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Items: 1 to 20 of 97


G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection.

Scognamiglio PL, Di Natale C, Leone M, Poletto M, Vitagliano L, Tell G, Marasco D.

Biochim Biophys Acta. 2014 Jun;1840(6):2050-9. doi: 10.1016/j.bbagen.2014.02.017. Epub 2014 Feb 24.


Synergic role of nucleophosmin three-helix bundle and a flanking unstructured tail in the interaction with G-quadruplex DNA.

Arcovito A, Chiarella S, Della Longa S, Di Matteo A, Lo Sterzo C, Scaglione GL, Federici L.

J Biol Chem. 2014 Aug 1;289(31):21230-41. doi: 10.1074/jbc.M114.565010. Epub 2014 Jun 21.


Structure of nucleophosmin DNA-binding domain and analysis of its complex with a G-quadruplex sequence from the c-MYC promoter.

Gallo A, Lo Sterzo C, Mori M, Di Matteo A, Bertini I, Banci L, Brunori M, Federici L.

J Biol Chem. 2012 Aug 3;287(32):26539-48. doi: 10.1074/jbc.M112.371013. Epub 2012 Jun 15.


Nucleophosmin C-terminal leukemia-associated domain interacts with G-rich quadruplex forming DNA.

Federici L, Arcovito A, Scaglione GL, Scaloni F, Lo Sterzo C, Di Matteo A, Falini B, Giardina B, Brunori M.

J Biol Chem. 2010 Nov 26;285(48):37138-49. doi: 10.1074/jbc.M110.166736. Epub 2010 Sep 20.


Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNA.

Chiarella S, De Cola A, Scaglione GL, Carletti E, Graziano V, Barcaroli D, Lo Sterzo C, Di Matteo A, Di Ilio C, Falini B, Arcovito A, De Laurenzi V, Federici L.

Nucleic Acids Res. 2013 Mar 1;41(5):3228-39. doi: 10.1093/nar/gkt001. Epub 2013 Jan 16.


Intrinsically disordered regions of nucleophosmin/B23 regulate its RNA binding activity through their inter- and intra-molecular association.

Hisaoka M, Nagata K, Okuwaki M.

Nucleic Acids Res. 2014 Jan;42(2):1180-95. doi: 10.1093/nar/gkt897. Epub 2013 Oct 7.


Novel interaction of the Z-DNA binding domain of human ADAR1 with the oncogenic c-Myc promoter G-quadruplex.

Kang HJ, Le TV, Kim K, Hur J, Kim KK, Park HJ.

J Mol Biol. 2014 Jul 15;426(14):2594-604. doi: 10.1016/j.jmb.2014.05.001. Epub 2014 May 9.


Nucleophosmin mutations in acute myeloid leukemia: a tale of protein unfolding and mislocalization.

Federici L, Falini B.

Protein Sci. 2013 May;22(5):545-56. doi: 10.1002/pro.2240. Epub 2013 Mar 18. Review.


Role of mutual interactions in the chemical and thermal stability of nucleophosmin NPM1 domains.

Marasco D, Ruggiero A, Vascotto C, Poletto M, Scognamiglio PL, Tell G, Vitagliano L.

Biochem Biophys Res Commun. 2013 Jan 11;430(2):523-8. doi: 10.1016/j.bbrc.2012.12.002. Epub 2012 Dec 8.


Erythroid differentiation-associated gene interacts with NPM1 (nucleophosmin/B23) and increases its protein stability, resisting cell apoptosis.

Zhang MJ, Ding YL, Xu CW, Yang Y, Lian WX, Zhan YQ, Li W, Xu WX, Yu M, Ge CH, Ning HM, Li CY, Yang XM.

FEBS J. 2012 Aug;279(16):2848-62. doi: 10.1111/j.1742-4658.2012.08663.x. Epub 2012 Jul 5.


The structure and functions of NPM1/Nucleophsmin/B23, a multifunctional nucleolar acidic protein.

Okuwaki M.

J Biochem. 2008 Apr;143(4):441-8. Epub 2007 Nov 16. Review.


Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions.

Di Natale C, Scognamiglio PL, Cascella R, Cecchi C, Russo A, Leone M, Penco A, Relini A, Federici L, Di Matteo A, Chiti F, Vitagliano L, Marasco D.

FASEB J. 2015 Sep;29(9):3689-701. doi: 10.1096/fj.14-269522. Epub 2015 May 14.


Recognition of intermolecular G-quadruplexes by full length nucleophosmin. Effect of a leukaemia-associated mutation.

Bañuelos S, Lectez B, Taneva SG, Ormaza G, Alonso-Mariño M, Calle X, Urbaneja MA.

FEBS Lett. 2013 Jul 11;587(14):2254-9. doi: 10.1016/j.febslet.2013.05.055. Epub 2013 Jun 4.


Ras-dependent recruitment of c-Myc for transcriptional activation of nucleophosmin/B23 in highly malignant U1 bladder cancer cells.

Yeh CW, Huang SS, Lee RP, Yung BY.

Mol Pharmacol. 2006 Oct;70(4):1443-53. Epub 2006 Jul 20.


Stabilization of G-quadruplex DNA with platinum(II) Schiff base complexes: luminescent probe and down-regulation of c-myc oncogene expression.

Wu P, Ma DL, Leung CH, Yan SC, Zhu N, Abagyan R, Che CM.

Chemistry. 2009 Dec 7;15(47):13008-21. doi: 10.1002/chem.200901943.


[Research on NPM1 gene mutations in acute myeloid leukemia].

Chen HY, Lu QY.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Feb;21(1):258-62. doi: 10.7534/j.issn.1009-2137.2013.01.053. Review. Chinese.


Structure-based design of platinum(II) complexes as c-myc oncogene down-regulators and luminescent probes for G-quadruplex DNA.

Wang P, Leung CH, Ma DL, Yan SC, Che CM.

Chemistry. 2010 Jun 18;16(23):6900-11. doi: 10.1002/chem.201000167.


High-affinity homologous peptide nucleic acid probes for targeting a quadruplex-forming sequence from a MYC promoter element.

Roy S, Tanious FA, Wilson WD, Ly DH, Armitage BA.

Biochemistry. 2007 Sep 18;46(37):10433-43. Epub 2007 Aug 24.


Mutated regions of nucleophosmin 1 elicit both CD4(+) and CD8(+) T-cell responses in patients with acute myeloid leukemia.

Greiner J, Ono Y, Hofmann S, Schmitt A, Mehring E, Götz M, Guillaume P, Döhner K, Mytilineos J, Döhner H, Schmitt M.

Blood. 2012 Aug 9;120(6):1282-9. doi: 10.1182/blood-2011-11-394395. Epub 2012 May 16.

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