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Items: 1 to 20 of 121

1.

Effectiveness of a substituted β-cyclodextrin to prevent cyclosarin toxicity in vivo.

Worek F, Seeger T, Zengerle M, Kubik S, Thiermann H, Wille T.

Toxicol Lett. 2014 Apr 21;226(2):222-7. doi: 10.1016/j.toxlet.2014.02.010. Epub 2014 Feb 20.

PMID:
24561299
2.

Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro.

Worek F, Seeger T, Goldsmith M, Ashani Y, Leader H, Sussman JS, Tawfik D, Thiermann H, Wille T.

Arch Toxicol. 2014 Jun;88(6):1257-66. doi: 10.1007/s00204-014-1204-z. Epub 2014 Jan 30.

PMID:
24477626
3.

Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: a proof-of-concept study.

Worek F, Seeger T, Reiter G, Goldsmith M, Ashani Y, Leader H, Sussman JL, Aggarwal N, Thiermann H, Tawfik DS.

Toxicol Lett. 2014 Nov 18;231(1):45-54. doi: 10.1016/j.toxlet.2014.09.003. Epub 2014 Sep 6.

PMID:
25195526
4.

Elimination pathways of cyclosarin (GF) mediated by β-cyclodextrin in vitro: pharmacokinetic and toxicokinetic aspects.

Kranawetvogl A, Schüler J, Müller S, Thiermann H, Worek F, Reiter G.

Toxicol Lett. 2013 Oct 24;222(2):164-70. doi: 10.1016/j.toxlet.2013.07.017. Epub 2013 Jul 29.

PMID:
23906718
5.

Elimination kinetics and molecular reaction mechanisms of cyclosarin (GF) by an oxime substituted β-cyclodextrin derivative in vitro.

Kranawetvogl A, Müller S, Kubik S, Spruit H, Thiermann H, Worek F, Noort D, Reiter G.

Toxicol Lett. 2015 Nov 19;239(1):41-52. doi: 10.1016/j.toxlet.2015.08.007. Epub 2015 Aug 10.

PMID:
26272752
6.

Detoxification of nerve agents by a substituted beta-cyclodextrin: application of a modified biological assay.

Wille T, Tenberken O, Reiter G, Müller S, Le Provost R, Lafont O, Estour F, Thiermann H, Worek F.

Toxicology. 2009 Nov 30;265(3):96-100. doi: 10.1016/j.tox.2009.09.018. Epub 2009 Oct 1.

PMID:
19800384
7.

Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach.

Worek F, Wille T, Aurbek N, Eyer P, Thiermann H.

Toxicol Appl Pharmacol. 2010 Dec 15;249(3):231-7. doi: 10.1016/j.taap.2010.09.021. Epub 2010 Oct 1.

PMID:
20888357
8.

Evaluation of nine oximes on in vivo reactivation of blood, brain, and tissue cholinesterase activity inhibited by organophosphorus nerve agents at lethal dose.

Shih TM, Skovira JW, O'Donnell JC, McDonough JH.

Toxicol Mech Methods. 2009 Sep;19(6-7):386-400. doi: 10.1080/15376510903213892.

PMID:
19778239
9.

Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.

Albuquerque EX, Pereira EF, Aracava Y, Fawcett WP, Oliveira M, Randall WR, Hamilton TA, Kan RK, Romano JA Jr, Adler M.

Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13220-5. Epub 2006 Aug 16.

10.

Detoxification of alkyl methylphosphonofluoridates by an oxime-substituted β-cyclodextrin--an in vitro structure-activity study.

Bierwisch A, Zengerle M, Thiermann H, Kubik S, Worek F.

Toxicol Lett. 2014 Jan 13;224(2):209-14. doi: 10.1016/j.toxlet.2013.10.024. Epub 2013 Oct 31.

PMID:
24185128
11.

In vivo acetylcholinesterase reactivation in male guinea pigs and rhesus macaques following cyclosarin exposure and treatment with 1,1'-methylenebis{4-[(hydroxyimino)methyl] pyridinium} dimethanesulfonate.

Harvilchuck JA, Hong SP, Richey JS, Osheroff MR, Johnson JD.

Int J Toxicol. 2013 Jul-Aug;32(4 Suppl):99S-107S. doi: 10.1177/1091581813498778.

PMID:
23929454
12.

In vivo reactivation by oximes of inhibited blood, brain and peripheral tissue cholinesterase activity following exposure to nerve agents in guinea pigs.

Shih TM, Skovira JW, O'Donnell JC, McDonough JH.

Chem Biol Interact. 2010 Sep 6;187(1-3):207-14. doi: 10.1016/j.cbi.2010.03.006. Epub 2010 Mar 9.

PMID:
20223229
13.

Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.

Aurbek N, Thiermann H, Eyer F, Eyer P, Worek F.

Toxicology. 2009 May 17;259(3):133-9. doi: 10.1016/j.tox.2009.02.014. Epub 2009 Mar 6.

PMID:
19428953
14.

Bioscavengers for the protection of humans against organophosphate toxicity.

Doctor BP, Saxena A.

Chem Biol Interact. 2005 Dec 15;157-158:167-71. Epub 2005 Nov 15.

PMID:
16293236
15.

Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase.

Aurbek N, Thiermann H, Szinicz L, Eyer P, Worek F.

Toxicology. 2006 Jul 5;224(1-2):91-9. Epub 2006 Apr 27.

PMID:
16720069
16.

New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin.

Hrabinova M, Musilek K, Jun D, Kuca K.

J Enzyme Inhib Med Chem. 2006 Oct;21(5):515-9.

PMID:
17194020
17.

Reactivation of brain acetylcholinesterase by monoisonitrosoacetone increases the therapeutic efficacy against nerve agents in guinea pigs.

Skovira JW, O'Donnell JC, Koplovitz I, Kan RK, McDonough JH, Shih TM.

Chem Biol Interact. 2010 Sep 6;187(1-3):318-24. doi: 10.1016/j.cbi.2010.03.010. Epub 2010 Mar 15.

PMID:
20230808
18.

New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: evaluation of the detoxification using a half-quantitative enzymatic assay.

Kalakuntla RK, Wille T, Le Provost R, Letort S, Reiter G, Müller S, Thiermann H, Worek F, Gouhier G, Lafont O, Estour F.

Toxicol Lett. 2013 Feb 4;216(2-3):200-5. doi: 10.1016/j.toxlet.2012.11.020. Epub 2012 Nov 29.

PMID:
23201439
19.

Progress in the development of enzyme-based nerve agent bioscavengers.

Nachon F, Brazzolotto X, Trovaslet M, Masson P.

Chem Biol Interact. 2013 Dec 5;206(3):536-44. doi: 10.1016/j.cbi.2013.06.012. Epub 2013 Jun 26. Review.

PMID:
23811386
20.

Signs of cyclosarin-induced neurotoxicity and its pharmacological treatment with quaternary pyridinium-oximes reactivators.

Krejcova-Kunesova G, Bartosova L, Kuca K.

Toxicology. 2005 Dec;216(1):32-40. Epub 2005 Aug 26.

PMID:
16126317

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