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Items: 1 to 20 of 108

1.

Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.

Acharya S, Safaie BM, Wongkongkathep P, Ivanova MI, Attar A, Klärner FG, Schrader T, Loo JA, Bitan G, Lapidus LJ.

J Biol Chem. 2014 Apr 11;289(15):10727-37. doi: 10.1074/jbc.M113.524520. Epub 2014 Feb 24.

2.

Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins.

Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, Schrader T, Wang C, Bitan G.

J Am Chem Soc. 2011 Oct 26;133(42):16958-69. doi: 10.1021/ja206279b. Epub 2011 Sep 29.

3.

Aggregation of α-synuclein is kinetically controlled by intramolecular diffusion.

Ahmad B, Chen Y, Lapidus LJ.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2336-41. doi: 10.1073/pnas.1109526109. Epub 2012 Jan 27.

4.
5.

The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity.

Herzog G, Shmueli MD, Levy L, Engel L, Gazit E, Klärner FG, Schrader T, Bitan G, Segal D.

Biochemistry. 2015 Jun 23;54(24):3729-38. doi: 10.1021/bi501092p. Epub 2015 Jun 11.

6.

Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01.

Sinha S, Du Z, Maiti P, Klärner FG, Schrader T, Wang C, Bitan G.

ACS Chem Neurosci. 2012 Jun 20;3(6):451-8. doi: 10.1021/cn200133x. Epub 2012 Mar 7.

7.

Site-specific interactions of Cu(II) with alpha and beta-synuclein: bridging the molecular gap between metal binding and aggregation.

Binolfi A, Lamberto GR, Duran R, Quintanar L, Bertoncini CW, Souza JM, Cerveñansky C, Zweckstetter M, Griesinger C, Fernández CO.

J Am Chem Soc. 2008 Sep 3;130(35):11801-12. doi: 10.1021/ja803494v. Epub 2008 Aug 9.

PMID:
18693689
8.

Investigation of intramolecular dynamics and conformations of α-, β- and γ-synuclein.

Ducas VC, Rhoades E.

PLoS One. 2014 Jan 28;9(1):e86983. doi: 10.1371/journal.pone.0086983. eCollection 2014.

9.

Effects of Mutations on the Reconfiguration Rate of α-Synuclein.

Acharya S, Saha S, Ahmad B, Lapidus LJ.

J Phys Chem B. 2015 Dec 17;119(50):15443-50. doi: 10.1021/acs.jpcb.5b10136. Epub 2015 Dec 4.

10.

Curcumin prevents aggregation in α-synuclein by increasing reconfiguration rate.

Ahmad B, Lapidus LJ.

J Biol Chem. 2012 Mar 16;287(12):9193-9. doi: 10.1074/jbc.M111.325548. Epub 2012 Jan 20.

11.

The early events of alpha-synuclein oligomerization revealed by photo-induced cross-linking.

Li HT, Lin XJ, Xie YY, Hu HY.

Protein Pept Lett. 2006;13(4):385-90.

PMID:
16712515
12.

Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state.

Högen T, Levin J, Schmidt F, Caruana M, Vassallo N, Kretzschmar H, Bötzel K, Kamp F, Giese A.

Biophys J. 2012 Apr 4;102(7):1646-55. doi: 10.1016/j.bpj.2012.01.059. Epub 2012 Apr 3.

13.

Copper(II)-induced self-oligomerization of alpha-synuclein.

Paik SR, Shin HJ, Lee JH, Chang CS, Kim J.

Biochem J. 1999 Jun 15;340 ( Pt 3):821-8.

14.

The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.

Porcari R, Proukakis C, Waudby CA, Bolognesi B, Mangione PP, Paton JF, Mullin S, Cabrita LD, Penco A, Relini A, Verona G, Vendruscolo M, Stoppini M, Tartaglia GG, Camilloni C, Christodoulou J, Schapira AH, Bellotti V.

J Biol Chem. 2015 Jan 23;290(4):2395-404. doi: 10.1074/jbc.M114.610527. Epub 2014 Dec 10.

15.

A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein.

Allison JR, Rivers RC, Christodoulou JC, Vendruscolo M, Dobson CM.

Biochemistry. 2014 Nov 25;53(46):7170-83. doi: 10.1021/bi5009326. Epub 2014 Nov 12.

16.

Covalent α-synuclein dimers: chemico-physical and aggregation properties.

Pivato M, De Franceschi G, Tosatto L, Frare E, Kumar D, Aioanei D, Brucale M, Tessari I, Bisaglia M, Samori B, de Laureto PP, Bubacco L.

PLoS One. 2012;7(12):e50027. doi: 10.1371/journal.pone.0050027. Epub 2012 Dec 13.

17.

Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to α-synuclein aggregates.

Deeg AA, Reiner AM, Schmidt F, Schueder F, Ryazanov S, Ruf VC, Giller K, Becker S, Leonov A, Griesinger C, Giese A, Zinth W.

Biochim Biophys Acta. 2015 Sep;1850(9):1884-90. doi: 10.1016/j.bbagen.2015.05.021. Epub 2015 May 29.

PMID:
26028294
18.

NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.

Fernández CO, Hoyer W, Zweckstetter M, Jares-Erijman EA, Subramaniam V, Griesinger C, Jovin TM.

EMBO J. 2004 May 19;23(10):2039-46. Epub 2004 Apr 22.

19.

Molecular tweezers inhibit islet amyloid polypeptide assembly and toxicity by a new mechanism.

Lopes DH, Attar A, Nair G, Hayden EY, Du Z, McDaniel K, Dutt S, Bravo-Rodriguez K, Mittal S, Klärner FG, Wang C, Sanchez-Garcia E, Schrader T, Bitan G.

ACS Chem Biol. 2015 Jun 19;10(6):1555-69. doi: 10.1021/acschembio.5b00146. Epub 2015 Apr 16.

20.

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

Prabhudesai S, Sinha S, Attar A, Kotagiri A, Fitzmaurice AG, Lakshmanan R, Ivanova MI, Loo JA, Klärner FG, Schrader T, Stahl M, Bitan G, Bronstein JM.

Neurotherapeutics. 2012 Apr;9(2):464-76. doi: 10.1007/s13311-012-0105-1. Erratum in: Neurotherapeutics. 2012 Apr;9(2):486. Lakshmanan, Ravi [corrected to Lakshmanan, Rajeswari].

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