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Items: 1 to 20 of 151

1.

Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome.

Colak D, Zaninovic N, Cohen MS, Rosenwaks Z, Yang WY, Gerhardt J, Disney MD, Jaffrey SR.

Science. 2014 Feb 28;343(6174):1002-5. doi: 10.1126/science.1245831.

2.

CGG-repeat dynamics and FMR1 gene silencing in fragile X syndrome stem cells and stem cell-derived neurons.

Zhou Y, Kumari D, Sciascia N, Usdin K.

Mol Autism. 2016 Oct 6;7:42. eCollection 2016.

3.

FMR1 CGG repeat lengths mediate different regulation of reporter gene expression in comparative transient and locus specific integration assays.

Sølvsten C, Nielsen AL.

Gene. 2011 Oct 15;486(1-2):15-22. doi: 10.1016/j.gene.2011.06.034. Epub 2011 Jul 13.

PMID:
21767618
4.

Reversion of FMR1 Methylation and Silencing by Editing the Triplet Repeats in Fragile X iPSC-Derived Neurons.

Park CY, Halevy T, Lee DR, Sung JJ, Lee JS, Yanuka O, Benvenisty N, Kim DW.

Cell Rep. 2015 Oct 13;13(2):234-41. doi: 10.1016/j.celrep.2015.08.084. Epub 2015 Oct 1.

5.

Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome.

Sheridan SD, Theriault KM, Reis SA, Zhou F, Madison JM, Daheron L, Loring JF, Haggarty SJ.

PLoS One. 2011;6(10):e26203. doi: 10.1371/journal.pone.0026203. Epub 2011 Oct 12.

6.

CGG Repeat-Induced FMR1 Silencing Depends on the Expansion Size in Human iPSCs and Neurons Carrying Unmethylated Full Mutations.

Brykczynska U, Pecho-Vrieseling E, Thiemeyer A, Klein J, Fruh I, Doll T, Manneville C, Fuchs S, Iazeolla M, Beibel M, Roma G, Naumann U, Kelley N, Oakeley EJ, Mueller M, Gomez-Mancilla B, Bühler M, Tabolacci E, Chiurazzi P, Neri G, Bouwmeester T, Di Giorgio FP, Fodor BD.

Stem Cell Reports. 2016 Dec 13;7(6):1059-1071. doi: 10.1016/j.stemcr.2016.10.004. Epub 2016 Nov 10.

7.

Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.

Todd PK, Oh SY, Krans A, Pandey UB, Di Prospero NA, Min KT, Taylor JP, Paulson HL.

PLoS Genet. 2010 Dec 9;6(12):e1001240. doi: 10.1371/journal.pgen.1001240.

8.

Unstable mutations in the FMR1 gene and the phenotypes.

Loesch D, Hagerman R.

Adv Exp Med Biol. 2012;769:78-114. Review.

9.

An origin of DNA replication in the promoter region of the human fragile X mental retardation (FMR1) gene.

Gray SJ, Gerhardt J, Doerfler W, Small LE, Fanning E.

Mol Cell Biol. 2007 Jan;27(2):426-37. Epub 2006 Nov 13.

10.

Reactivation of FMR1 by CRISPR/Cas9-Mediated Deletion of the Expanded CGG-Repeat of the Fragile X Chromosome.

Xie N, Gong H, Suhl JA, Chopra P, Wang T, Warren ST.

PLoS One. 2016 Oct 21;11(10):e0165499. doi: 10.1371/journal.pone.0165499. eCollection 2016.

11.

Examination of FMR1 transcript and protein levels among 74 premutation carriers.

Peprah E, He W, Allen E, Oliver T, Boyne A, Sherman SL.

J Hum Genet. 2010 Jan;55(1):66-8. doi: 10.1038/jhg.2009.121. Epub 2009 Nov 20.

12.

CGG repeat in the FMR1 gene: size matters.

Willemsen R, Levenga J, Oostra BA.

Clin Genet. 2011 Sep;80(3):214-25. doi: 10.1111/j.1399-0004.2011.01723.x. Epub 2011 Jun 30. Review.

13.

The FMR1 promoter is selectively hydroxymethylated in primary neurons of fragile X syndrome patients.

Esanov R, Andrade NS, Bennison S, Wahlestedt C, Zeier Z.

Hum Mol Genet. 2016 Nov 15;25(22):4870-4880. doi: 10.1093/hmg/ddw311.

PMID:
28173181
14.

Nucleosomal occupancy and CGG repeat expansion: a comparative analysis of triplet repeat region from mouse and human fragile X mental retardation gene 1.

Datta S, Alam MP, Majumdar SS, Mehta AK, Maiti S, Wadhwa N, Brahmachari V.

Chromosome Res. 2011 May;19(4):445-55. doi: 10.1007/s10577-011-9206-7. Epub 2011 Apr 16.

PMID:
21499798
15.

FMR1 epigenetic silencing commonly occurs in undifferentiated fragile X-affected embryonic stem cells.

Avitzour M, Mor-Shaked H, Yanovsky-Dagan S, Aharoni S, Altarescu G, Renbaum P, Eldar-Geva T, Schonberger O, Levy-Lahad E, Epsztejn-Litman S, Eiges R.

Stem Cell Reports. 2014 Nov 11;3(5):699-706. doi: 10.1016/j.stemcr.2014.09.001. Epub 2014 Oct 3.

16.

Abnormal dendrite and spine morphology in primary visual cortex in the CGG knock-in mouse model of the fragile X premutation.

Berman RF, Murray KD, Arque G, Hunsaker MR, Wenzel HJ.

Epilepsia. 2012 Jun;53 Suppl 1:150-60. doi: 10.1111/j.1528-1167.2012.03486.x.

17.

Elevated Fmr1 mRNA levels and reduced protein expression in a mouse model with an unmethylated Fragile X full mutation.

Brouwer JR, Mientjes EJ, Bakker CE, Nieuwenhuizen IM, Severijnen LA, Van der Linde HC, Nelson DL, Oostra BA, Willemsen R.

Exp Cell Res. 2007 Jan 15;313(2):244-53. Epub 2006 Oct 13.

18.

[Chromatin changes caused by CGG repeat expansion in fmr1 gene].

Yudkin DV, Lemskaya NA, Grischenko IV, Dolskiy AA.

Mol Biol (Mosk). 2015 Mar-Apr;49(2):205-11. Review. Russian.

19.

Cerebral protein synthesis in a knockin mouse model of the fragile X premutation.

Qin M, Huang T, Liu Z, Kader M, Burlin T, Xia Z, Zeidler Z, Hukema RK, Smith CB.

ASN Neuro. 2014 Sep 23;6(5). pii: 1759091414551957. doi: 10.1177/1759091414551957. Print 2014.

20.

Instability of a (CGG)98 repeat in the Fmr1 promoter.

Bontekoe CJ, Bakker CE, Nieuwenhuizen IM, van der Linde H, Lans H, de Lange D, Hirst MC, Oostra BA.

Hum Mol Genet. 2001 Aug 1;10(16):1693-9.

PMID:
11487573

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