1396420. Epub 2014 Dec 8. Review.

PMID:
25486412
12.

FGFR1 and FGFR2 in fibrolamellar carcinoma.

Graham RP, Garcia JJ, Greipp PT, Barr Fritcher EG, Kipp BR, Torbenson MS.

Histopathology. 2016 Apr;68(5):686-92. doi: 10.1111/his.12799. Epub 2015 Oct 5.

PMID:
26259677
13.

DNAJB1-PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma.

Kastenhuber ER, Lalazar G, Houlihan SL, Tschaharganeh DF, Baslan T, Chen CC, Requena D, Tian S, Bosbach B, Wilkinson JE, Simon SM, Lowe SW.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13076-13084. doi: 10.1073/pnas.1716483114. Epub 2017 Nov 21.

PMID:
29162699
14.

Hepatic adenomas with synchronous or metachronous fibrolamellar carcinomas: both are characterized by LFABP loss.

Graham RP, Terracciano LM, Meves A, Vanderboom PM, Dasari S, Yeh MM, Torbenson MS, Cruise MW.

Mod Pathol. 2016 Jun;29(6):607-15. doi: 10.1038/modpathol.2016.59. Epub 2016 Mar 25.

15.

Genomic analysis of fibrolamellar hepatocellular carcinoma.

Xu L, Hazard FK, Zmoos AF, Jahchan N, Chaib H, Garfin PM, Rangaswami A, Snyder MP, Sage J.

Hum Mol Genet. 2015 Jan 1;24(1):50-63. doi: 10.1093/hmg/ddu418. Epub 2014 Aug 13.

16.

Fibrolamellar carcinoma: A histologically unique tumor with unique molecular findings.

Graham RP, Torbenson MS.

Semin Diagn Pathol. 2017 Mar;34(2):146-152. doi: 10.1053/j.semdp.2016.12.010. Epub 2016 Dec 23. Review.

PMID:
28110996
17.

The genomic landscape of fibrolamellar hepatocellular carcinoma: whole genome sequencing of ten patients.

Darcy DG, Chiaroni-Clarke R, Murphy JM, Honeyman JN, Bhanot U, LaQuaglia MP, Simon SM.

Oncotarget. 2015 Jan 20;6(2):755-70.

18.

Fibrolamellar carcinoma in the Carney complex: PRKAR1A loss instead of the classic DNAJB1-PRKACA fusion.

Graham RP, Lackner C, Terracciano L, González-Cantú Y, Maleszewski JJ, Greipp PT, Simon SM, Torbenson MS.

Hepatology. 2017 Dec 9. doi: 10.1002/hep.29719. [Epub ahead of print]

PMID:
29222914
19.

Environmental exposures as a risk factor for fibrolamellar carcinoma.

Graham RP, Craig JR, Jin L, Oliveira AM, Bergquist JR, Truty MJ, Mounajjed T, Greipp PT, Torbenson MS.

Mod Pathol. 2017 Jun;30(6):892-896. doi: 10.1038/modpathol.2017.7. Epub 2017 Mar 3.

PMID:
28256571
20.

Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma.

Tomasini MD, Wang Y, Karamafrooz A, Li G, Beuming T, Gao J, Taylor SS, Veglia G, Simon SM.

Sci Rep. 2018 Jan 15;8(1):720. doi: 10.1038/s41598-017-18956-w.

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