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Is SIRT2 required for necroptosis?

Newton K, Hildebrand JM, Shen Z, Rodriguez D, Alvarez-Diaz S, Petersen S, Shah S, Dugger DL, Huang C, Auwerx J, Vandenabeele P, Green DR, Ashkenazi A, Dixit VM, Kaiser WJ, Strasser A, Degterev A, Silke J.

Nature. 2014 Feb 27;506(7489):E4-6. doi: 10.1038/nature13024.


The NAD-dependent deacetylase SIRT2 is required for programmed necrosis.

Narayan N, Lee IH, Borenstein R, Sun J, Wong R, Tong G, Fergusson MM, Liu J, Rovira II, Cheng HL, Wang G, Gucek M, Lombard D, Alt FW, Sack MN, Murphy E, Cao L, Finkel T.

Nature. 2012 Dec 13;492(7428):199-204. doi: 10.1038/nature11700. Epub 2012 Nov 28. Retraction in: Nature. 2014 Feb 27;506(7489):516.


Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner.

Preyat N, Rossi M, Kers J, Chen L, Bertin J, Gough PJ, Le Moine A, Rongvaux A, Van Gool F, Leo O.

Cell Death Differ. 2016 Jan;23(1):29-40. doi: 10.1038/cdd.2015.60. Epub 2015 May 22.


SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.

Lo Sasso G, Menzies KJ, Mottis A, Piersigilli A, Perino A, Yamamoto H, Schoonjans K, Auwerx J.

PLoS One. 2014 Jul 29;9(7):e103573. doi: 10.1371/journal.pone.0103573. eCollection 2014.


Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells.

Li Y, Nie H, Wu D, Zhang J, Wei X, Ying W.

Neurosci Lett. 2013 Jun 7;544:36-40. doi: 10.1016/j.neulet.2013.03.032. Epub 2013 Apr 6.


SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia.

Chen H, Wu D, Ding X, Ying W.

Neuroreport. 2015 Jan 21;26(2):88-93. doi: 10.1097/WNR.0000000000000305.


Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis.

Petrilli A, Bott M, Fernández-Valle C.

Oncotarget. 2013 Dec;4(12):2354-65.


The QKI-PLP pathway controls SIRT2 abundance in CNS myelin.

Zhu H, Zhao L, Wang E, Dimova N, Liu G, Feng Y, Cambi F.

Glia. 2012 Jan;60(1):69-82. doi: 10.1002/glia.21248. Epub 2011 Sep 21.


High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects.

Yu J, Wu Y, Yang P.

J Neurochem. 2016 May;137(3):371-83. doi: 10.1111/jnc.13587. Epub 2016 Mar 17.


SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation.

Seo KS, Park JH, Heo JY, Jing K, Han J, Min KN, Kim C, Koh GY, Lim K, Kang GY, Uee Lee J, Yim YH, Shong M, Kwak TH, Kweon GR.

Oncogene. 2015 Mar 12;34(11):1354-62. doi: 10.1038/onc.2014.76. Epub 2014 Mar 31.


Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase.

Nagai T, Ikeda M, Chiba S, Kanno S, Mizuno K.

J Cell Sci. 2013 Oct 1;126(Pt 19):4369-80. doi: 10.1242/jcs.127209. Epub 2013 Jul 25.


Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels.

Shimizu K, Quillinan N, Orfila JE, Herson PS.

Exp Neurol. 2016 Jan;275 Pt 1:78-83. doi: 10.1016/j.expneurol.2015.10.014. Epub 2015 Oct 30.


SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth.

Ma L, Maruwge W, Strambi A, D'Arcy P, Pellegrini P, Kis L, de Milito A, Lain S, Brodin B.

Cell Death Dis. 2014 Oct 23;5:e1483. doi: 10.1038/cddis.2014.385.


SIRT2 interacts with β-catenin to inhibit Wnt signaling output in response to radiation-induced stress.

Nguyen P, Lee S, Lorang-Leins D, Trepel J, Smart DK.

Mol Cancer Res. 2014 Sep;12(9):1244-53. doi: 10.1158/1541-7786.MCR-14-0223-T. Epub 2014 May 27.


Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.

Singh S, Kumar PU, Thakur S, Kiran S, Sen B, Sharma S, Rao VV, Poongothai AR, Ramakrishna G.

Tumour Biol. 2015 Aug;36(8):6159-71. doi: 10.1007/s13277-015-3300-y. Epub 2015 Mar 21.


PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages.

Kim MJ, Kim DW, Park JH, Kim SJ, Lee CH, Yong JI, Ryu EJ, Cho SB, Yeo HJ, Hyeon J, Cho SW, Kim DS, Son O, Park J, Han KH, Cho YS, Eum WS, Choi SY.

Free Radic Biol Med. 2013 Oct;63:432-45. doi: 10.1016/j.freeradbiomed.2013.06.005. Epub 2013 Jun 12.


SIRT2 negatively regulates insulin resistance in C2C12 skeletal muscle cells.

Arora A, Dey CS.

Biochim Biophys Acta. 2014 Sep;1842(9):1372-8. doi: 10.1016/j.bbadis.2014.04.027. Epub 2014 May 2.


Sirt2 suppresses glioma cell growth through targeting NF-κB-miR-21 axis.

Li Y, Dai D, Lu Q, Fei M, Li M, Wu X.

Biochem Biophys Res Commun. 2013 Nov 22;441(3):661-7. doi: 10.1016/j.bbrc.2013.10.077. Epub 2013 Oct 22.


Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin.

Ramakrishnan G, Davaakhuu G, Kaplun L, Chung WC, Rana A, Atfi A, Miele L, Tzivion G.

J Biol Chem. 2014 Feb 28;289(9):6054-66. doi: 10.1074/jbc.M113.537266. Epub 2014 Jan 20.


Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation.

Ji S, Doucette JR, Nazarali AJ.

J Mol Cell Biol. 2011 Dec;3(6):351-9. doi: 10.1093/jmcb/mjr009. Epub 2011 Jun 13.

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