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PP2 prevents β-adrenergic stimulation of cardiac pacemaker activity.

Huang J, Lin YC, Hileman S, Martin KH, Hull R, Yu HG.

J Cardiovasc Pharmacol. 2014 Jun;63(6):533-43. doi: 10.1097/FJC.0000000000000078.


PP2 prevents isoproterenol stimulation of cardiac pacemaker activity.

Huang J, Lin YC, Hileman S, Martin KH, Hull R, Yu HG.

J Cardiovasc Pharmacol. 2015 Feb;65(2):193-202. doi: 10.1097/FJC.0000000000000078. Erratum in: J Cardiovasc Pharmacol. 2015 Apr;65(4):398. J Cardiovasc Pharmacol. 2015 Feb;65(2):192.


Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531.

Li CH, Zhang Q, Teng B, Mustafa SJ, Huang JY, Yu HG.

Am J Physiol Cell Physiol. 2008 Jan;294(1):C355-62. Epub 2007 Oct 31.


Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial node.

Liao Z, Lockhead D, Larson ED, Proenza C.

J Gen Physiol. 2010 Sep;136(3):247-58. doi: 10.1085/jgp.201010488. Epub 2010 Aug 16.


Adrenergic regulation of HCN4 channel requires protein association with β2-adrenergic receptor.

Greene D, Kang S, Kosenko A, Hoshi N.

J Biol Chem. 2012 Jul 6;287(28):23690-7. doi: 10.1074/jbc.M112.366955. Epub 2012 May 21.


Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker.

Saito Y, Nakamura K, Yoshida M, Sugiyama H, Ohe T, Kurokawa J, Furukawa T, Takano M, Nagase S, Morita H, Kusano KF, Ito H.

PLoS One. 2015 Sep 18;10(9):e0138193. doi: 10.1371/journal.pone.0138193. eCollection 2015.


Pacemaker activity of the human sinoatrial node: effects of HCN4 mutations on the hyperpolarization-activated current.

Verkerk AO, Wilders R.

Europace. 2014 Mar;16(3):384-95. doi: 10.1093/europace/eut348. Review.


Ca2+-activated adenylyl cyclase 1 introduces Ca2+-dependence to beta-adrenergic stimulation of HCN2 current.

Kryukova YN, Protas L, Robinson RB.

J Mol Cell Cardiol. 2012 Jun;52(6):1233-9. doi: 10.1016/j.yjmcc.2012.03.010. Epub 2012 Mar 29.


The role of the funny current in pacemaker activity.

DiFrancesco D.

Circ Res. 2010 Feb 19;106(3):434-46. doi: 10.1161/CIRCRESAHA.109.208041. Review.


The funny current: cellular basis for the control of heart rate.

DiFrancesco D, Borer JS.

Drugs. 2007;67 Suppl 2:15-24. Review.


Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase/Src and mTOR pathways.

Marin TM, Clemente CF, Santos AM, Picardi PK, Pascoal VD, Lopes-Cendes I, Saad MJ, Franchini KG.

Circ Res. 2008 Oct 10;103(8):813-24. doi: 10.1161/CIRCRESAHA.108.179754. Epub 2008 Aug 28.


Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4.

Baruscotti M, Bucchi A, Viscomi C, Mandelli G, Consalez G, Gnecchi-Rusconi T, Montano N, Casali KR, Micheloni S, Barbuti A, DiFrancesco D.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1705-10. doi: 10.1073/pnas.1010122108. Epub 2011 Jan 10.


Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.

Lolicato M, Bucchi A, Arrigoni C, Zucca S, Nardini M, Schroeder I, Simmons K, Aquila M, DiFrancesco D, Bolognesi M, Schwede F, Kashin D, Fishwick CW, Johnson AP, Thiel G, Moroni A.

Nat Chem Biol. 2014 Jun;10(6):457-62. doi: 10.1038/nchembio.1521. Epub 2014 Apr 28. Erratum in: Nat Chem Biol. 2014 Aug;10(8):692.


The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart.

Stieber J, Herrmann S, Feil S, Löster J, Feil R, Biel M, Hofmann F, Ludwig A.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15235-40. Epub 2003 Dec 1.


Rescue of a trafficking defective human pacemaker channel via a novel mechanism: roles of Src, Fyn, and Yes tyrosine kinases.

Lin YC, Huang J, Kan H, Frisbee JC, Yu HG.

J Biol Chem. 2009 Oct 30;284(44):30433-40. doi: 10.1074/jbc.M109.039180. Epub 2009 Sep 11.


Isoproterenol induces actin depolymerization in human airway smooth muscle cells via activation of an Src kinase and GS.

Hirshman CA, Zhu D, Pertel T, Panettieri RA, Emala CW.

Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L924-31.


Physiology and pharmacology of the cardiac pacemaker ("funny") current.

Baruscotti M, Bucchi A, Difrancesco D.

Pharmacol Ther. 2005 Jul;107(1):59-79. Review.


Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node.

Altomare C, Terragni B, Brioschi C, Milanesi R, Pagliuca C, Viscomi C, Moroni A, Baruscotti M, DiFrancesco D.

J Physiol. 2003 Jun 1;549(Pt 2):347-59. Epub 2003 Apr 17.

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