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Items: 1 to 20 of 390

1.

Akt and mTOR mediate programmed necrosis in neurons.

Liu Q, Qiu J, Liang M, Golinski J, van Leyen K, Jung JE, You Z, Lo EH, Degterev A, Whalen MJ.

Cell Death Dis. 2014 Feb 27;5:e1084. doi: 10.1038/cddis.2014.69.

2.

Critical contribution of oxidative stress to TNFα-induced necroptosis downstream of RIPK1 activation.

Shindo R, Kakehashi H, Okumura K, Kumagai Y, Nakano H.

Biochem Biophys Res Commun. 2013 Jun 28;436(2):212-6. doi: 10.1016/j.bbrc.2013.05.075. Epub 2013 May 29.

PMID:
23727581
3.

RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis.

Kearney CJ, Cullen SP, Clancy D, Martin SJ.

FEBS J. 2014 Nov;281(21):4921-34. doi: 10.1111/febs.13034. Epub 2014 Oct 4.

4.

The mechanistic target of rapamycin (mTOR) pathway and S6 Kinase mediate diazoxide preconditioning in primary rat cortical neurons.

Dutta S, Rutkai I, Katakam PV, Busija DW.

J Neurochem. 2015 Sep;134(5):845-56. doi: 10.1111/jnc.13181. Epub 2015 Jul 1.

5.

Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis.

Kim DI, Lee KH, Gabr AA, Choi GE, Kim JS, Ko SH, Han HJ.

Biochim Biophys Acta. 2016 Nov;1863(11):2820-2834. doi: 10.1016/j.bbamcr.2016.09.003. Epub 2016 Sep 4.

PMID:
27599716
6.

Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis.

Zhou Q, Liu C, Liu W, Zhang H, Zhang R, Liu J, Zhang J, Xu C, Liu L, Huang S, Chen L.

Toxicol Sci. 2015 Jan;143(1):81-96. doi: 10.1093/toxsci/kfu211. Epub 2014 Oct 9.

7.

Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.

McNamara CR, Ahuja R, Osafo-Addo AD, Barrows D, Kettenbach A, Skidan I, Teng X, Cuny GD, Gerber S, Degterev A.

PLoS One. 2013;8(3):e56576. doi: 10.1371/journal.pone.0056576. Epub 2013 Mar 1.

8.

Smac mimetic triggers necroptosis in pancreatic carcinoma cells when caspase activation is blocked.

Hannes S, Abhari BA, Fulda S.

Cancer Lett. 2016 Sep 28;380(1):31-8. doi: 10.1016/j.canlet.2016.05.036. Epub 2016 Jun 3.

PMID:
27267809
9.

GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways.

Vigneron F, Dos Santos P, Lemoine S, Bonnet M, Tariosse L, Couffinhal T, Duplaà C, Jaspard-Vinassa B.

Cardiovasc Res. 2011 Apr 1;90(1):49-56. doi: 10.1093/cvr/cvr002. Epub 2011 Jan 13.

PMID:
21233250
10.

RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis.

Orozco S, Yatim N, Werner MR, Tran H, Gunja SY, Tait SW, Albert ML, Green DR, Oberst A.

Cell Death Differ. 2014 Oct;21(10):1511-21. doi: 10.1038/cdd.2014.76. Epub 2014 Jun 6.

11.

PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosis.

Akundi RS, Zhi L, Büeler H.

Neurobiol Dis. 2012 Jan;45(1):469-78. doi: 10.1016/j.nbd.2011.08.034. Epub 2011 Sep 16.

12.

Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia.

Kim SJ, Li J.

Cell Death Dis. 2013 Jul 11;4:e716. doi: 10.1038/cddis.2013.238.

13.

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition.

Dondelinger Y, Aguileta MA, Goossens V, Dubuisson C, Grootjans S, Dejardin E, Vandenabeele P, Bertrand MJ.

Cell Death Differ. 2013 Oct;20(10):1381-92. doi: 10.1038/cdd.2013.94. Epub 2013 Jul 26.

14.

Inhibition of Receptor Interacting Protein Kinases Attenuates Cardiomyocyte Hypertrophy Induced by Palmitic Acid.

Zhao M, Lu L, Lei S, Chai H, Wu S, Tang X, Bao Q, Chen L, Wu W, Liu X.

Oxid Med Cell Longev. 2016;2016:1451676. doi: 10.1155/2016/1451676. Epub 2016 Jan 4.

15.

Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathways.

Jin Y, Sui HJ, Dong Y, Ding Q, Qu WH, Yu SX, Jin YX.

Acta Pharmacol Sin. 2012 Jul;33(7):861-72. doi: 10.1038/aps.2012.59. Epub 2012 Jun 18.

16.

Differential modulation of Akt/glycogen synthase kinase-3beta pathway regulates apoptotic and cytoprotective signaling responses.

Nair VD, Olanow CW.

J Biol Chem. 2008 May 30;283(22):15469-78. doi: 10.1074/jbc.M707238200. Epub 2008 Apr 3.

17.

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation.

Jouan-Lanhouet S, Arshad MI, Piquet-Pellorce C, Martin-Chouly C, Le Moigne-Muller G, Van Herreweghe F, Takahashi N, Sergent O, Lagadic-Gossmann D, Vandenabeele P, Samson M, Dimanche-Boitrel MT.

Cell Death Differ. 2012 Dec;19(12):2003-14. doi: 10.1038/cdd.2012.90. Epub 2012 Jul 20.

18.

Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells.

Edelstein J, Hao T, Cao Q, Morales L, Rockwell P.

Cell Signal. 2011 Jan;23(1):239-48. doi: 10.1016/j.cellsig.2010.09.008. Epub 2010 Sep 16.

20.

Distinctive roles of receptor-interacting protein kinases 1 and 3 in caspase-independent cell death of L929.

Park SY, Shim JH, Cho YS.

Cell Biochem Funct. 2014 Jan;32(1):62-9. doi: 10.1002/cbf.2972. Epub 2013 Apr 15.

PMID:
23584955

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