Format
Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 193

1.

Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants.

Hwang HS, Nitu FR, Yang Y, Walweel K, Pereira L, Johnson CN, Faggioni M, Chazin WJ, Laver D, George AL Jr, Cornea RL, Bers DM, Knollmann BC.

Circ Res. 2014 Mar 28;114(7):1114-24. doi: 10.1161/CIRCRESAHA.114.303391. Epub 2014 Feb 21.

2.

Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease.

Vassilakopoulou V, Calver BL, Thanassoulas A, Beck K, Hu H, Buntwal L, Smith A, Theodoridou M, Kashir J, Blayney L, Livaniou E, Nounesis G, Lai FA, Nomikos M.

Biochim Biophys Acta. 2015 Nov;1850(11):2168-76. doi: 10.1016/j.bbagen.2015.07.001. Epub 2015 Jul 9.

PMID:
26164367
3.

Arrhythmogenic calmodulin mutations disrupt intracellular cardiomyocyte Ca2+ regulation by distinct mechanisms.

Yin G, Hassan F, Haroun AR, Murphy LL, Crotti L, Schwartz PJ, George AL, Satin J.

J Am Heart Assoc. 2014 Jun 23;3(3):e000996. doi: 10.1161/JAHA.114.000996.

4.

Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+ Release.

Søndergaard MT, Tian X, Liu Y, Wang R, Chazin WJ, Chen SR, Overgaard MT.

J Biol Chem. 2015 Oct 23;290(43):26151-62. doi: 10.1074/jbc.M115.676627. Epub 2015 Aug 26.

PMID:
26309258
5.

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.

Gomez-Hurtado N, Boczek NJ, Kryshtal DO, Johnson CN, Sun J, Nitu FR, Cornea RL, Chazin WJ, Calvert ML, Tester DJ, Ackerman MJ, Knollmann BC.

Circ Arrhythm Electrophysiol. 2016 Aug;9(8). pii: e004161. doi: 10.1161/CIRCEP.116.004161.

PMID:
27516456
6.

Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.

Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M.

Biochem Biophys Res Commun. 2010 Apr 9;394(3):660-6. doi: 10.1016/j.bbrc.2010.03.046. Epub 2010 Mar 10.

7.

Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes.

Fukuda M, Yamamoto T, Nishimura S, Kato T, Murakami W, Hino A, Ono M, Tateishi H, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M.

Biochem Biophys Res Commun. 2014 May 23;448(1):1-7. doi: 10.1016/j.bbrc.2014.03.152. Epub 2014 Apr 19.

PMID:
24755079
8.

Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass.

Hilliard FA, Steele DS, Laver D, Yang Z, Le Marchand SJ, Chopra N, Piston DW, Huke S, Knollmann BC.

J Mol Cell Cardiol. 2010 Feb;48(2):293-301. doi: 10.1016/j.yjmcc.2009.10.005. Epub 2009 Oct 14.

9.

Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure.

Yang Y, Guo T, Oda T, Chakraborty A, Chen L, Uchinoumi H, Knowlton AA, Fruen BR, Cornea RL, Meissner G, Bers DM.

Circ Res. 2014 Jan 17;114(2):295-306. doi: 10.1161/CIRCRESAHA.114.302857. Epub 2013 Nov 1.

10.
11.

Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.

Sedej S, Heinzel FR, Walther S, Dybkova N, Wakula P, Groborz J, Gronau P, Maier LS, Vos MA, Lai FA, Napolitano C, Priori SG, Kockskämper J, Pieske B.

Cardiovasc Res. 2010 Jul 1;87(1):50-9. doi: 10.1093/cvr/cvq007. Epub 2010 Jan 15.

12.

Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function.

Zhao YT, Valdivia CR, Gurrola GB, Powers PP, Willis BC, Moss RL, Jalife J, Valdivia HH.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1669-77. doi: 10.1073/pnas.1419795112. Epub 2015 Mar 16.

13.

Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia.

Liu N, Ruan Y, Denegri M, Bachetti T, Li Y, Colombi B, Napolitano C, Coetzee WA, Priori SG.

J Mol Cell Cardiol. 2011 Jan;50(1):214-22. doi: 10.1016/j.yjmcc.2010.10.001. Epub 2010 Oct 23.

PMID:
20937285
14.

Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.

Hwang HS, Hasdemir C, Laver D, Mehra D, Turhan K, Faggioni M, Yin H, Knollmann BC.

Circ Arrhythm Electrophysiol. 2011 Apr;4(2):128-35. doi: 10.1161/CIRCEP.110.959916. Epub 2011 Jan 26.

15.

Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.

Uchinoumi H, Yano M, Suetomi T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.

Circ Res. 2010 Apr 30;106(8):1413-24. doi: 10.1161/CIRCRESAHA.109.209312. Epub 2010 Mar 11.

16.

Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia.

Shan J, Xie W, Betzenhauser M, Reiken S, Chen BX, Wronska A, Marks AR.

Circ Res. 2012 Aug 31;111(6):708-17. doi: 10.1161/CIRCRESAHA.112.273342. Epub 2012 Jul 24.

17.

Mechanism of calsequestrin regulation of single cardiac ryanodine receptor in normal and pathological conditions.

Chen H, Valle G, Furlan S, Nani A, Gyorke S, Fill M, Volpe P.

J Gen Physiol. 2013 Aug;142(2):127-36. doi: 10.1085/jgp.201311022. Epub 2013 Jul 15.

18.

Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca(2+) currents and promote proarrhythmic behavior in ventricular myocytes.

Limpitikul WB, Dick IE, Joshi-Mukherjee R, Overgaard MT, George AL Jr, Yue DT.

J Mol Cell Cardiol. 2014 Sep;74:115-24. doi: 10.1016/j.yjmcc.2014.04.022. Epub 2014 May 8.

19.

Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts.

Hino A, Yano M, Kato T, Fukuda M, Suetomi T, Ono M, Murakami W, Susa T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.

Cardiovasc Res. 2012 Dec 1;96(3):433-43. doi: 10.1093/cvr/cvs271. Epub 2012 Aug 14.

20.

Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor.

Arnáiz-Cot JJ, Damon BJ, Zhang XH, Cleemann L, Yamaguchi N, Meissner G, Morad M.

J Physiol. 2013 Sep 1;591(17):4287-99. doi: 10.1113/jphysiol.2013.256123. Epub 2013 Jul 8.

Items per page

Supplemental Content

Write to the Help Desk