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Fangchinoline inhibits cell proliferation via Akt/GSK-3beta/ cyclin D1 signaling and induces apoptosis in MDA-MB-231 breast cancer cells.

Wang CD, Yuan CF, Bu YQ, Wu XM, Wan JY, Zhang L, Hu N, Liu XJ, Zu Y, Liu GL, Song FZ.

Asian Pac J Cancer Prev. 2014;15(2):769-73.


Luteolin induces G1 arrest in human nasopharyngeal carcinoma cells via the Akt-GSK-3β-Cyclin D1 pathway.

Ong CS, Zhou J, Ong CN, Shen HM.

Cancer Lett. 2010 Dec 8;298(2):167-75. doi: 10.1016/j.canlet.2010.07.001. Epub 2010 Jul 23.


Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.

Wang Y, Lam JB, Lam KS, Liu J, Lam MC, Hoo RL, Wu D, Cooper GJ, Xu A.

Cancer Res. 2006 Dec 1;66(23):11462-70.


2,3,7,8-Tetrachlorodibenzo-p-dioxin stimulates proliferation of HAPI microglia by affecting the Akt/GSK-3β/cyclin D1 signaling pathway.

Xu G, Li Y, Yoshimoto K, Wu Q, Chen G, Iwata T, Mizusawa N, Wan C, Nie X.

Toxicol Lett. 2014 Jan 30;224(3):362-70. doi: 10.1016/j.toxlet.2013.11.003. Epub 2013 Nov 11.


Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17β-estradiol.

Ye X, Yuan L, Zhang L, Zhao J, Zhang CM, Deng HY.

Asian Pac J Cancer Prev. 2014;15(12):5001-7.


Molecular targeting of Akt by thymoquinone promotes G(1) arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells.

Rajput S, Kumar BN, Dey KK, Pal I, Parekh A, Mandal M.

Life Sci. 2013 Nov 13;93(21):783-90. doi: 10.1016/j.lfs.2013.09.009. Epub 2013 Sep 15.


Reg4-induced mitogenesis involves Akt-GSK3β-β-Catenin-TCF-4 signaling in human colorectal cancer.

Bishnupuri KS, Sainathan SK, Bishnupuri K, Leahy DR, Luo Q, Anant S, Houchen CW, Dieckgraefe BK.

Mol Carcinog. 2014 Feb;53 Suppl 1:E169-80. doi: 10.1002/mc.22088. Epub 2013 Oct 22.


The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells.

Li JP, Yang YX, Liu QL, Pan ST, He ZX, Zhang X, Yang T, Chen XW, Wang D, Qiu JX, Zhou SF.

Drug Des Devel Ther. 2015 Mar 16;9:1627-52. doi: 10.2147/DDDT.S75378. eCollection 2015.


Embelin-Induced Apoptosis of Human Prostate Cancer Cells Is Mediated through Modulation of Akt and β-Catenin Signaling.

Park N, Baek HS, Chun YJ.

PLoS One. 2015 Aug 7;10(8):e0134760. doi: 10.1371/journal.pone.0134760. eCollection 2015.


Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via β-catenin/GSK-3β modulation in colorectal carcinoma.

Lee YK, Lin TH, Chang CF, Lo YL.

PLoS One. 2013 Nov 26;8(11):e82478. doi: 10.1371/journal.pone.0082478. eCollection 2013. Erratum in: PLoS One. 2014;9(9):e107784.


Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action.

Wang S, Liu Q, Zhang Y, Liu K, Yu P, Liu K, Luan J, Duan H, Lu Z, Wang F, Wu E, Yagasaki K, Zhang G.

Mol Cancer. 2009 Oct 1;8:81. doi: 10.1186/1476-4598-8-81.


Brazilein, a compound isolated from Caesalpinia sappan Linn., induced growth inhibition in breast cancer cells via involvement of GSK-3β/β-Catenin/cyclin D1 pathway.

Tao LY, Li JY, Zhang JY.

Chem Biol Interact. 2013 Oct 25;206(1):1-5. doi: 10.1016/j.cbi.2013.07.015. Epub 2013 Aug 13.


RNA silencing of integrin-linked kinase increases the sensitivity of the A549 lung cancer cell line to cisplatin and promotes its apoptosis.

Zhao X, Xu Z, Wang Z, Wu Z, Gong Y, Zhou L, Xiang Y.

Mol Med Rep. 2015 Jul;12(1):960-6. doi: 10.3892/mmr.2015.3471. Epub 2015 Mar 11.


Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer.

Srirangam A, Mitra R, Wang M, Gorski JC, Badve S, Baldridge L, Hamilton J, Kishimoto H, Hawes J, Li L, Orschell CM, Srour EF, Blum JS, Donner D, Sledge GW, Nakshatri H, Potter DA.

Clin Cancer Res. 2006 Mar 15;12(6):1883-96.


Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo.

Chen J, Zeng J, Xin M, Huang W, Chen X.

Horm Metab Res. 2011 Sep;43(10):681-6. doi: 10.1055/s-0031-1286306. Epub 2011 Sep 19.


Molecular mechanism underlying the anticancer effect of simvastatin on MDA-MB-231 human breast cancer cells.

Shen YY, Yuan Y, Du YY, Pan YY.

Mol Med Rep. 2015 Jul;12(1):623-30. doi: 10.3892/mmr.2015.3411. Epub 2015 Mar 4.


Opposite regulation by PI3K/Akt and MAPK/ERK pathways of tissue factor expression, cell-associated procoagulant activity and invasiveness in MDA-MB-231 cells.

Hu C, Huang L, Gest C, Xi X, Janin A, Soria C, Li H, Lu H.

J Hematol Oncol. 2012 Jul 11;5:16. doi: 10.1186/1756-8722-5-16.

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